Trans-sulfuration pathway (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none SpontaneousGlutathione5-Methyl-THFCreatinine5-Glutamyl taurineS-Adenosylhomocysteine (SAH)SulfiteS-Adenosylmethionine (SAMe)PhosphocreatinePyruvate metabolismPropionylcarnitineADPBAAT2-HydroxybutyrateL-CysteineTetrahydrofolate (THF)CreatineL-Methionine2-Ketobutyric acidCDO1L-Glutamate3-SulfinoalanineTaurine3-sulfolactateTaurocholateSOCBS3-SulfinopyruvateL-HomocysteineL-CystathionineATPPropionyl-CoAL-CysteateCRATPyruvateHypotaurineCTHCKMCKMT1ACKBCKMT1BCKMT2MAT2BMAT2AMAT1AGGT1GGT6GGT7GGT5LDHALDHCLDHAL6ALDHAL6BLDHBAHCYAHCYL1AHCYL2DBTBCKDHADLDBCKDHBMTRBHMTGOT1MPSTGCLMGCLCGAD1GAD2GADL1CSADGOT2GOT1DNMT1DNMT3ADNMT3BDNMT3LCBSCTHMDH1MDH2GSSPhosphateName: Trans-sulfuration pathwayOrganism: Homo sapiens


Description

Trans-sulfuration pathway, the pathway of production of GSH from S-adenosylmethionine (SAMe). Evidences have been showed that this pathway was perturbed in liver toxicity studies.

