DNA replication (Danio rerio)

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1, 2RNA primer-DNA primerUbiquitinp180RFC140Ubiquitinated Orc1RNA primer-DNA primer:origin duplex:PCNAATPGTPOrc2Mcm3Orc complexOrc2RFC382. Activation of the pre-replicative complexRFC40p58ATPCdc6Orc4Orc complexPrimasePCNA homotrimer1. Assembly of the pre-replicative complexRNA PrimerMcm2Orc4RNA primer-DNA primerCdc6ADPOrc3Mcm5p49Mcm 4,6,7 trimer forms and associatesdATPPhosphorylated Cdc6Cdt1Orc5Gemininp70Degraded by proteasome in cytosolCdc6Mcm10Cdt1Orc complexPhosphorylation of Mcm 2-7 complexOrc5with the replication forkDNA polymerase alpha: primase: origin complexOriginUbiquitinOrc1ATPUbiquitinated Cdc6ATPCdt1RFC Heteropentamer:RNA primer-DNA primer:Phosphorylated Orc1DNA PolymerasePre-replicative complexOrc3Mcm3Mcm6Orc5UTP3. DNA replication initiationRFC36DNA polymerase alpha: primase: origin complexOrc3RFC Heteropentamer:RNA primer-DNA primerMcm6Cdt1dGTPMcm4Orc2Mcm4aMcm5Orc3Cdt1Mcm7dCTPCdc6Mcm7RFC37Mcm2CTPOrc2Degraded by proteasome in cytosolPre-replicative complexADPOrc Complex4. Switching of origins to post-replicative state5. Leading/lagging strand synthesisOrc complexdUTPProcessive complexzgc:77827POLA1orc3lPOLE2ORC2zgc:85772zgc:77841ASKzgc:56264rfc5UBA52mcm4POLD1mcm3RFC1mcm5pcnaMCM10zgc:101602POLD4POLECDC6rpa1zgc:110727prim1MCM7UBCrpa2rfc3zgc:110810RPA4gmnnorc6zgc:56310orc1zgc:56598pold2CDT1POLD3mcm2rfc4MCM6POLA2


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: Wikipedia

Comments

GenMAPP notes 
http://www.genomeknowledge.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.genomeknowledge.org

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Quality Tags

Ontology Terms

 

Bibliography

  1. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  2. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116856view10:52, 14 May 2021EweitzModified title
91940view11:47, 6 April 2017LWackersUpdated annotations. In case Entrez ID did not properly crossref, replaced with Ensembl as long as that did not lack an Entrez ID.
77445view20:29, 8 September 2014MaintBot
71532view19:23, 17 October 2013MaintBotAutomated update of data sources
68674view05:32, 6 July 2013MaintBotUpdated to 2013 gpml schema
67162view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40847view22:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35217view15:49, 11 February 2010Thomasadded literature
35211view15:45, 11 February 2010ThomasModified description
35203view15:41, 11 February 2010ThomasModified description
34228view21:37, 9 December 2009MaintBotAutomatic update of empty xrefs
21628view11:32, 14 November 2008MaintBot[[Pathway:Danio rerio:DNA replication Reactome]] moved to [[Pathway:WP451]]: Moved to stable identifier
12008view08:43, 15 May 2008MaintBotAdded to category $category
19415view08:43, 15 May 2008D.KorenUploaded new pathway
12006view08:43, 15 May 2008KdahlquistUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ASKGeneProduct
CDC6GeneProductENSDARG00000009942 (Ensembl)
CDT1GeneProduct566787 (Entrez Gene)
MCM10GeneProduct553396 (Entrez Gene)
MCM6GeneProduct566409 (Entrez Gene)
MCM7GeneProduct192333 (Entrez Gene)
ORC2GeneProductENSDARG00000101465 (Ensembl)
POLA1GeneProductENSDARG00000045308 (Ensembl)
POLA2GeneProductENSDARG00000015070 (Ensembl)
POLD1GeneProduct556456 (Entrez Gene)
POLD3GeneProductENSDARG00000076169 (Ensembl)
POLD4GeneProduct
POLE2GeneProduct192320 (Entrez Gene)
POLEGeneProduct553405 (Entrez Gene)
RFC1GeneProductENSDARG00000054799 (Ensembl)
RPA4GeneProduct
UBA52GeneProduct641289 (Entrez Gene)
UBCGeneProductENSDARG00000102632 (Ensembl)
gmnnGeneProduct368320 (Entrez Gene)
mcm2GeneProduct192338 (Entrez Gene)
mcm3GeneProduct192323 (Entrez Gene)
mcm4GeneProduct337598 (Entrez Gene)
mcm5GeneProduct286747 (Entrez Gene)
orc1GeneProductENSDARG00000039217 (Ensembl)
orc3lGeneProduct334315 (Entrez Gene)
orc6GeneProduct324256 (Entrez Gene)
pcnaGeneProduct30678 (Entrez Gene)
pold2GeneProductENSDARG00000095046 (Ensembl)
prim1GeneProduct30440 (Entrez Gene)
rfc3GeneProduct259256 (Entrez Gene)
rfc4GeneProduct406435 (Entrez Gene)
rfc5GeneProduct445385 (Entrez Gene)
rpa1GeneProduct327491 (Entrez Gene)
rpa2GeneProduct65226 (Entrez Gene)
zgc:101602GeneProduct492768 (Entrez Gene)
zgc:110727GeneProduct407653 (Entrez Gene)
zgc:110810GeneProduct503748 (Entrez Gene)
zgc:56264GeneProduct406695 (Entrez Gene)
zgc:56310GeneProduct393196 (Entrez Gene)
zgc:56598GeneProduct406715 (Entrez Gene)
zgc:77827GeneProduct406479 (Entrez Gene)
zgc:77841GeneProduct322059 (Entrez Gene)
zgc:85772GeneProduct406462 (Entrez Gene)

Annotated Interactions

No annotated interactions
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