mir-193a and MVP in colon cancer metastasis (Mus musculus)

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Proposed model for the mechanism of colon cancer metastasis to the liver involves exporting miR-193a via exosomes sorted by major vault protein (MVP). In pre-metastatic cells miR-193a suppresses mouse colon cancer progression by directly targeting Caprin1, which is known to positively regulate the cell cycle and cell proliferation. Higher levels of miR-193a in tumor cells causes of cell cycle G1 arrest and cell proliferation repression through reduction of Caprin1 expression. In metatstatic cells, increased levels of MVP leads to MVP-mediated selective sorting of tumor suppressor miRNA into exosomes, which promotes tumor progression.