Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer (Homo sapiens)
From WikiPathways
Description
The TP53-uc.339-miRNA-CCNE2 network. TP53 directly inhibits the expression of ultraconserved region 339 (us339). Ultraconserved region 339 functions as an “entrapper” for CCNE2 targeting miR-339, -663b, and -95 leading to up-regulation of CCNE2 and increased tumor growth and migration.
Quality Tags
 | Approved version |
 | Annotate nodes |
 | Community: CPTAC |
 |  |
Ontology Terms
Saving...Pathway Ontology : microRNA pathway cancer pathway
Disease : cancer
Bibliography
- Vannini I, Wise PM, Challagundla KB, Plousiou M, Raffini M, Bandini E, Fanini F, Paliaga G, Crawford M, Ferracin M, Ivan C, Fabris L, Davuluri RV, Guo Z, Cortez MA, Zhang X, Chen L, Zhang S, Fernandez-Cymering C, Han L, Carloni S, Salvi S, Ling H, Murtadha M, Neviani P, Gitlitz BJ, Laird-Offringa IA, Nana-Sinkam P, Negrini M, Liang H, Amadori D, Cimmino A, Calin GA, Fabbri M; ''Transcribed ultraconserved region 339 promotes carcinogenesis by modulating tumor suppressor microRNAs.''; Nat Commun, 2017 PubMed Europe PMC Scholia
History
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External references
DataNodes
| View all... |
Name  | Type | Database reference | Comment |
|---|---|---|---|
| CCNE2 | GeneProduct | ENSG00000175305 (Ensembl)  | |
| MIR339 | Rna | ENSG00000199023 (Ensembl) | |
| MIR663B | Rna | ENSG00000221288 (Ensembl) | |
| MIR95 | Rna | ENSG00000207807 (Ensembl) | |
| TP53 | GeneProduct | ENSG00000141510 (Ensembl) | |
| uc339 (Entraper1) | GeneProduct |
Annotated Interactions
No annotated interactions
