ATR signaling (Homo sapiens)

From WikiPathways

Jump to: navigation, search
ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none ATRIPDNARPA2RPA3RPA12. 9-1-1 & TOPBP1 recruitment and ATR activationOrigin firing3. Substrate phosphorylation1. ATR+ATRIP recruitmentReplisome stabilityCell arrest cycle9-1-1 complexRAD9BPRAD1RAD9AHUS1PPCHEK1ATRATRIPDNAATRATRIPRPA2RPA3RPA1DNAPATRTOPBP19-1-1 complexHUS1RAD9BRAD9ARAD1RPA2RPA3RPA1Name: ATR signalingOrganism: Homo sapiens


Description

This pathway is modeled after Figure 1 in the article " ATR signalling: more than meeting at the fork" (See Bibliography). This pathway details the ATR signaling which commences when there is a gap in the single strand DNA. It details the usage of several independent checkpoint proteins which then cause TOPBP1 dependent activation of the phosphorylation and kinase of a large number of substrates including CHK1 to commence regulation of cellular response to DNA damage and replication stress. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3875)

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Image:PLoS_OpenAccess.pngOpen Access
Image:Curated.pngApproved version
Image:Wplogo_31.pngCommunity: CPTAC

Ontology Terms

Bibliography

  1. Nam EA, Cortez D; ''ATR signalling: more than meeting at the fork.''; Biochem J, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137225
Approved
view10:05, 1 March 2025EgonwModified description
128592view23:42, 14 February 2024EweitzUse straight lines to avoid site-PathVisio graphics bug
128591view23:41, 14 February 2024EweitzTweak placements for earlier fidelity, economy
128590view23:40, 14 February 2024EweitzUse complex graphics for 9-1-1 complex
128589view23:37, 14 February 2024EweitzFix phosphorylation site placements
128588view23:36, 14 February 2024EweitzEconomize layout
128587view23:31, 14 February 2024EweitzRefine arrow curvature, economize layout
128586view23:30, 14 February 2024EweitzStandardize case
127928view19:47, 17 January 2024Khanspersupdated xrefs for RPAs
117657
CPTAC
view11:52, 22 May 2021EweitzModified title
105872view04:48, 16 August 2019KhanspersModified description
105433view04:33, 8 August 2019KhanspersModified description
103010view15:20, 31 January 2019Mkutmonupdated outdated Ensembl identifier (ATRIP)
102151view19:01, 4 December 2018Khanspersupdated identifier for ATRIP
90121view04:33, 14 October 2016Khanspersupdated unconnected
89275view06:40, 29 August 2016Khansperslayout change etc
88959view21:29, 17 August 2016AAR&CoReduced White Space
88958view21:28, 17 August 2016AAR&CoAdded Steps of Complex Formation
88957view21:26, 17 August 2016AAR&CoPeriodical save, work in progress
88817view22:49, 14 August 2016AAR&CoOntology Term : 'DNA damage response pathway' added !
88816view22:48, 14 August 2016AAR&CoOntology Term : 'DNA replication pathway' added !
88815view22:48, 14 August 2016AAR&CoModified description
88808view22:29, 14 August 2016AAR&CoNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ATRGeneProductENSG00000175054 (Ensembl)
ATRIPGeneProductENSG00000164053 (Ensembl)
CHEK1GeneProductENSG00000149554 (Ensembl)
HUS1GeneProductENSG00000136273 (Ensembl)
RAD1GeneProductENSG00000113456 (Ensembl)
RAD9AGeneProductENSG00000172613 (Ensembl)
RAD9BGeneProductENSG00000151164 (Ensembl)
RPA1GeneProductRPA1 (HGNC)
RPA2GeneProductRPA2 (HGNC)
RPA3GeneProductRPA3 (HGNC)
TOPBP1GeneProductENSG00000163781 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3875"
Personal tools