ncRNAs in Wnt signaling in hepatocellular carcinoma (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none ScaffoldNucleusTranscriptional activationFrizzled ligandsWNT3AWNT7AWNT11WNT1WNT5BWNT2WNT2BWNT6WNT5AWNT16WNT4WNT3WNT10BWNT7BWNT10AWNT16Epithelial-mesenchymal transitionCancer stem cellDANCRMIR214lncTCF7MIR1247CSNK1ESOX7CTNNB1UFC1lncRNA-LALR1KREM1MIR452CHD8lnc-beta-catm26S proteasome degradationHBX-LINE1ELAVL1EZH2ROR1RYKROR2CSNK2BCSNK2A1CSNK2A3CSNK2A2FRAT1FRAT2LRP5LRP6GSK3BAPCAXIN1DVL3DVL2DVL1PLAUCCND1JUNCCND3FOSL1MYCCCND2CSNK1A1CSNK1A1LPPPPPLEF1TCF7L1PPTCF7L2TCF7CTNNB1FZD3FZD8FZD10FZD7FZD4FZD1FZD6FZD5FZD9FZD2PPPCTNNB1PUbPPCTNNB1DKK1DKK2DKK4SOSTSERPINF1SFRP1SFRP2SFRP4SFRP5NOTUMCER1WIF1PORCNNKD1NKD2CXXC4SENP2PNLKCTNNBIP1SOX17CTBP1CTBP2MIR15BMIR195MTDHMIR18AKLF4MIR320AName: ncRNAs in Wnt signaling in hepatocellular carcinomaOrganism: Homo sapiens


Description

This pathway is based on the [Wnt signaling pathway](https://www.wikipathways.org/pathways/WP428.html) with information on lncRNA involvement in hepatocellular carcinoma from Fig 3 in Klingenberg et al. Phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.

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Quality Tags

Image:Curated.pngApproved version
Image:MissingXref.pngAnnotate nodes
Image:Wplogo_31.pngCommunity: CPTAC

Ontology Terms

Bibliography

  1. Vasuri F, Visani M, Acquaviva G, Brand T, Fiorentino M, Pession A, Tallini G, D'Errico A, de Biase D; ''Role of microRNAs in the main molecular pathways of hepatocellular carcinoma.''; World J Gastroenterol, 2018 PubMed Europe PMC Scholia
  2. Nusse R; ''Wnt signaling in disease and in development.''; Cell Res, 2005 PubMed Europe PMC Scholia
  3. Klingenberg M, Matsuda A, Diederichs S, Patel T; ''Non-coding RNA in hepatocellular carcinoma: Mechanisms, biomarkers and therapeutic targets.''; J Hepatol, 2017 PubMed Europe PMC Scholia
  4. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E; ''PhosphoSitePlus, 2014: mutations, PTMs and recalibrations.''; Nucleic Acids Res, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137048
Approved
view22:22, 26 February 2025KhanspersModified description
134815view11:21, 27 July 2024EweitzOntology Term : 'stem cell' added !
134814view11:20, 27 July 2024EweitzModified description
134813view11:20, 27 July 2024EweitzFix truncated text, standardize case
134812view11:06, 27 July 2024EweitzModified title
127463view01:20, 7 October 2023KhanspersUpdated phosphosites
127241view00:21, 26 August 2023KhanspersAdded lit ref and removed empty comments
123504
CPTAC
view04:59, 29 July 2022EgonwMade a pathway clickable
108198view10:58, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
108197view10:58, 29 November 2019FehrhartOntology Term : 'hepatocyte' added !
105488view05:44, 8 August 2019KhanspersModified description
105472view05:19, 8 August 2019KhanspersModified description
103459view23:59, 4 March 2019KhanspersAdded miRNA regulation from Vasuri et al
98467view19:13, 7 September 2018KhanspersModified description
98462view18:04, 7 September 2018KhanspersModified title
98461view18:01, 7 September 2018KhanspersModified description
98460view18:01, 7 September 2018KhanspersOntology Term : 'hepatocellular carcinoma' added !
98459view18:00, 7 September 2018KhanspersOntology Term : 'altered Wnt signaling pathway' added !
98458view18:00, 7 September 2018KhanspersModified description
98457view17:54, 7 September 2018Khanspersadded lit ref
98456view17:53, 7 September 2018KhanspersNew pathway

