Aerobic glycolysis (Homo sapiens)

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ATPAMPO2eHHKGLUT3Applies to PKA and PKL; does not apply to PKMx 12.52PGABPGPYRGAPPGKENOATPGPILDHG6PLACCytosolExtracellular environmentPEPPK3PGHGLUF6PDHAPALDPFKGLUeGAPDHADPFBPPGMTPIATPADPAMP2NADPNADHHATPADPATPADPLACeNADNADHCytosolExtracellular environmentADPPATPO2x 12.5x 12.5x 3OXPHOSO2NADHMASx 2.5ADPPATPx 2.5x 2.5NADATPATPaseADPHPADPADPAKPYR1StimulationCatalysisConversionPathwayBranch pathway originatingfrom the glycolysisMetaboliteGlycolytic metaboliteEnzymeEnzyme or processNADPHATPChemicals; color codedfor better visualizationEffector of the reactionpointed atConversion of acatalysing chemicalMetaboliteMetabolite that is fixedin the computer modelLegend


Description

Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO- and H+. The free energy released in this process is used to form the ATP and NADH.

This pathway was made during a research project at the UMCG, concerning changed glycolytic fluxes during the Warburg Effect. It is an extended version of the glycolysis pathway (WP534), and is descriptive of the content that is provided in the computer model of Shestov et al (2014). A second version, containing the content of the model itself as well as the corresponding supplement and article, can be found here [1]

This pathway was uploaded to provide a high resolution version to readers of the thesis. Description and pathway adapted from [2]

Referred article: Shestov et al., 2014 [3]

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Bibliography

  1. Hüttemann M, Lee I, Samavati L, Yu H, Doan JW; ''Regulation of mitochondrial oxidative phosphorylation through cell signaling''; https://www.sciencedirect.com/science/article/pii/S0167488907002364?via%3Dihub, 2007
  2. Berg JM, Tymoczko JL, Stryer L; ''Biochemistry''; https://www.ncbi.nlm.nih.gov/books/NBK22395/, 2002
  3. Carbonell J, Felíu JE, Marco R, Sols A; ''Pyruvate kinase. Classes of regulatory isoenzymes in mammalian tissues.''; Eur J Biochem, 1973 PubMed Europe PMC Scholia
  4. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J; ''A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.''; Science, 2012 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129407view15:55, 11 April 2024Khanspersfixed unconnected interacations
129396view21:00, 8 April 2024Khanspersremoved enzymes for O2 and LAC transport, as these transports are passive.
128376view18:56, 3 February 2024Ash iyerLACT - added comments
128303view13:57, 30 January 2024EweitzFix metabolite labels with extraneous leading underscore
128302view13:51, 30 January 2024EweitzFix text occlusion, standardize node width
128301view13:43, 30 January 2024EweitzRefine legend, economize layout
128300view12:59, 30 January 2024EweitzEconomize layout
127017view09:25, 19 July 2023Ash iyerAK enzyme nomenclature added.
127016view09:24, 19 July 2023Ash iyerAK enzyme nomenclature added.
127009view21:24, 18 July 2023Khanspersremoved node fill color, added cell shape
126318view04:25, 21 April 2023EgonwRemoved duplicate reference info
126317view04:24, 21 April 2023EgonwLicense is CCZero
119264view07:52, 23 June 2021FinterlyAdded ISBN for book citation
117688view12:09, 22 May 2021EweitzModified title
107177view14:26, 17 September 2019MaintBotChEBI identifier normalization
106806view13:28, 17 September 2019MaintBotHMDB identifier normalization
105421view16:35, 7 August 2019DeSlRemoved unnecessary references.
105420view16:34, 7 August 2019DeSlUpdated lit. refs to remove weird characters.
105418view16:31, 7 August 2019DeSlConverted interactions in legend to graphical lines, to avoid unconnected lines warning.
104986view20:40, 27 June 2019KJanssenUpdated legend
104934view00:25, 26 June 2019AlexanderPicoModified title
104637view06:03, 7 June 2019EgonwIf there is no identifier, plz leave the Xref fields empty.
104617view08:09, 4 June 2019KJanssenModified description
104615view08:06, 4 June 2019KJanssen
104613view08:02, 4 June 2019KJanssenUpdated legend
104610view07:52, 4 June 2019KJanssenUpdated legend, minor changes in the pathway.
104607view07:18, 4 June 2019KJanssenModified title
104606view07:16, 4 June 2019KJanssenModified title
104601view16:53, 3 June 2019KJanssenModified description
104599view16:52, 3 June 2019KJanssenModified description
104598view16:51, 3 June 2019KJanssen
104597view16:48, 3 June 2019KJanssenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2PGAMetaboliteHMDB0000362 (HMDB)
3PGMetaboliteHMDB0000807 (HMDB)
ADPMetaboliteCHEBI:16761 (ChEBI)
AKGeneProduct2.7.4.3 (Enzyme Nomenclature)
ALDGeneProduct226 (Entrez Gene)
AMPMetaboliteCHEBI:16027 (ChEBI)
ATPMetaboliteCHEBI:15422 (ChEBI)
ATPaseGeneProduct
BPGMetaboliteHMDB0001270 (HMDB)
DHAPMetaboliteHMDB0001473 (HMDB)
ENOGeneProduct2023 (Entrez Gene)
EnzymeGeneProduct2821 (Entrez Gene) glucose-6-phosphate isomerase
F6PMetaboliteCHEBI:61527 (ChEBI)
FBPMetaboliteHMDB0001058 (HMDB)
G6PMetaboliteCHEBI:75052 (ChEBI) Glucose-6-Phosphate (2-)
GAPDHGeneProductENSG00000111640 (Ensembl)
GAPMetaboliteHMDB0001112 (HMDB)
GLUMetaboliteHMDB0000122 (HMDB)
GLUTGeneProduct6513 (Entrez Gene)
GLUeMetaboliteHMDB0000122 (HMDB)
GPIGeneProduct2821 (Entrez Gene) glucose-6-phosphate isomerase
HMetaboliteCHEBI:49637 (ChEBI)
HKGeneProduct3098 (Entrez Gene)
LACMetaboliteHMDB0000190 (HMDB)
LACeMetaboliteHMDB0000190 (HMDB)
LDH GeneProduct3939 (Entrez Gene)
MAS
MetaboliteMetabolite
NADMetaboliteCHEBI:15846 (ChEBI)
NADHMetaboliteCHEBI:16908 (ChEBI)
O2MetaboliteCHEBI:26689 (ChEBI)
O2eMetaboliteCHEBI:26689 (ChEBI)
OXPHOS
PMetaboliteCHEBI:28659 (ChEBI)
PEPMetaboliteHMDB0000263 (HMDB)
PFKGeneProduct5213 (Entrez Gene) Type your comment here
PGK GeneProduct5230 (Entrez Gene)
PGM GeneProduct5224 (Entrez Gene)
PKGeneProduct5315 (Entrez Gene)
PYRMetaboliteHMDB0000243 (HMDB)
PathwayPathway0 (WikiPathways)
TPIGeneProduct7167 (Entrez Gene)

Annotated Interactions

No annotated interactions

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