H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity (Homo sapiens)
From WikiPathways
Description
In this proposed model, H19 interacts with macroH2A, and this may consequently lead to de-repression of genes including CDK8, CDK4, and CCND1. Increased CDK4-cyclin D1 complex phosphorylates Rb to disrupt Rb-E2F1 interaction, leading to E2F1 activation. The increase of CDK8 expression enhances the function of mediator complex including MED1, and facilitates the gene regulation by β-catenin. These downstream targets could work in a synergistic way of promoting cell proliferation and increasing cell motility in CRC.
Reference: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5264449/
Proteins on this pathway have targeted assays available via the CPTAC Assay PortalQuality Tags
Ontology Terms
Saving...Bibliography
- Ohtsuka M, Ling H, Ivan C, Pichler M, Matsushita D, Goblirsch M, Stiegelbauer V, Shigeyasu K, Zhang X, Chen M, Vidhu F, Bartholomeusz GA, Toiyama Y, Kusunoki M, Doki Y, Mori M, Song S, Gunther JR, Krishnan S, Slaby O, Goel A, Ajani JA, Radovich M, Calin GA; ''H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-β-Catenin Signaling in Colorectal Cancer.''; EBioMedicine, 2016 PubMed Europe PMC Scholia
History
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External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| CCND1 | GeneProduct | ENSG00000110092 (Ensembl)  | |
| CDH1 | GeneProduct | ENSG00000039068 (Ensembl) | |
| CDK4 | GeneProduct | ENSG00000135446 (Ensembl) | |
| CDK8 | GeneProduct | ENSG00000132964 (Ensembl) | |
| CSRP2 | GeneProduct | ENSG00000175183 (Ensembl) | |
| CTNNB1 | GeneProduct | ENSG00000168036 (Ensembl) | |
| E2F1 | GeneProduct | ENSG00000101412 (Ensembl) | |
| G1-S transition | Pathway | WP45 (WikiPathways) | |
| H19 | Rna | ENSG00000130600 (Ensembl) | |
| JAG1 | GeneProduct | ENSG00000101384 (Ensembl) | |
| MED1 | GeneProduct | ENSG00000125686 (Ensembl) | |
| PMAIP1 | GeneProduct | ENSG00000141682 (Ensembl) | |
| RB1 | GeneProduct | ENSG00000139687 (Ensembl) | |
| SOX4 | GeneProduct | ENSG00000124766 (Ensembl) | |
| TULP3 | GeneProduct | ENSG00000078246 (Ensembl) | |
| macroH2A | GeneProduct | ENSG00000113648 (Ensembl) |
Annotated Interactions
No annotated interactions
