TNF-alpha NF-kB signaling pathway (Rattus norvegicus)

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ECDeubiquitinationDesumoylationAutophosphorylationLigandReceptorCY ->NUCY ->NUCytoplasmExtracellularPMEndosomeENProteins in a complex interactionPlasma membraneGolgi apparatusProteolytic cleavageRecruitmentMolecular associationUbiquitinationMolecule in the pathwayEnzyme complexCYEndoplasmic reticulumCY ->NUNUControlActivationDMethylationDemethylationPhosphorylationSumoylationERPalmitoylationCY ->NUInhibitionAccession Number: NetPath 9; cellmap:9MitochondrionDeacetylation(Protein-protein interaction)GODephosphorylationCY ->NUAcetylationMTGlycosylationTranslocationReaction through unknown mechanisms/moleculesNucleusPolr1cTraf2TRAF5TraddRipk1Map2k5PrkacaTAB3YWHAQNfkb1GeneChukRipk1Traf2UBCH5CFaddRelaTnfTbk1NfkbibGeneLrpprcCsnk2a1Psmd13RGD1561988TnfYwhaeNr2c2RelFblCasp2Cul1TraipCyldMap3k7ip2Fbxw11RELBTbk1Akt1Tnfrsf1aRelaPsmd6Ube2iHsp90ab1DapTraf3POLR1DHspb1Psmd1TnfCasp8Tnfrsf8SKP1ATraf6Cops3Nkiras1Traf4Rps6ka5Rps6kb1CflarTnfCasp8ap2Ptpn11Hdac1Birc3Kpna2Cav1GeneGsk3bNfkbiaPsmc3Gtf2iRelaCapn3CASP10Ripk3ChukTnip1IkbkgRGD1561333Usp2Polr1aNsmafTnfHIST3H3AlplNfkb2CrebbpKTN1RelGeneNfkbizIkbkeBtrcPrkczPmlKpna6Bcl3Psmd12Wdr68Mcm5Tnfrsf1aIQGAP2Map3k1Hdac6TankTnfrsf1aFlnaDpf2Psmc2Psmb5Birc2RELBAkap8Polr1bPEG3Ripk2Map3k14IkbkbPolr1eMap3k3POLRY2HUnc5clTnip2LOC685179Pdcd2PPP1R13LGnb2l1Gab1Trpc4apNr2c2Casp7TBKBP1Map3k3Bag4Birc3Mtif2TXLNARnf25NfkbieGene SymbolUsp11Ddx3xNkiras2Rpl4COMMD1SUMO1Zfand5Psmd3TRAF1IkbkgSrcNfkbiaAzi2Cd3eapTraf2RPS13BCL7ARPL6YwhabActl6aTRAF1Fkbp5Nfkb1Smarcb1Ube2d2Tnfrsf1bPkn1Pfdn2Stat1Csnk2a2NALP4YwhagKpna3TifaGlg1Psmc1Smarcc1Casp3Rps11Smarca4CraddPtk2Rnf216Fancd2Psmd7TraddMAP3K7IP1Kcnq1Hdac2Map3k8CDC34Faf1TnfAkt2Pebp1LOC681193Rpl30RelaTNFAIP3Traf4RGD1309922Pias3Cdc37PapolaTnfrsf1bMcm7YwhahG3bp2Smarce1Rasal2Tnfrsf11aNfkb1NfkbiaIkbkapTnfrsf1bPpp2caHsp90aa1YwhazMark2Birc2Csnk2bMap3k2


Description

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Comments

GenMAPP notes 
NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 85% conversion rate.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
117025view11:52, 16 May 2021EweitzModified title
69441view19:05, 8 July 2013MaintBotUpdated to 2013 gpml schema
67702view11:51, 26 June 2013DdiglesOntology Term : 'tumor necrosis factor mediated signaling pathway' added !
41766view02:41, 2 March 2011MaintBotRemoved redundant pathway information and comments
34134view19:31, 9 December 2009MaintBotAutomatic update of empty xrefs
32438view17:16, 15 August 2009MaintBotFixed text labels
32108view13:47, 14 August 2009MaintBotFixed group labels
31458view21:14, 13 August 2009MaintBotFixed text labels
30990view00:56, 30 July 2009MaintBotConverted from Homo sapiens
21642view11:32, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:WP457]]: Moved to stable identifier
8450view13:46, 7 January 2008MaintBot[[Pathway:Rat:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:Rattus norvegicus:TNF-alpha-NF-kB NetPath 9]]: Renaming species
7841view16:22, 18 December 2007MaintBotfixed category names
7309view12:42, 4 November 2007MaintBotAdded categories to GPML
6603view22:20, 22 May 2007A.Pandeygpml file for [[Rat:TNF-alpha-NF-kB_NetPath_9]]

External references

DataNodes

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Annotated Interactions

No annotated interactions
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