miRNA degrading enzymes (Homo sapiens)
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Description
MicroRNAs (miRNAs) are short RNAs that are important for the regulation of numerous biological processes. Accordingly, the expression of miRNAs is itself tightly controlled by mechanisms acting at the level of transcription as well as processing of miRNA precursors. Recently, active degradation of mature miRNAs has been identified as another mechanism that is important for miRNA homeostasis. In cultured human cells, ribosomal RNA processing protein 41 (RRP41) and polynucleotide phosphorylase (PNPT1) degrade specific miRNAs in the 3'-to-5'direction. (Adapted from Großhans H. et al 2012.)
Quality Tags
Ontology Terms
Bibliography
- Rüegger S, Großhans H; ''MicroRNA turnover: when, how, and why.''; Trends Biochem Sci, 2012 PubMed Europe PMC Scholia
- Zhang Z, Qin YW, Brewer G, Jing Q; ''MicroRNA degradation and turnover: regulating the regulators.''; Wiley Interdiscip Rev RNA, 2012 PubMed Europe PMC Scholia
History
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External references
DataNodes
Name | Type | Database reference | Comment |
---|---|---|---|
PNPT1 | GeneProduct | ENSG00000138035 (Ensembl) | |
RRP41 | GeneProduct | Q9NPD3 (Uniprot-TrEMBL) | |
XRN1 | GeneProduct | ENSG00000114127 (Ensembl) |
Annotated Interactions
No annotated interactions