LTF danger signal response pathway (Homo sapiens)

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1DNANucleusTrauma or InfectionCytosolTREM1NFKB1IRAK4IL6MAPK1IFNBIL1ALTFTRAF6RAGEIFNACD14TNFIL8TLR4TLR2IRAK1IL1BMYD88


Description

Lactoferrin (LTF) activates NF-kB via danger signal receptors TLR2/4 and CD14. LTF may also activate NF-kB via additional receptors RAGE and TREM1.

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Ontology Terms

 

Bibliography

  1. Kruzel ML, Zimecki M, Actor JK; ''Lactoferrin in a Context of Inflammation-Induced Pathology.''; Front Immunol, 2017 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129212view01:37, 16 March 2024EweitzModified description
129197view16:41, 15 March 2024EgonwOntology Term : 'signaling pathway' added !
121699view03:40, 26 February 2022EweitzFix gene symbol
103756view23:29, 3 April 2019KhanspersModified description
103754view23:15, 3 April 2019Khanspersfixed unconnected interactions
102252view10:39, 13 December 2018LaurentVisual aspects
102242view13:29, 12 December 2018LaurentUpdated visual aspects
102241view13:22, 12 December 2018LaurentChanged visual aspects
102237view12:31, 12 December 2018LaurentModified description
102232view09:44, 12 December 2018LaurentName NFkB fixed
102231view09:43, 12 December 2018Laurenttypo in entrezgene ID NFkB fixed
102230view09:13, 12 December 2018LaurentModified title
102229view09:08, 12 December 2018LaurentNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CD14GeneProduct929 (Entrez Gene)
IFNAGeneProduct3439 (Entrez Gene)
IFNBGeneProduct3456 (Entrez Gene)
IL1AGeneProduct3552 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL8GeneProduct3576 (Entrez Gene)
IRAK1GeneProduct3654 (Entrez Gene)
IRAK4GeneProduct51135 (Entrez Gene)
LTFGeneProduct4057 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MYD88GeneProduct4615 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
RAGEGeneProduct177 (Entrez Gene)
TLR2GeneProduct7097 (Entrez Gene)
TLR4GeneProduct7099 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
TRAF6GeneProduct7189 (Entrez Gene)
TREM1GeneProduct54210 (Entrez Gene)

Annotated Interactions

No annotated interactions

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