Inhibition of exosome biogenesis and secretion by manumycin A in CRPC cells (Homo sapiens)

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Description

Schematic representation of inhibition of exosome biogenesis and secretion by the antibiotic Manumycin A (MA) in castration-resistant prostate cancer cells (CRPC) cells. The inhibition of Ras/Raf/ERK1/2 pathway by MA leads to transcriptional down-regulation of hnRNP H1. A decrease in hnRNP H1 transcripts leads to inhibition of exosome biogenesis and secretion by suppressing ALIX and RAB27A. Description from Datta et al.

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Bibliography

  1. Datta A, Kim H, Lal M, McGee L, Johnson A, Moustafa AA, Jones JC, Mondal D, Ferrer M, Abdel-Mageed AB; ''Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells.''; Cancer Lett, 2017 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
142102view12:00, 1 December 2025EweitzClear deprecated metadata rendering
138745view01:06, 1 May 2025EweitzModified title
138744view00:59, 1 May 2025EweitzFix typo, add identifier for metabolite
134835view12:48, 27 July 2024EweitzOntology Term : 'drug pathway' added !
134834view12:47, 27 July 2024EweitzModified description
134833view12:45, 27 July 2024EweitzRefine legend
134832view12:42, 27 July 2024EweitzOntology Term : 'neoplastic cell' added !
97800view19:10, 8 June 2018KhanspersOntology Term : 'Ras family mediated signaling pathway' added !
97652view20:43, 31 May 2018KhanspersModified title
97651view20:09, 31 May 2018KhanspersOntology Term : 'prostate cancer' added !
97650view20:08, 31 May 2018KhanspersModified description
97649view20:06, 31 May 2018KhanspersNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ALIXGeneProductENSG00000170248 (Ensembl)
ARAFGeneProductENSG00000078061 (Ensembl)
BRAFGeneProductENSG00000157764 (Ensembl)
HGSGeneProductENSG00000185359 (Ensembl)
HNRNPH1GeneProductENSG00000169045 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MRASGeneProductENSG00000158186 (Ensembl)
Manumycin AMetaboliteCHEBI:29623 (ChEBI)
NRASGeneProductENSG00000213281 (Ensembl)
RAB27AGeneProductENSG00000069974 (Ensembl)
RAB5AGeneProductENSG00000144566 (Ensembl)
RAB5BGeneProductENSG00000111540 (Ensembl)
RAB5CGeneProductENSG00000108774 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
RRAS2GeneProductENSG00000133818 (Ensembl)
RRASGeneProductENSG00000126458 (Ensembl)

Annotated Interactions

No annotated interactions

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