Canonical and non-canonical TGF-B signaling (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none SMAD4PSMAD3PSMAD2NucleusTrabecular meshwork cellBMPR2BMPR1PMAPK14LOXL4LOXL2LOXL1LOXBMP1GREM1LOXL4LOXL2LOXLOXL1LOXLOXL1PJNK2PJNK1LOXLOXL1TGFBR2TGFBR1LOXL1LOXL4LOXL1LOXL4TGFB1Name: Canonical and non-canonical TGF-B signalingOrganism: Homo sapiens


Description

This pathway is modeled after Figure 9 in the article "Gremlin utilizes canonical and non-canonical TGFB signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells". Gremlin is enables the TGF-B signaling pathways to oversee LOX and LOXL proteins and also demonstrates that the non-canonical JNK1/2 complex, canonical SMAD, and P38 signaling pathways are involved in this pathway. TGF-B signaling is possible through Gremlin's ability to bock the BMP signaling pathway which inhibits TGF-B receptors. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3874)

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Quality Tags

Image:PLoS_OpenAccess.pngOpen Access
Image:Curated.pngApproved version

Ontology Terms

Bibliography

  1. Sethi A, Wordinger RJ, Clark AF; ''Gremlin utilizes canonical and non-canonical TGFβ signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells.''; Exp Eye Res, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137224
Approved
view10:05, 1 March 2025EgonwModified description
134950view02:05, 30 July 2024EweitzRefine layout
134949view02:04, 30 July 2024EweitzEconomize layout
134948view01:41, 30 July 2024EweitzRefine state layering
134947view01:40, 30 July 2024EweitzMitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
134946view01:39, 30 July 2024EweitzMitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
134945view01:38, 30 July 2024EweitzMitigate graphical discrepancy between PathVisio and Kaavio / Pvjs
134944view01:37, 30 July 2024EweitzRefine position of cell type label, state indicators
134943view01:36, 30 July 2024EweitzIncrease font size
134942view01:34, 30 July 2024EweitzUse gene symbols, economize layout
134941view01:30, 30 July 2024EweitzRestore state position
134940view01:29, 30 July 2024EweitzEconomize layout
134939view01:27, 30 July 2024EweitzEconomize layout
128070view00:30, 24 January 2024EweitzStandardize case
128069view00:29, 24 January 2024EweitzOntology Term : 'trabecular meshwork cell' added !
116461view10:05, 7 May 2021EweitzModified title
106348view21:35, 21 August 2019KhanspersModified description
105549view06:10, 9 August 2019KhanspersModified description
89272view23:31, 28 August 2016Khanspersadded states, labels, interactions
89112view18:48, 22 August 2016AAR&CoModified description
89061view06:44, 19 August 2016FehrhartMinor cosmetic changes
88954view21:13, 17 August 2016AAR&CoOntology Term : 'Bone morphogenetic proteins signaling pathway' added !
88953view21:11, 17 August 2016AAR&CoOntology Term : 'primary angle-closure glaucoma' added !
88802view21:30, 14 August 2016AAR&CoModified description
88801view21:13, 14 August 2016AAR&CoLiterature Reference Added
88800view21:10, 14 August 2016AAR&CoNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
BMP1GeneProductENSG00000168487 (Ensembl) BMP
BMPR1GeneProductENSG00000107779 (Ensembl)
BMPR2GeneProductENSG00000204217 (Ensembl)
GREM1GeneProductENSG00000166923 (Ensembl) Grem
JNK1GeneProductENSG00000107643 (Ensembl)
JNK2GeneProductENSG00000050748 (Ensembl)
LOXGeneProductENSG00000113083 (Ensembl)
LOXL1GeneProductENSG00000129038 (Ensembl)
LOXL2GeneProductENSG00000134013 (Ensembl)
LOXL4GeneProductENSG00000138131 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl) P38
SMAD2GeneProductENSG00000175387 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl) TGF-Beta
TGFBR1GeneProductENSG00000106799 (Ensembl)
TGFBR2GeneProductENSG00000163513 (Ensembl)

Annotated Interactions

No annotated interactions

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