External references

DataNodes

View all...
Name  â†“Type  â†“Database reference  â†“Comment  â†“
26S proteasome degradationPathwayWP183 (WikiPathways)
APCGeneProduct324 (Entrez Gene)
AXIN1GeneProduct8312 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CER1GeneProductENSG00000147869 (Ensembl)
CHD8GeneProductENSG00000100888 (Ensembl)
CSNK1A1GeneProductENSG00000113712 (Ensembl)
CSNK1A1LGeneProductENSG00000180138 (Ensembl)
CSNK1EGeneProduct1454 (Entrez Gene)
CSNK2A1GeneProductENSG00000101266 (Ensembl)
CSNK2A2GeneProductENSG00000070770 (Ensembl)
CSNK2A3GeneProductENSG00000254598 (Ensembl)
CSNK2BGeneProductENSG00000204435 (Ensembl)
CTBP1GeneProductENSG00000159692 (Ensembl)
CTBP2GeneProductENSG00000175029 (Ensembl)
CTNNB1GeneProduct1499 (Entrez Gene)
CTNNBIP1GeneProductENSG00000178585 (Ensembl)
CXXC4GeneProductENSG00000168772 (Ensembl)
DANCRRnaENSG00000226950 (Ensembl)
DKK1GeneProductENSG00000107984 (Ensembl)
DKK2GeneProductENSG00000155011 (Ensembl)
DKK4GeneProductENSG00000104371 (Ensembl)
DVL1GeneProduct1855 (Entrez Gene)
DVL2GeneProduct1856 (Entrez Gene)
DVL3GeneProduct1857 (Entrez Gene)
ELAVL1GeneProductENSG00000066044 (Ensembl)
EZH2GeneProductENSG00000106462 (Ensembl)
FOSL1GeneProduct8061 (Entrez Gene)
FRAT1GeneProduct10023 (Entrez Gene)
FRAT2GeneProductENSG00000181274 (Ensembl)
FZD10GeneProduct11211 (Entrez Gene)
FZD1GeneProduct8321 (Entrez Gene)
FZD2GeneProduct2535 (Entrez Gene)
FZD3GeneProduct7976 (Entrez Gene)
FZD4GeneProduct6424 (Entrez Gene)
FZD5GeneProduct7855 (Entrez Gene)
FZD6GeneProduct8323 (Entrez Gene)
FZD7GeneProduct8324 (Entrez Gene)
FZD8GeneProduct8325 (Entrez Gene)
FZD9GeneProduct8326 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene) MOUSE:KG38 MOUSE
HBX-LINE1GeneProduct
JUNGeneProduct3725 (Entrez Gene)
KLF4GeneProductENSG00000136826 (Ensembl)
KREM1GeneProduct83999 (Entrez Gene)
LEF1GeneProductENSG00000138795 (Ensembl)
LRP5GeneProduct4041 (Entrez Gene)
LRP6GeneProduct4040 (Entrez Gene)
MIR1247GeneProductMIMAT0005899 (miRBase mature sequence)
MIR15BGeneProductMIMAT0000417 (miRBase mature sequence)
MIR18AGeneProductENSG00000283815 (Ensembl)
MIR195GeneProductMIMAT0000461 (miRBase mature sequence)
MIR214GeneProductMIR214 (HGNC)
MIR320AGeneProductENSG00000208037 (Ensembl)
MIR452GeneProductENSG00000283751 (Ensembl)
MTDHGeneProductENSG00000147649 (Ensembl)
MYCGeneProduct4609 (Entrez Gene)
NKD1GeneProductENSG00000140807 (Ensembl)
NKD2GeneProductENSG00000145506 (Ensembl)
NLKGeneProductENSG00000087095 (Ensembl)
NOTUMGeneProductENSG00000185269 (Ensembl)
PLAUGeneProduct5328 (Entrez Gene)
PORCNGeneProductENSG00000102312 (Ensembl)
ROR1GeneProduct4919 (Entrez Gene)
ROR2GeneProduct4920 (Entrez Gene)
RYKGeneProduct6259 (Entrez Gene)
SENP2GeneProductENSG00000163904 (Ensembl)
SERPINF1GeneProductENSG00000132386 (Ensembl)
SFRP1GeneProductENSG00000104332 (Ensembl)
SFRP2GeneProductENSG00000145423 (Ensembl)
SFRP4GeneProductENSG00000106483 (Ensembl)
SFRP5GeneProductENSG00000120057 (Ensembl)
SOSTGeneProductENSG00000167941 (Ensembl)
SOX17GeneProductENSG00000164736 (Ensembl)
SOX7GeneProductENSG00000171056 (Ensembl)
TCF7GeneProductENSG00000081059 (Ensembl)
TCF7L1GeneProductENSG00000152284 (Ensembl)
TCF7L2GeneProductENSG00000148737 (Ensembl)
UFC1Rna
WIF1GeneProductENSG00000156076 (Ensembl)
WNT10AGeneProduct80326 (Entrez Gene)
WNT10BGeneProduct7480 (Entrez Gene)
WNT11GeneProduct7481 (Entrez Gene)
WNT16GeneProduct51384 (Entrez Gene)
WNT1GeneProduct7471 (Entrez Gene)
WNT2GeneProduct7472 (Entrez Gene)
WNT2BGeneProduct7482 (Entrez Gene)
WNT3GeneProduct7473 (Entrez Gene)
WNT3AGeneProduct89780 (Entrez Gene)
WNT4GeneProduct54361 (Entrez Gene)
WNT5AGeneProduct7474 (Entrez Gene)
WNT5BGeneProduct81029 (Entrez Gene)
WNT6GeneProduct7475 (Entrez Gene)
WNT7AGeneProduct7476 (Entrez Gene)
WNT7BGeneProduct7477 (Entrez Gene)
lnc-beta-catmRna
lncRNA-LALR1Rna
lncTCF7Rna

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4336"
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