miRNA role in immune response in sepsis (Homo sapiens)

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1Tissue hypo-perfusionKaposi sarcoma herpesvirus miR-K12-12Intravascular coagulationMAP3KsDegradationTLR4MIR146AMAP3K7HSP70MYD88IRAK1ICAM1MIR15Inflammatory responseLPSsFASTLR7IL1AMIRLET7EMIRLET7IMIR146BMIR223IRAK4TRAF6TAB2TAB1MIR146AMIR146BMIR155HGIKBKGCHUKIKBKBMIR223MIR16-1MIR16-2MIR199A1MIR199A2MIR126MIR9-1IRAK1IRAK4TRAF6IRAK1IRAK4TRAF6TRAF3TLR8MYD88MIR146BMIR149MIR200BMIR200CMIR203AMIR203BMIR758MAPK14MAPK8IRF5IRF1IRF7IkBIkBPRELANFKB2RELBc-RELNFKB1RELANFKB2RELBc-RELNFKB1NO-inducedvasodilation-hypotensionCOX2-inducedhypotensionTissue injuryMultiple organ failureNeutrophil Infiltration/activationEndothelial permeabilityCXCL8CCL3CCL4VCAM1ELANELCN2HSP70GZMBsFASLNucleusAnti-inflammatory cytokinesIL6MIR21MIR29AMIR145MIR155TNFIL10Pro-inflammatory cytokinesIL10MIR16-1MIR16-2MIR106AMIR106BMIR4461MIR29AMIR16-1MIR16-2MIR19AMIR125B1MIR125B2MIR155MIR187MIR122TNFIL6MIRLET7IMIR146AMIR187Hypoxia


Description

Involvement of cellular miRNAs in the signaling pathway of the immune response in sepsis. Cellular immune miRNAs target important components of the NF-κB signaling pathway at different levels regulating the inflammatory response in the pathogenesis of sepsis. Lower part of the figure illustrates the pathophysiological events in sepsis that lead to tissue injury and subsequent multiple organs failure.

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Bibliography

  1. Giza DE, Fuentes-Mattei E, Bullock MD, Tudor S, Goblirsch MJ, Fabbri M, Lupu F, Yeung SJ, Vasilescu C, Calin GA; ''Cellular and viral microRNAs in sepsis: mechanisms of action and clinical applications.''; Cell Death Differ, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
128743view04:58, 21 February 2024EweitzUpgrade disease node, standardize case
124845view21:01, 14 December 2022EweitzModified title
123505view04:59, 29 July 2022EgonwMade a pathway clickable
101725view21:22, 1 November 2018Khanspersminor update
99016view21:13, 23 October 2018Khanspersupdated interaction
99015view21:02, 23 October 2018KhanspersAdded graphic from fig 4 from the same paper, added nucleus and moved existing TNF section
99014view00:00, 23 October 2018Khanspersimproved layout
98988view21:07, 19 October 2018KhanspersModified title
98402view05:48, 1 September 2018EgonwReplaced a secondary ChEBI ID with primary ID.
98392view23:54, 30 August 2018KhanspersOntology Term : 'nuclear factor kappa B signaling pathway' added !
98391view23:54, 30 August 2018KhanspersOntology Term : 'immune response pathway' added !
98390view23:48, 30 August 2018KhanspersModified description
98389view23:46, 30 August 2018KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CCL3GeneProductENSG00000277632 (Ensembl)
CCL4GeneProductENSG00000275302 (Ensembl)
CHUKGeneProductENSG00000213341 (Ensembl)
CXCL8GeneProductENSG00000169429 (Ensembl)
ELANEGeneProductENSG00000197561 (Ensembl)
GZMBGeneProductENSG00000100453 (Ensembl)
HSP70GeneProduct
HypoxiaQ105688 (Wikidata)
ICAM1GeneProductENSG00000090339 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl)
IL10GeneProductENSG00000136634 (Ensembl)
IL1AGeneProductENSG00000115008 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
IRAK1GeneProductENSG00000184216 (Ensembl)
IRAK4GeneProductENSG00000198001 (Ensembl)
IRF1GeneProductENSG00000125347 (Ensembl)
IRF5GeneProductENSG00000128604 (Ensembl)
IRF7GeneProductENSG00000185507 (Ensembl)
IkBGeneProductP25963 (Uniprot-TrEMBL) IkB Not Specified
Inflammatory responsePathwayWP453 (WikiPathways)
LCN2GeneProductENSG00000148346 (Ensembl)
LPSMetaboliteCHEBI:16412 (ChEBI)
MAP3K7GeneProductENSG00000135341 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MIR106AGeneProductENSG00000284157 (Ensembl)
MIR106BGeneProductENSG00000208036 (Ensembl)
MIR122GeneProductENSG00000284440 (Ensembl)
MIR125B1GeneProductENSG00000207971 (Ensembl)
MIR125B2GeneProductENSG00000207863 (Ensembl)
MIR126GeneProductENSG00000199161 (Ensembl)
MIR145GeneProductENSG00000276365 (Ensembl)
MIR146ARna
MIR146BGeneProductENSG00000202569 (Ensembl)
MIR149GeneProductENSG00000207611 (Ensembl)
MIR15Rna
MIR155GeneProductENSG00000283904 (Ensembl)
MIR155HGGeneProductENSG00000234883 (Ensembl)
MIR16-1GeneProductENSG00000208006 (Ensembl)
MIR16-2GeneProductENSG00000198987 (Ensembl)
MIR187GeneProductENSG00000207797 (Ensembl)
MIR199A1GeneProductENSG00000207752 (Ensembl)
MIR199A2GeneProductENSG00000208024 (Ensembl)
MIR19AGeneProductENSG00000284204 (Ensembl)
MIR200BGeneProductENSG00000207730 (Ensembl)
MIR200CGeneProductENSG00000207713 (Ensembl)
MIR203AGeneProductENSG00000207568 (Ensembl)
MIR203BGeneProductENSG00000283165 (Ensembl)
MIR21GeneProductENSG00000284190 (Ensembl)
MIR223GeneProductENSG00000274536 (Ensembl)
MIR29AGeneProductMIR29A (HGNC)
MIR4461GeneProductENSG00000263963 (Ensembl)
MIR758GeneProductENSG00000211582 (Ensembl)
MIR9-1GeneProductENSG00000207933 (Ensembl)
MIRLET7ERnaENSG00000198972 (Ensembl)
MIRLET7IGeneProductENSG00000199179 (Ensembl)
MYD88GeneProductENSG00000172936 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKB2GeneProductENSG00000077150 (Ensembl)
RELAGeneProduct5970 (Entrez Gene)
RELBGeneProduct5971 (Entrez Gene)
TAB1GeneProductENSG00000100324 (Ensembl)
TAB2GeneProductENSG00000055208 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
TLR7GeneProductENSG00000196664 (Ensembl)
TLR8GeneProductENSG00000101916 (Ensembl)
TNFGeneProductENSG00000232810 (Ensembl)
TRAF3GeneProductENSG00000131323 (Ensembl)
TRAF6GeneProductENSG00000175104 (Ensembl)
VCAM1GeneProductENSG00000162692 (Ensembl)
c-RELGeneProduct5966 (Entrez Gene)
sFASGeneProduct
sFASLGeneProduct

Annotated Interactions

No annotated interactions

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