Distal convoluted tubule 1 (DCT1) cell (Mus musculus)
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Description
The major function of the distal convoluted tubule 1 cell (DCT1 cell) in the kidney is to maintain proper iron, solute and water homeostasis. The cells are polarized and located in the nephron duct where they have unique transport functions which are maintained by specialized K(+), Na(+), and Cl(-) channels in the proximal or distal part of the cell.
Quality Tags
Ontology Terms
Saving...Bibliography
- Hamilton KL, Devor DC; ''Basolateral membrane K+ channels in renal epithelial cells.''; Am J Physiol Renal Physiol, 2012 PubMed Europe PMC Scholia
- Welling PA; ''Roles and Regulation of Renal K Channels.''; Annu Rev Physiol, 2016 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| CLC-K2 | Protein | Q9WUB6 (Uniprot-TrEMBL)  | |
| Cab39 | Protein | Q06138 (Uniprot-TrEMBL) | |
| Cl- | Metabolite | HMDB0000492 (HMDB) | |
| K+ | Metabolite | HMDB0000586 (HMDB) | |
| KS-WNK1 | Protein | P83741-7 (Uniprot-TrEMBL) | |
| NCC | Protein | P59158 (Uniprot-TrEMBL) | |
| Na+ | Metabolite | HMDB0000588 (HMDB) | |
| SPAK | Protein | Q9Z1W9 (Uniprot-TrEMBL) | |
| WNK1 | Protein | P83741 (Uniprot-TrEMBL) | |
| WNK4 | Protein | Q80UE6 (Uniprot-TrEMBL) | |
| kir4.1 | Protein | Q9jm63 (Uniprot-TrEMBL) | |
| kir5.1 | Protein | Q9Z307 (Uniprot-TrEMBL) |
Annotated Interactions
No annotated interactions
