Hedgehog signaling pathway (Homo sapiens)

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1HH-producing cellNucleusActivated formDegradationCiliumHH-recieving cellCytoplasmSMOCSNK1A1CSNK1G2PTCH1CSNK1A1LCSNK1ESUFUKIF3ACSNK1DARRB1FBXL17EVCCSNK1G1GLI1PRKACACSNK1G3HHIPGAS1GRK2DHHSHHIHHPTCH2HHIPPTCH1PTCH2UbUbSMURF1SMURF2LRP2CDONBOCSMOEVC2PRKACBPRKACGGRK3ARRB2GLI2GLI3GLI1GLI2GLI3KIF7GPR161GPR161SUFUUbDegradationSPOPSPOPLCUL3SPOPSPOPLCUL3GLI1GLI2GLI3PTCH1PTCH2CCND1CCND2BCL2DegradationSMO


Description

In the absence of the Hh ligand, the receptor PTCH (Patched) acts to prevent high expression and activity of SMO (Smoothened). When Hh is bound, the repression of SMO is relieved which leads to activation of the GLI transcription factors: activators Gli1 and Gli2 and repressor Gli3. Activated GLI then controls the transcription of hedgehog target genes. Pathway adapted from KEGG

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Ontology Terms

 

Bibliography

  1. Raducu M, Fung E, Serres S, Infante P, Barberis A, Fischer R, Bristow C, Thézénas ML, Finta C, Christianson JC, Buffa FM, Kessler BM, Sibson NR, Di Marcotullio L, Toftgård R, D'Angiolella V; ''SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.''; EMBO J, 2016 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
127354view18:42, 20 September 2023Khanspersupdated ub site
117749view12:47, 22 May 2021EweitzModified title
106507view20:32, 5 September 2019KhanspersModified description
105491view05:46, 8 August 2019KhanspersModified description
105477view05:23, 8 August 2019KhanspersModified description
96941view20:00, 20 April 2018Khanspersedit board height
96859view23:36, 14 April 2018AlexanderPicoOntology Term : 'signaling pathway' added !
96788view19:23, 6 April 2018KhanspersOntology Term : 'signaling pathway pertinent to development' added !
96787view19:22, 6 April 2018KhanspersOntology Term : 'Hedgehog signaling pathway' added !
96786view19:22, 6 April 2018KhanspersModified description
96785view19:21, 6 April 2018Khansperschanged board height
96784view19:21, 6 April 2018KhanspersModified title
96783view19:20, 6 April 2018KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ARRB1GeneProductENSG00000137486 (Ensembl)
ARRB2GeneProductENSG00000141480 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BOCGeneProductENSG00000144857 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CCND2GeneProductENSG00000118971 (Ensembl)
CDONGeneProductENSG00000064309 (Ensembl)
CSNK1A1GeneProductENSG00000113712 (Ensembl)
CSNK1A1LGeneProductENSG00000180138 (Ensembl)
CSNK1DGeneProductENSG00000141551 (Ensembl)
CSNK1EGeneProductENSG00000213923 (Ensembl)
CSNK1G1GeneProductENSG00000169118 (Ensembl)
CSNK1G2GeneProductENSG00000133275 (Ensembl)
CSNK1G3GeneProductENSG00000151292 (Ensembl)
CUL3GeneProductENSG00000036257 (Ensembl)
DHHGeneProductENSG00000139549 (Ensembl)
EVC2GeneProductENSG00000173040 (Ensembl)
EVCGeneProductEVC (HGNC)
FBXL17GeneProductENSG00000145743 (Ensembl)
GAS1GeneProductENSG00000180447 (Ensembl)
GLI1GeneProductENSG00000111087 (Ensembl)
GLI2GeneProductENSG00000074047 (Ensembl)
GLI3GeneProductENSG00000106571 (Ensembl)
GPR161GeneProductENSG00000143147 (Ensembl)
GRK2GeneProductENSG00000173020 (Ensembl)
GRK3GeneProductENSG00000100077 (Ensembl)
HHIPGeneProductENSG00000164161 (Ensembl)
IHHGeneProductENSG00000163501 (Ensembl)
KIF3AGeneProductENSG00000131437 (Ensembl)
KIF7GeneProductENSG00000166813 (Ensembl)
LRP2GeneProductENSG00000081479 (Ensembl)
PRKACAGeneProductENSG00000072062 (Ensembl)
PRKACBGeneProductENSG00000142875 (Ensembl)
PRKACGGeneProductENSG00000165059 (Ensembl)
PTCH1GeneProductENSG00000185920 (Ensembl)
PTCH2GeneProductENSG00000117425 (Ensembl)
SHHGeneProductENSG00000164690 (Ensembl)
SMOGeneProductENSG00000128602 (Ensembl)
SMURF1GeneProductENSG00000198742 (Ensembl)
SMURF2GeneProductENSG00000108854 (Ensembl)
SPOPGeneProductENSG00000121067 (Ensembl)
SPOPLGeneProductENSG00000144228 (Ensembl)
SUFUGeneProductENSG00000107882 (Ensembl)

Annotated Interactions

No annotated interactions

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