Intestinal infectious diseases (Homo sapiens)
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Description
Gastroenteritis, also known as infectious diarrhea, is an inflammatory disease of the stomach and small intestine caused by infections by viruses, bacteria, parasites and fungi. Signs and symptoms include diarrhea, vomiting, abdominal pain, fever, lack of energy, and dehydration. Gastroenteritis is usually an acute and self-limiting disease that does not require medication but the preferred method of treatment is oral rehydration therapy. Enterotoxigenic Escherichia coli (ETEC) is one of the leading bacterial causes of gastroenteritis worldwide (Kopic & Geibel 2010, Gonzales-Siles & Sjoling 2016).
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Na(+)/H(+) exchange regulatory cofactor NHE-RF4 (PDZD3, aka IKEPP, NHERF4) is a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. PDZD3 is expressed in the intestinal epithelium, where it preferentially accumulates at the apical surface, and there associates with the COOH terminus of GUCY2C (Scott et al. 2002).