Type 2 papillary renal cell carcinoma (Homo sapiens)

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Bibliography

1. Sudarshan S, Linehan WM, Neckers L; ''HIF and fumarate hydratase in renal cancer.''; Br J Cancer, 2007 PubMed Europe PMC Scholia
2. Skalsky YM, Ajuh PM, Parker C, Lamond AI, Goodwin G, Cooper CS; ''PRCC, the commonest TFE3 fusion partner in papillary renal carcinoma is associated with pre-mRNA splicing factors.''; Oncogene, 2001 PubMed Europe PMC Scholia
3. Linehan WM, Spellman PT, Ricketts CJ, Creighton CJ, Fei SS, Davis C, Wheeler DA, Murray BA, Schmidt L, Vocke CD, Peto M, Al Mamun AA, Shinbrot E, Sethi A, Brooks S, Rathmell WK, Brooks AN, Hoadley KA, Robertson AG, Brooks D, Bowlby R, Sadeghi S, Shen H, Weisenberger DJ, Bootwalla M, Baylin SB, Laird PW, Cherniack AD, Saksena G, Haake S, Li J, Liang H, Lu Y, Mills GB, Akbani R, Leiserson MD, Raphael BJ, Anur P, Bottaro D, Albiges L, Barnabas N, Choueiri TK, Czerniak B, Godwin AK, Hakimi AA, Ho TH, Hsieh J, Ittmann M, Kim WY, Krishnan B, Merino MJ, Mills Shaw KR, Reuter VE, Reznik E, Shelley CS, Shuch B, Signoretti S, Srinivasan R, Tamboli P, Thomas G, Tickoo S, Burnett K, Crain D, Gardner J, Lau K, Mallery D, Morris S, Paulauskis JD, Penny RJ, Shelton C, Shelton WT, Sherman M, Thompson E, Yena P, Avedon MT, Bowen J, Gastier-Foster JM, Gerken M, Leraas KM, Lichtenberg TM, Ramirez NC, Santos T, Wise L, Zmuda E, Demchok JA, Felau I, Hutter CM, Sheth M, Sofia HJ, Tarnuzzer R, Wang Z, Yang L, Zenklusen JC, Zhang J, Ayala B, Baboud J, Chudamani S, Liu J, Lolla L, Naresh R, Pihl T, Sun Q, Wan Y, Wu Y, Ally A, Balasundaram M, Balu S, Beroukhim R, Bodenheimer T, Buhay C, Butterfield YS, Carlsen R, Carter SL, Chao H, Chuah E, Clarke A, Covington KR, Dahdouli M, Dewal N, Dhalla N, Doddapaneni HV, Drummond JA, Gabriel SB, Gibbs RA, Guin R, Hale W, Hawes A, Hayes DN, Holt RA, Hoyle AP, Jefferys SR, Jones SJ, Jones CD, Kalra D, Kovar C, Lewis L, Ma Y, Marra MA, Mayo M, Meng S, Meyerson M, Mieczkowski PA, Moore RA, Morton D, Mose LE, Mungall AJ, Muzny D, Parker JS, Perou CM, Roach J, Schein JE, Schumacher SE, Shi Y, Simons JV, Sipahimalani P, Skelly T, Soloway MG, Sougnez C, Tam A, Tan D, Thiessen N, Veluvolu U, Wang M, Wilkerson MD, Wong T, Wu J, Xi L, Zhou J, Bedford J, Chen F, Fu Y, Gerstein M, Haussler D, Kasaian K, Lai P, Ling S, Radenbaugh A, Van Den Berg D, Weinstein JN, Zhu J, Albert M, Alexopoulou I, Andersen JJ, Auman JT, Bartlett J, Bastacky S, Bergsten J, Blute ML, Boice L, Bollag RJ, Boyd J, Castle E, Chen YB, Cheville JC, Curley E, Davies B, DeVolk A, Dhir R, Dike L, Eckman J, Engel J, Harr J, Hrebinko R, Huang M, Huelsenbeck-Dill L, Iacocca M, Jacobs B, Lobis M, Maranchie JK, McMeekin S, Myers J, Nelson J, Parfitt J, Parwani A, Petrelli N, Rabeno B, Roy S, Salner AL, Slaton J, Stanton M, Thompson RH, Thorne L, Tucker K, Weinberger PM, Winemiller C, Zach LA, Zuna R; ''Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.''; N Engl J Med, 2016 PubMed Europe PMC Scholia
4. Medendorp K, van Groningen JJ, Vreede L, Hetterschijt L, Brugmans L, van den Hurk WH, van Kessel AG; ''The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay.''; Exp Cell Res, 2009 PubMed Europe PMC Scholia
5. Kauffman EC, Ricketts CJ, Rais-Bahrami S, Yang Y, Merino MJ, Bottaro DP, Srinivasan R, Linehan WM; ''Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers.''; Nat Rev Urol, 2014 PubMed Europe PMC Scholia