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Quality Tags

Image:MissingXref.pngAnnotate nodes

Ontology Terms

Disease : COVID-19
Cell Type : epithelial cell
 

Bibliography

  1. Beger RD, Sun J, Schnackenberg LK.; ''Metabolomics approaches for discovering biomarkers of drug-induced hepatotoxicity and nephrotoxicity''; doi: 10.1016/j.taap.2009.11.019, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
138523view01:50, 18 April 2025EweitzAlign interactions
138522view01:49, 18 April 2025EweitzRefine alignment
138521view01:49, 18 April 2025EweitzRefine interactions, standardize case
138520view01:47, 18 April 2025EweitzEconomize layout
138519view01:41, 18 April 2025EweitzDecrease node height
138512view15:36, 17 April 2025Ash iyerupdated datanodes (pathway nodes and labels)
138507view15:20, 12 April 2025EweitzTailor node dimensions
138506view15:18, 12 April 2025EweitzEconomize layout
138505view15:16, 12 April 2025EweitzEconomize layout
138504view14:59, 12 April 2025EweitzFix typo
138503view14:58, 12 April 2025EweitzEconomize layout
138502view14:52, 12 April 2025EweitzRemove obsolete metadata
138501view14:49, 12 April 2025EweitzFix interactions
138500view14:46, 12 April 2025EweitzFix interactions
138499view14:39, 12 April 2025EweitzFix interactions
138498view14:31, 12 April 2025EweitzFix interactions
138497view14:26, 12 April 2025EweitzEconomize layout
106183view12:08, 16 August 2019MaintBotHMDB identifier normalization
102689view15:32, 19 January 2019FehrhartOntology Term : 'hepatocyte' added !
102688view15:31, 19 January 2019FehrhartOntology Term : 'sulfur metabolic pathway' added !
102572view16:22, 8 January 2019EgonwFixed a KEGG identifier (one too many zeros)
97377view13:39, 12 May 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
97373view09:40, 12 May 2018EgonwFixed a faulty data source where the gene ID was a label (of a metabolite, it seems). Fixes RDF loading.
96816view02:50, 10 April 2018Dipa179New pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
2-HydroxybutyrateMetaboliteCHEBI:50613 (ChEBI)
2-Ketobutyric acidMetaboliteCHEBI:30831 (ChEBI)
3-SulfinoalanineMetaboliteHMDB0000996 (HMDB)
3-SulfinopyruvateMetaboliteCHEBI:1665 (ChEBI)
3-sulfolactateMetaboliteCHEBI:58738 (ChEBI)
5-Glutamyl taurineGeneProduct
5-Methyl-THFMetaboliteC00440 (KEGG Compound)
ADPMetaboliteC00008 (KEGG Compound)
AHCYProtein191 (Entrez Gene)
AHCYL1Protein10768 (Entrez Gene)
AHCYL2Protein23382 (Entrez Gene)
ATPMetaboliteC00002 (KEGG Compound)
BAATGeneProduct570 (Entrez Gene)
BCKDHAGeneProduct593 (Entrez Gene)
BCKDHBGeneProduct594 (Entrez Gene)
BHMTGeneProduct635 (Entrez Gene)
CBSGeneProduct875 (Entrez Gene)
CBSGeneProductP32929 (Uniprot-TrEMBL)
CDO1GeneProduct1036 (Entrez Gene)
CKBGeneProduct1152 (Entrez Gene)
CKMGeneProduct1158 (Entrez Gene)
CKMT1AGeneProduct548596 (Entrez Gene)
CKMT1BGeneProduct1159 (Entrez Gene)
CKMT2GeneProduct1160 (Entrez Gene)
CRATGeneProduct1384 (Entrez Gene)
CSADGeneProduct51380 (Entrez Gene)
CTHGeneProduct1491 (Entrez Gene)
CreatineMetaboliteHMDB0000064 (HMDB)
CreatinineMetaboliteHMDB0000562 (HMDB)
DBTGeneProduct1629 (Entrez Gene)
DLDGeneProduct1738 (Entrez Gene)
DNMT1GeneProduct1786 (Entrez Gene)
DNMT3AGeneProduct1788 (Entrez Gene)
DNMT3BGeneProduct1789 (Entrez Gene)
DNMT3LGeneProduct29947 (Entrez Gene)
GAD1GeneProduct2571 (Entrez Gene)
GAD2GeneProduct2572 (Entrez Gene)
GADL1GeneProduct339896 (Entrez Gene)
GCLCGeneProduct2729 (Entrez Gene)
GCLMGeneProduct2730 (Entrez Gene)
GGT1GeneProduct2678 (Entrez Gene)
GGT5GeneProduct2687 (Entrez Gene)
GGT6GeneProduct124975 (Entrez Gene)
GGT7GeneProduct2686 (Entrez Gene)
GOT1GeneProduct2805 (Entrez Gene)
GOT2GeneProduct2806 (Entrez Gene)
GSSGeneProduct2937 (Entrez Gene)
GlutathioneMetaboliteC00051 (KEGG Compound)
HypotaurineMetaboliteC00519 (KEGG Compound)
L-CystathionineMetaboliteHMDB0000099 (HMDB)
L-CysteateMetaboliteCHEBI:17285 (ChEBI)
L-CysteineMetaboliteC00097 (KEGG Compound)
L-GlutamateMetaboliteC00025 (KEGG Compound)
L-HomocysteineMetaboliteC00155 (KEGG Compound)
L-MethionineMetaboliteC00073 (KEGG Compound)
LDHAGeneProduct3939 (Entrez Gene)
LDHAL6AGeneProduct160287 (Entrez Gene)
LDHAL6BGeneProduct92483 (Entrez Gene)
LDHBGeneProduct3945 (Entrez Gene)
LDHCGeneProduct3948 (Entrez Gene)
MAT1AGeneProduct4143 (Entrez Gene)
MAT2AGeneProduct4144 (Entrez Gene)
MAT2BGeneProduct27430 (Entrez Gene)
MDH1GeneProduct4190 (Entrez Gene)
MDH2GeneProduct4191 (Entrez Gene)
MPSTGeneProduct4357 (Entrez Gene)
MTRGeneProduct4548 (Entrez Gene)
PhosphateMetaboliteC00009 (KEGG Compound)
PhosphocreatineMetaboliteHMDB0001511 (HMDB)
Propionyl-CoAMetaboliteHMDB0001275 (HMDB)
PropionylcarnitineMetaboliteHMDB0000824 (HMDB)
Pyruvate metabolismPathway
PyruvateMetaboliteC00022 (KEGG Compound)
S-Adenosylhomocysteine (SAH)MetaboliteC00021 (KEGG Compound)
S-Adenosylmethionine (SAMe)MetaboliteC00019 (KEGG Compound)
SOProteinF8VX56 (Uniprot-TrEMBL)
SulfiteMetaboliteHMDB0000240 (HMDB)
TaurineMetaboliteHMDB0000251 (HMDB)
TaurocholateMetaboliteCHEBI:28865 (ChEBI)
Tetrahydrofolate (THF)MetaboliteC00101 (KEGG Compound)

Annotated Interactions

No annotated interactions

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