Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer (Homo sapiens)
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Description
The TP53-uc.339-miRNA-CCNE2 network. TP53 directly inhibits the expression of ultraconserved region 339 (us339). Ultraconserved region 339 functions as an “entrapper” for CCNE2 targeting miR-339, -663b, and -95 leading to up-regulation of CCNE2 and increased tumor growth and migration.
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- Vannini I, Wise PM, Challagundla KB, Plousiou M, Raffini M, Bandini E, Fanini F, Paliaga G, Crawford M, Ferracin M, Ivan C, Fabris L, Davuluri RV, Guo Z, Cortez MA, Zhang X, Chen L, Zhang S, Fernandez-Cymering C, Han L, Carloni S, Salvi S, Ling H, Murtadha M, Neviani P, Gitlitz BJ, Laird-Offringa IA, Nana-Sinkam P, Negrini M, Liang H, Amadori D, Cimmino A, Calin GA, Fabbri M; ''Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs.''; Nat Commun, 2017 PubMed Europe PMC Scholia
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External references
DataNodes
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Name  | Type | Database reference | Comment |
|---|---|---|---|
| CCNE2 | GeneProduct | ENSG00000175305 (Ensembl)  | |
| MIR339 | Rna | ENSG00000199023 (Ensembl) | |
| MIR663B | Rna | ENSG00000221288 (Ensembl) | |
| MIR95 | Rna | ENSG00000207807 (Ensembl) | |
| TP53 | GeneProduct | ENSG00000141510 (Ensembl) | |
| uc339 (Entraper1) | GeneProduct |
Annotated Interactions
No annotated interactions
