TYROBP causal network in microglia (Homo sapiens)
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LGALS9C
ITGAM
SAMSN1
IL13RA1
GPX1
TYROBP
DPYD
GIMAP2
CXCL16
TCIRG1
BIN2
CD4
FKBP15
NCKAP1L
SLC7A7
ABCC4
PPP1R18
HLX
PYCARD
NPC2
SLC1A5
IGSF6
RBM47
APBB1IP
C1QC
ITGB2
ADAP2
TMEM106A
CAPG
STAT5A
ELF4
RPS6KA1
SPP1
CREB3L2
ZFP36L2
RUNX3
PLEK
NRROS
LYL1
LOXL3
C3
NCF2
GAPT
CD37
TGFBR1
GAL3ST4
CD84
ITGAX
RNASE6
HCLS1
IL10RA
SH2B3
CYTL1
TNFRSF1B
RGS1
IL18
KCNE3
SFT2D2
MAF
LHFPL2
Description
The direct and indirect causal inputs upstream and downstream of Tyrobp in microglial cells.
Proteins on this pathway have targeted assays available via the
CPTAC Assay Portal
Comments
HomologyMapper
This pathway was inferred from Mus musculus pathway "TYROBP Causal Network", WP3625 revision 85694 with a 96.0% conversion rate.
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Bibliography
Zhang B, Gaiteri C, Bodea LG, Wang Z, McElwee J, Podtelezhnikov AA, Zhang C, Xie T, Tran L, Dobrin R, Fluder E, Clurman B, Melquist S, Narayanan M, Suver C, Shah H, Mahajan M, Gillis T, Mysore J, MacDonald ME, Lamb JR, Bennett DA, Molony C, Stone DJ, Gudnason V, Myers AJ, Schadt EE, Neumann H, Zhu J, Emilsson V; ''Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease.''; Cell, 2013
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
116679
view
13:21, 9 May 2021
Eweitz
Modified title
116678
view
12:59, 9 May 2021
Eweitz
Modified title
107558
view
00:00, 20 October 2019
AlexanderPico
Modified description
105838
view
23:10, 15 August 2019
Khanspers
Modified description
98920
view
23:35, 15 October 2018
AlexanderPico
Modified description
98918
view
23:25, 15 October 2018
AlexanderPico
Modified description
90843
view
19:39, 14 December 2016
Khanspers
Ontology Term : 'microglial cell' added !
90842
view
19:39, 14 December 2016
Khanspers
Ontology Term : 'innate immune response pathway' added !
90839
view
19:38, 14 December 2016
Khanspers
Ontology Term : 'Alzheimer disease pathway' added !
90838
view
19:33, 14 December 2016
Khanspers
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ABCC4
GeneProduct
ENSG00000125257 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032849
ADAP2
GeneProduct
ENSG00000184060 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020709
APBB1IP
GeneProduct
ENSG00000077420 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026786
BIN2
GeneProduct
ENSG00000110934 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000098112
C1QC
GeneProduct
ENSG00000159189 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036896
C3
GeneProduct
ENSG00000125730 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024164
CAPG
GeneProduct
ENSG00000042493 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000056737
CD37
GeneProduct
ENSG00000104894 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030798
CD4
GeneProduct
ENSG00000010610 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000023274
CD84
GeneProduct
ENSG00000066294 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000038147
CREB3L2
GeneProduct
ENSG00000182158 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000038648
CXCL16
GeneProduct
ENSG00000161921 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018920
CYTL1
GeneProduct
ENSG00000170891 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000062329
DPYD
GeneProduct
ENSG00000188641 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033308
ELF4
GeneProduct
ENSG00000102034 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031103
FKBP15
GeneProduct
ENSG00000119321 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000066151
GAL3ST4
GeneProduct
ENSG00000197093 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000075593
GAPT
GeneProduct
ENSG00000175857 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000046006
GIMAP2
GeneProduct
ENSG00000106560 (Ensembl)
GPX1
GeneProduct
ENSG00000233276 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000063856
HCLS1
GeneProduct
ENSG00000180353 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022831
HLX
GeneProduct
ENSG00000136630 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039377
IGSF6
GeneProduct
ENSG00000140749 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000035004
IL10RA
GeneProduct
ENSG00000110324 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032089
IL13RA1
GeneProduct
ENSG00000131724 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000017057
IL18
GeneProduct
ENSG00000150782 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039217
ITGAM
GeneProduct
ENSG00000169896 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030786
ITGAX
GeneProduct
ENSG00000140678 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030789
ITGB2
GeneProduct
ENSG00000160255 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000000290
KCNE3
GeneProduct
ENSG00000175538 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000035165
LGALS9C
GeneProduct
ENSG00000171916 (Ensembl)
LHFPL2
GeneProduct
ENSG00000145685 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000045312
LOXL3
GeneProduct
ENSG00000115318 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000000693
LYL1
GeneProduct
ENSG00000104903 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034041
MAF
GeneProduct
ENSG00000178573 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000055435
NCF2
GeneProduct
ENSG00000116701 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026480
NCKAP1L
GeneProduct
ENSG00000123338 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022488
NPC2
GeneProduct
ENSG00000119655 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021242
NRROS
GeneProduct
ENSG00000174004 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000052384
PLEK
GeneProduct
ENSG00000115956 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020120
PPP1R18
GeneProduct
ENSG00000146112 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034595
PYCARD
GeneProduct
ENSG00000103490 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030793
RBM47
GeneProduct
ENSG00000163694 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000070780
RGS1
GeneProduct
ENSG00000090104 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026358
RNASE6
GeneProduct
ENSG00000169413 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021880
RPS6KA1
GeneProduct
ENSG00000117676 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000003644
RUNX3
GeneProduct
ENSG00000020633 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000070691
SAMSN1
GeneProduct
ENSG00000155307 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022876
SFT2D2
GeneProduct
ENSG00000213064 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000040848
SH2B3
GeneProduct
ENSG00000111252 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000042594
SLC1A5
GeneProduct
ENSG00000105281 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000001918
SLC7A7
GeneProduct
ENSG00000155465 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000000958
SPP1
GeneProduct
ENSG00000118785 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000029304
STAT5A
GeneProduct
ENSG00000126561 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000004043
TCIRG1
GeneProduct
ENSG00000110719 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000001750
TGFBR1
GeneProduct
ENSG00000106799 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000007613
TMEM106A
GeneProduct
ENSG00000184988 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034947
TNFRSF1B
GeneProduct
ENSG00000028137 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028599
TYROBP
GeneProduct
ENSG00000011600 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030579
ZFP36L2
GeneProduct
ENSG00000152518 (Ensembl)
Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000045817
Annotated Interactions
No annotated interactions
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View approved pathways at the new wikipathways.org.Quality Tags
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DataNodes
Annotated Interactions
No annotated interactions