Benzene metabolism (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none NonenzymaticrearrangementCYP2E1CYP2E11,2-BenzoquinoneNQO1DihydrodioldehydrogenasePhenolCatecholBenzeneMicrosomal Epoxide HydrolaseBenzene diol epoxideS-Phenylmercapturic acidBenzene dihydrodiolMPOOxepineGlutathione S-transferasep-benzoquinoneHydroquinoneBenzene oxideNQO1MPOName: Benzene metabolismOrganism: Homo sapiens


Description

This pathway describes the metabolism of benzene. It is metabolised in the liver and forms several metabolites that can be toxic to the human body. Some of the metabolites are very volatile and can be found in blood and exhaled breath.

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Quality Tags

Image:Curated.pngApproved version
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Bibliography

  1. Rappaport SM, Kim S, Lan Q, Vermeulen R, Waidyanatha S, Zhang L, Li G, Yin S, Hayes RB, Rothman N, Smith MT; ''Evidence that humans metabolize benzene via two pathways.''; Environ Health Perspect, 2009 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
106161
Approved
view12:05, 16 August 2019MaintBotHMDB identifier normalization
97681view13:56, 1 June 2018AMTanOntology Term : 'hepatocyte' added !
94538view07:01, 21 September 2017EgonwRemoved a redundant newline.
89359view13:30, 7 September 2016Riannefijtenadded identifier vor microsomal epoxide hydrolase
89346view09:52, 6 September 2016RiannefijtenModified description
89345view09:52, 6 September 2016RiannefijtenModified description
89344view04:35, 6 September 2016EgonwUsed mim-conversion and annotated the catalysis with a mim approach too.
89339view03:16, 5 September 2016EgonwOntology Term : 'classic metabolic pathway' added !
89338view03:16, 5 September 2016EgonwOntology Term : 'phase I biotransformation pathway via cytochrome P450' added !
89313view13:15, 1 September 2016RiannefijtenNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
1,2-BenzoquinoneMetaboliteHMDB0012133 (HMDB)
Benzene dihydrodiolMetabolite418 (PubChem-compound)
Benzene diol epoxideMetabolite
Benzene oxideMetabolite104944 (PubChem-compound)
BenzeneMetaboliteHMDB0001505 (HMDB)
CYP2E1GeneProductENSG00000130649 (Ensembl)
CatecholMetabolite289 (PubChem-compound)
Dihydrodiol dehydrogenaseProtein27294 (Entrez Gene)
Glutathione S-transferaseGeneProduct2944 (Entrez Gene)
HydroquinoneMetaboliteHMDB0002434 (HMDB)
MPOGeneProduct4353 (Entrez Gene)
Microsomal Epoxide HydrolaseGeneProduct2052 (Entrez Gene)
NQO1GeneProductENSG00000181019 (Ensembl)
OxepineMetabolite6451477 (PubChem-compound)
PhenolMetaboliteHMDB0000228 (HMDB)
S-Phenylmercapturic acidMetaboliteHMDB0042011 (HMDB)
p-benzoquinoneMetabolite4650 (PubChem-compound)

Annotated Interactions

No annotated interactions

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