PDGFR-beta pathway (Homo sapiens)

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1, 2NucleusPIK3CAPDGFRBPPLCG1PPRKCAERK1PGRB1PPJAK1PPRKCBPPPSTAT6JAK2PKRPSTAT3STAT1PPSTAT5AGRB2PHRASSOS1PSHC1PPRASA1MEKKPMEK1PSTAT5BPJNK1JNKK1RAF1PPELK1PSRFFOSPJUNPPPPCytoplasmExtracellular


Description

Simplified PDGFR-beta pathway, based on figure 7B from Zhang et al: https://www.ncbi.nlm.nih.gov/pubmed/27372738

Platelet-derived growth factor receptors (PDGFR) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer. There are two forms of the PDGFR, alpha and beta each encoded by a different gene. Depending on which growth factor is bound, PDGFR homo- or heterodimerizes. Source: Wikipedia

Protein phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.

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Bibliography

  1. Zhang H, Liu T, Zhang Z, Payne SH, Zhang B, McDermott JE, Zhou JY, Petyuk VA, Chen L, Ray D, Sun S, Yang F, Wang J, Shah P, Cha SW, Aiyetan P, Woo S, Tian Y, Gritsenko MA, Clauss TR, Choi C, Monroe ME, Thomas S, Nie S, Wu C, Moore RJ, Yu KH, Tabb DL, Fenyö D, Bafna V, Wang Y, Rodriguez H, Boja ES, Hiltke T, Rivers RC, Sokoll L, Zhu H, Shih IeM, Cope L, Pandey A, Snyder MP, Levine DA, Smith RD, Chan DW, Rodland KD; ''Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer.''; Cell, 2016 PubMed Europe PMC Scholia
  2. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
127259view00:53, 29 August 2023Khanspersadded RAF1 phospho sites
127258view00:39, 29 August 2023KhanspersAdded phospho sites
108157view10:41, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
108156view10:41, 29 November 2019FehrhartOntology Term : 'ovarian cancer' added !
105479view05:36, 8 August 2019KhanspersModified description
105437view04:49, 8 August 2019KhanspersModified description
92088view18:24, 25 April 2017AlexanderPicoModified description
91861view21:26, 31 March 2017KhanspersModified description
91860view21:13, 31 March 2017KhanspersOntology Term : 'ovarian cancer pathway' added !
91859view21:13, 31 March 2017KhanspersOntology Term : 'signaling pathway' added !
91852view21:02, 31 March 2017KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ELK1GeneProductENSG00000126767 (Ensembl)
ERK1GeneProductENSG00000102882 (Ensembl)
FOSGeneProductENSG00000170345 (Ensembl)
GRB1GeneProductENSG00000145675 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
JAK1GeneProductENSG00000162434 (Ensembl)
JAK2GeneProductENSG00000096968 (Ensembl)
JNK1GeneProductENSG00000107643 (Ensembl)
JNKK1GeneProductENSG00000065559 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
MEK1GeneProductENSG00000169032 (Ensembl)
MEKKGeneProductENSG00000095015 (Ensembl)
PDGFRBGeneProductENSG00000113721 (Ensembl)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PKRGeneProductENSG00000055332 (Ensembl)
PLCG1GeneProductENSG00000124181 (Ensembl)
PRKCAGeneProductENSG00000154229 (Ensembl)
PRKCBGeneProductENSG00000166501 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
RASA1GeneProductENSG00000145715 (Ensembl)
SHC1GeneProductENSG00000160691 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SRFGeneProductENSG00000112658 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
STAT5AGeneProductENSG00000126561 (Ensembl)
STAT5BGeneProductENSG00000173757 (Ensembl)
STAT6GeneProductENSG00000166888 (Ensembl)

Annotated Interactions

No annotated interactions

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