History

External references

DataNodes

Name	Type	Database reference	Comment
ARNT2	GeneProduct	ENSG00000172379 (Ensembl)
ARNT	GeneProduct	ENSG00000143437 (Ensembl)
BIRC7	GeneProduct	ENSG00000101197 (Ensembl)
CADM2	GeneProduct	ENSG00000175161 (Ensembl)
CDKN1A	GeneProduct	ENSG00000124762 (Ensembl)
COL21A1	GeneProduct	ENSG00000124749 (Ensembl)
CREBBP	GeneProduct	ENSG00000005339 (Ensembl)
CTSK	GeneProduct	ENSG00000143387 (Ensembl)
CUL2	GeneProduct	ENSG00000108094 (Ensembl)
Citrate cycle	Pathway	WP78 (WikiPathways)
DIAPH1	GeneProduct	ENSG00000131504 (Ensembl)
DVL2	GeneProduct	ENSG00000004975 (Ensembl)
EGLN1	GeneProduct	ENSG00000135766 (Ensembl)
EGLN2	GeneProduct	ENSG00000269858 (Ensembl)
EGLN3	GeneProduct	ENSG00000129521 (Ensembl)
ELOB	GeneProduct	ENSG00000103363 (Ensembl)
ELOC	GeneProduct	ENSG00000154582 (Ensembl)
EP300	GeneProduct	ENSG00000100393 (Ensembl)
EPAS1	GeneProduct	ENSG00000116016 (Ensembl)
FH	GeneProduct	ENSG00000091483 (Ensembl)
Fumarate	Metabolite	CHEBI:18012 (ChEBI)
HIF1A	GeneProduct	ENSG00000100644 (Ensembl)
Hypoxia		Q105688 (Wikidata)
L-malate	Metabolite	CHEBI:15589 (ChEBI)
PDGFB	GeneProduct	ENSG00000100311 (Ensembl)
PRCC	GeneProduct	ENSG00000143294 (Ensembl)
Pseudohypoxia		Q16966113 (Wikidata)
RBX1	GeneProduct	ENSG00000100387 (Ensembl)
SETD2	GeneProduct	ENSG00000181555 (Ensembl)
SFPQ	GeneProduct	ENSG00000116560 (Ensembl)
SLC2A1	GeneProduct	ENSG00000117394 (Ensembl)
TFE3	GeneProduct	ENSG00000068323 (Ensembl)
TFEB	GeneProduct	ENSG00000112561 (Ensembl)
TGFA	GeneProduct	ENSG00000163235 (Ensembl)
TGFB1	GeneProduct	ENSG00000105329 (Ensembl)
TGFB2	GeneProduct	ENSG00000092969 (Ensembl)
TGFB3	GeneProduct	ENSG00000119699 (Ensembl)
TGFb signaling pathway	Pathway	WP560 (WikiPathways)
VEGF signaling	Pathway	WP3888 (WikiPathways)
VEGFA	GeneProduct	ENSG00000112715 (Ensembl)
VHL	GeneProduct	ENSG00000134086 (Ensembl)
oxygen	Metabolite	CHEBI:25805 (ChEBI)

Annotated Interactions

No annotated interactions