GPR40 pathway (Homo sapiens)
From WikiPathways
Description
Binding of free fatty acids to GPR40 initiates a downstream signaling cascade which involves activation of a transducer protein “guanine nucleotide-binding protein subunit alpha-11� (GNA11). Next phospholipase c (PLC) hormone is activated which hydrolyzes membrane phospholipids (such as phosphatidylinositol-4-5-biphosphate) into second messenger molecules inositol-1-4-5-trophosphate (IP3) and Diacylglycerol (DAG). IP3 initiates calcium efflux from endoplasmic reticulum and increase intracellular calcium concentration. Increased intracellular calcium concentration is involved in activating the insulin exocytosis machinery. DAG on the other hand activates PKD1. PKD1 initiates F-actin remodeling and supports second phase of insulin exocytosis.
Quality Tags
Ontology Terms
Bibliography
- Poitout V, Lin DC; ''Modulating GPR40: therapeutic promise and potential in diabetes''; , 2013 PubMed Europe PMC Scholia
- Mancini AD, Poitout V; ''The fatty acid receptor FFA1/GPR40 a decade later: how much do we know? Mancini AD1, Poitout V.''; , 2013 PubMed Europe PMC Scholia
History
View all... |
External references
DataNodes
View all... |
Name | Type | Database reference | Comment |
---|---|---|---|
Ca2+ | Metabolite | CHEBI:29108 (ChEBI) | |
DAG | Metabolite | CHEBI:18035 (ChEBI) | |
GNA11 | GeneProduct | ENSG00000088256 (Ensembl) | |
GPR40 | GeneProduct | ENSG00000126266 (Ensembl) | |
IP3R | GeneProduct | ENSG00000096433 (Ensembl) | |
PKD1 | GeneProduct | ENSG00000008710 (Ensembl) | |
PLCB1 | GeneProduct | ENSG00000182621 (Ensembl) | |
PLCB2 | GeneProduct | ENSG00000137841 (Ensembl) | |
PLCB3 | GeneProduct | ENSG00000149782 (Ensembl) | |
PLCD1 | GeneProduct | ENSG00000187091 (Ensembl) | |
PLCD3 | GeneProduct | ENSG00000161714 (Ensembl) | |
PLCE1 | GeneProduct | ENSG00000138193 (Ensembl) | |
PLCG1 | GeneProduct | ENSG00000124181 (Ensembl) | |
PLCG2 | GeneProduct | ENSG00000197943 (Ensembl) | |
PLCH1 | GeneProduct | ENSG00000114805 (Ensembl) | |
PLCL1 | GeneProduct | ENSG00000115896 (Ensembl) | |
PLCZ1 | GeneProduct | ENSG00000139151 (Ensembl) | |
Unknown target genes | GeneProduct | ||
inositol-3-phosphate | Metabolite | CHEBI:16595 (ChEBI) |
Annotated Interactions
No annotated interactions