Immune response to tuberculosis (Homo sapiens)

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1-4MX1IRF9IFITM1IFNGIRF9IRF1STAT1PIAS1PSMB8STAT1IFI35GIP2IFITM1SOCS1PSMB8JAK1IFI35TAP1IFIT3OAS1IFNGR1TYK2PTPN2IFIT1DRIP150IRF9STAT1STAT1STAT1STAT1STAT2STAT1STAT2GIP3JAK2PTPN2JAK1JAK2JAK1STAT1STAT2PTPN2IFNGR2IFNGR1IFNGR2IFNAR1IFNAR2IFNa/IFNb


Description

This pathway is published in "The human immune response to tuberculosis and its treatment: a view from the blood" (PMID: 25703554). Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bloom CI, Graham CM, Berry MP, Rozakeas F, Redford PS, Wang Y, Xu Z, Wilkinson KA, Wilkinson RJ, Kendrick Y, Devouassoux G, Ferry T, Miyara M, Bouvry D, Valeyre D, Gorochov G, Blankenship D, Saadatian M, Vanhems P, Beynon H, Vancheeswaran R, Wickremasinghe M, Chaussabel D, Banchereau J, Pascual V, Ho LP, Lipman M, O'Garra A; ''Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers.''; PLoS One, 2013 PubMed Europe PMC Scholia
  2. Berry MP, Graham CM, McNab FW, Xu Z, Bloch SA, Oni T, Wilkinson KA, Banchereau R, Skinner J, Wilkinson RJ, Quinn C, Blankenship D, Dhawan R, Cush JJ, Mejias A, Ramilo O, Kon OM, Pascual V, Banchereau J, Chaussabel D, O'Garra A; ''An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis.''; Nature, 2010 PubMed Europe PMC Scholia
  3. Cliff JM, Kaufmann SH, McShane H, van Helden P, O'Garra A; ''The human immune response to tuberculosis and its treatment: a view from the blood.''; Immunol Rev, 2015 PubMed Europe PMC Scholia
  4. Cliff JM, Lee JS, Constantinou N, Cho JE, Clark TG, Ronacher K, King EC, Lukey PT, Duncan K, Van Helden PD, Walzl G, Dockrell HM; ''Distinct phases of blood gene expression pattern through tuberculosis treatment reflect modulation of the humoral immune response.''; J Infect Dis, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129046view04:40, 9 March 2024EweitzOntology Term : 'immune response pathway' added !
120647view16:18, 22 December 2021EweitzRefine and tighten graphics
116566view10:49, 8 May 2021EweitzModified title
105840view23:11, 15 August 2019KhanspersModified description
101839view16:49, 12 November 2018EgonwReplaced an old Uniprot data source with the new one.
95608view12:10, 9 January 2018AndraModified description
95607view12:08, 9 January 2018AndraOntology Term : 'tuberculosis' added !
95606view12:07, 9 January 2018AndraAdded references
95605view11:57, 9 January 2018AndraInitial drawing of the pathway
95604view10:09, 9 January 2018AndraNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
DRIP150ComplexO60244 (Uniprot-TrEMBL)
GIP2GeneProduct
GIP3GeneProduct
IFI35GeneProductENSG00000068079 (Ensembl)
IFIT1GeneProductENSG00000185745 (Ensembl)
IFIT3GeneProductENSG00000119917 (Ensembl)
IFITM1GeneProductENSG00000185885 (Ensembl)
IFNAR1GeneProductENSG00000142166 (Ensembl)
IFNAR2GeneProductENSG00000159110 (Ensembl)
IFNGProtein
IFNGR1GeneProductENSG00000027697 (Ensembl)
IFNGR2GeneProductENSG00000159128 (Ensembl)
IFNa/IFNbProtein
IRF1GeneProductENSG00000125347 (Ensembl)
IRF9GeneProductENSG00000213928 (Ensembl)
JAK1GeneProductENSG00000162434 (Ensembl)
JAK2GeneProductENSG00000096968 (Ensembl)
MX1GeneProductENSG00000157601 (Ensembl)
OAS1GeneProductENSG00000089127 (Ensembl)
PIAS1GeneProductENSG00000033800 (Ensembl)
PSMB8GeneProductENSG00000204264 (Ensembl)
PTPN2GeneProductENSG00000175354 (Ensembl)
SOCS1GeneProductENSG00000185338 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT2GeneProductENSG00000170581 (Ensembl)
TAP1GeneProductENSG00000168394 (Ensembl)
TYK2GeneProductENSG00000105397 (Ensembl)

Annotated Interactions

No annotated interactions

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