Oxidative damage response (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Adaptive response in liverMuscle contractionChemotaxisPhagocyte recruitmentInflammation, etc.Nf-kB pathwayROSComplement activationC3aGSHInduction of antioxidant genesC3-convertaseCell lysis and clearanceC3bMembrane lysis complexC4b/2aInhibitor of cell deathC5aROSCell survivalC4aStressLiver regenerationLegendMitochondrial pathwayActivator of cell death(classical pathway)C3b/4b, C3b, C3dProteasomeFormation of apoptotic bodiesPCNATNFRSF1BC5BCL2Oxidative stressBADMAP3K9CDC42TDP2TNK2DNA replicationMAP2K4BAG4NFKB1TNFGADD45AMAP3K1TRAF6CASP3ApoptosisBAK1CDKN1CCDKN1ACDKN1BMAPK13NFKBIEMAPK10C4BC2C1QCC1QBC1SC1RC1QATRAF3TRAF2TRAF1CR2CyctCYCSC5AR1C3AR1APAF1CASP9Name: Oxidative damage responseLicense: CC0Organism: Homo sapiens


Description

This pathway shows how tissue is damaged when oxygen levels are not balanced and become too high.


Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3941).

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway "Oxidative Damage", WP1496 revision 90169, with a 97.0% conversion rate.

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Quality Tags

Image:Curated.pngApproved version
Image:NeedsRef.pngAdd references
Image:MissingXref.pngAnnotate nodes
Homology Converted

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
137953
Approved
view20:52, 10 March 2025KhanspersModified description
128368view23:29, 2 February 2024EweitzUpgrade legend
128367view23:04, 2 February 2024EweitzLicense is CC0
128366view23:03, 2 February 2024EweitzEnlarge tiny text, economize layout, standardize case
123242view18:42, 6 July 2022EgonwMade three pathways clickable
117040view14:12, 16 May 2021EweitzModified title
106568view21:15, 6 September 2019KhanspersModified description
105771view19:39, 15 August 2019KhanspersModified description
94696view23:22, 4 October 2017KhanspersModified description
94695view23:22, 4 October 2017Khanspersremoved GenMAPP notes
90810view18:32, 14 December 2016KhanspersOntology Term : 'oxidative stress response pathway' added !
90809view18:30, 14 December 2016KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
APAF1GeneProductENSG00000120868 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11783
ApoptosisPathwayWP1254 (WikiPathways)
BADGeneProductENSG00000002330 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12015
BAG4GeneProductENSG00000156735 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67384
BAK1GeneProductENSG00000030110 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12018
BCL2GeneProductENSG00000171791 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12043
C1QAGeneProductENSG00000173372 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12259
C1QBGeneProductENSG00000173369 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12260
C1QCGeneProductENSG00000159189 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12262
C1RGeneProductENSG00000159403 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50909
C1SGeneProductENSG00000182326 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:50908
C2GeneProductENSG00000166278 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12263
C3AR1GeneProductENSG00000171860 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12267
C4BGeneProductENSG00000224389 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12268
C5AR1GeneProductENSG00000197405 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12273
C5GeneProductENSG00000106804 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15139
CASP3GeneProductENSG00000164305 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12367
CASP9GeneProductENSG00000132906 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12371
CDC42GeneProductENSG00000070831 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12540
CDKN1AGeneProductENSG00000124762 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12575
CDKN1BGeneProductENSG00000111276 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12576
CDKN1CGeneProductENSG00000129757 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12577
CR2GeneProductENSG00000117322 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12902
CYCSGeneProductENSG00000172115 (Ensembl)
  • Rel,Nup93,Nrf1,Them2,Syap1,Zfp259,2700059L22Rik,,Cotl1
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13063
CyctGeneProductNo homologues found for original id L:13067
DNA replicationPathwayWP150 (WikiPathways)
GADD45AGeneProductENSG00000116717 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13197
MAP2K4GeneProductENSG00000065559 (Ensembl)
  • Xbp1,Mapk10,Klhl8,Mapk10
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26398
MAP3K1GeneProductENSG00000095015 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26401
MAP3K9GeneProductENSG00000006432 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:338372
MAPK10GeneProductENSG00000109339 (Ensembl)
  • Map2k4,Nlk,Fos,Fzd7,Jund1,ORF19,Map2k4,Dhodh,Map3k7,Dvl3,Eda,Rac1,Jup,Mllt4,Mink1,Myef2,Dusp10,Rala,Etv6,Frk,Wee1,Rexo1
  • Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26414
MAPK13GeneProductENSG00000156711 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26415
NFKB1GeneProductENSG00000109320 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18033
NFKBIEGeneProductENSG00000146232 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18037
Oxidative stressPathwayWP412 (WikiPathways)
PCNAGeneProductENSG00000132646 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18538
TDP2GeneProductENSG00000111802 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:56196
TNFGeneProductENSG00000232810 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21926
TNFRSF1BGeneProductENSG00000028137 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21938
TNK2GeneProductENSG00000061938 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:51789
TRAF1GeneProductENSG00000056558 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22029
TRAF2GeneProductENSG00000127191 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22030
TRAF3GeneProductENSG00000131323 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22031
TRAF6GeneProductENSG00000175104 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22034

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3941"
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