Leptin-insulin signaling overlap (Homo sapiens)
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DNA
PI3K
IRS
IRS
IRS
PIK3CG
STAT3
STAT3
Irs3
INSR
LEP
JAK2
SOCS3
IRS4
JAK2
SOCS2
PIK3R3
DGKZ
PIP2
LEPR
INS
IRS1
PDPK1
AKT1
IRS2
SOCS1
PIK3CG
STAT3
JAK2
PIP3
Description
Overlap of cellular insulin and leptin signaling. Proteins on this pathway have targeted assays available via the
CPTAC Assay Portal
Comments
HomologyMapper
This pathway was inferred from Mus musculus pathway "Leptin Insulin Overlap", WP578 revision, with a 95.0% conversion rate.
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Bibliography
Banks AS, Davis SM, Bates SH, Myers MG Jr; ''Activation of downstream signals by the long form of the leptin receptor.''; J Biol Chem, 2000
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
118425
view
14:24, 27 May 2021
Mkutmon
removed unused reference
116797
view
10:02, 14 May 2021
Eweitz
Modified title
107152
view
14:23, 17 September 2019
MaintBot
ChEBI identifier normalization
106627
view
20:53, 12 September 2019
Khanspers
Modified description
105633
view
05:04, 10 August 2019
Khanspers
Modified description
90771
view
01:19, 14 December 2016
Khanspers
Ontology Term : 'leptin system pathway' added !
90770
view
01:18, 14 December 2016
Khanspers
Ontology Term : 'insulin signaling pathway' added !
90769
view
01:18, 14 December 2016
Khanspers
New pathway
External references
DataNodes
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Name
Type
Database reference
Comment
AKT1
GeneProduct
ENSG00000142208 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11651
DGKZ
GeneProduct
ENSG00000149091 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000040479
INS
GeneProduct
ENSG00000254647 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16333
INSR
GeneProduct
ENSG00000171105 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16337
IRS1
GeneProduct
ENSG00000169047 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16367
IRS2
GeneProduct
ENSG00000185950 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:384783
IRS4
GeneProduct
ENSG00000133124 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16370
Irs3
GeneProduct
No homologues found for original id L:16369
JAK2
GeneProduct
ENSG00000096968 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16452
LEP
GeneProduct
ENSG00000174697 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P41160
LEPR
GeneProduct
ENSG00000116678 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16847
PDPK1
GeneProduct
ENSG00000140992 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18607
PIK3CG
GeneProduct
ENSG00000105851 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020573
PIK3R3
GeneProduct
ENSG00000117461 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028698
PIP2
Metabolite
CHEBI:18348 (ChEBI)
PIP3
Metabolite
CHEBI:16618 (ChEBI)
SOCS1
GeneProduct
ENSG00000185338 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12703
SOCS2
GeneProduct
ENSG00000120833 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:216233
SOCS3
GeneProduct
ENSG00000184557 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12702
STAT3
GeneProduct
ENSG00000168610 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20848
Annotated Interactions
No annotated interactions
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