Measles virus infection (Homo sapiens)

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231LymphocyteDendritic cellFMitochondriaNucleusNucleusLegendMV genome RNAEpithelial cellT cellMeasles virusPeripheral blood lymphocyteEndosomeInhibition of T-cell proliferationMV RNACell cycle retardationMeasles virus entryand replicationInhibition of cell deathVirus genome replicationMeasles virusinfectionVirus buddingInhibition of the establishmentof an antiviral stateMeasles virus structural proteinDendritic cellapoptosisEscape from innateimmune systemRACK1RCHY1CD46HSPA6IL1AEIF2AK2IFNA2IL2RAFADDADARMAVSSTAT3HSPA1LBIDOAS1CD3DDDX58TRADDCSNK2BCDK2Cell CycleIFNA1EIF3HCSNK2A1NECTIN4EIF2AK3IFNA5IFNA16CSNK2A2IRF3p53 siganling pathwayJAK1EIF2AK1TLR2CDKN1BTNFAIP3CD28FASCYCSCASP8IFNA7TP53Ubiquitin-mediatedproteolysisHSPA8CCND1IL2IFNB1IFNA8RAB9ACSNK2A3PIK3CAIFNA10IRF9FASLGVIFNA4CBLBIFNA14FIFNA13IFNA6RIG-1-like receptorsignaling pathwayEIF2AK2HSPA1AEIF2AK1EIF2S1PIRF7BBC3EIF2AK4TLR7??EIF2AK4LPSIL6SLAMF1P5MSNCLEC4MCD209TLR4TRAF6TAB2IRAK1MAP3K7IRAK4MYD88MAPK10MAPK8MAPK9JUNFOSIL1BIL12AIL12B4IFIH1TRAF3TBK1IKBKEVPCVCNIFNA17IFNA21TLR9MYD88IRAK1IRAK4CHUKIKBKGIKBKBNFKB1NFKBIARELANFKB2IFNAR1IFNAR2TYK2JAK1STAT1STAT2VPCOAS2OAS3MX1EIF2AK3BADBAXBAK1BCL2BCL2L1APAF1CASP9CASP3ImmunosuppressionHMNPLRAB9BTP73PVCHSPA1BHSPA2HSPA2NPInhibited host translationFHHCDK4CDK6CCND2CCND3CCNE1CCNE2IL2RBIL2RGCD3ECD3GJAK3STAT5ASTAT5BPPPIK3CBPIK3CDPIK3R1PIK3R2PIK3R3Measles virus non-structural protein4Measles virus RNAIKBKGIKBKBPCHUKNFKB1RELANFKBIANFKBIBPPNFKBIANFKBIBUbiquitin-mediated proteolysisNFKB1RELAHNNSLAMF1FCGR2BIL12AIL12BSupression of inflammatory reactionsLipid RaftP6MNLHVCN


Description

The measles virus is a single-stranded, negative-sense virus that exclusively infects humans. The measles virus has two surface proteins responsible for binding and fusion to target cells: hemagglutinin (H) and membrane fusion protein (F). Multiple receptors have been identified to bind these surface proteins: CD46, SLAM, Nectin-4 and TLR. The viral proteins P, V and C suppress the innate immune response by inhibiting signaling for both type I IFN induction and JAK/STAT-mediated interferon-stimulated gene (ISG) induction. The virus also causes inhibition of IL-12 expression in dendritic cells, via H proteins on viral particles as well as N proteins from infected cells. This pathway is based on KEGG.

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Ontology Terms

 

Bibliography

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  1. Susanne Rauch, Oliver T. Fackler; ''Viruses, lipid rafts and signal transduction''; https://doi.org/10.1002/sita.200600113, 2007 DOI Scholia
  2. ''''; https://www.genome.jp/dbget-bin/www_bget?pathway+hsa05162,
  3. Servet-Delprat C, Vidalain PO, Azocar O, Le Deist F, Fischer A, Rabourdin-Combe C; ''Consequences of Fas-mediated human dendritic cell apoptosis induced by measles virus.''; J Virol, 2000 PubMed Europe PMC Scholia
  4. Mesman AW, Zijlstra-Willems EM, Kaptein TM, de Swart RL, Davis ME, Ludlow M, Duprex WP, Gack MU, Gringhuis SI, Geijtenbeek TB; ''Measles virus suppresses RIG-I-like receptor activation in dendritic cells via DC-SIGN-mediated inhibition of PP1 phosphatases.''; Cell Host Microbe, 2014 PubMed Europe PMC Scholia
  5. Noyce RS, Richardson CD; ''Nectin 4 is the epithelial cell receptor for measles virus.''; Trends Microbiol, 2012 PubMed Europe PMC Scholia
  6. Avota E, Müller N, Klett M, Schneider-Schaulies S; ''Measles virus interacts with and alters signal transduction in T-cell lipid rafts.''; J Virol, 2004 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129207view01:29, 16 March 2024EweitzFix typo, fix hyphenation, tailor node dimension
127187view22:09, 9 August 2023Khanspersupdated phosphosites
123414view11:14, 25 July 2022EgonwMade four pathways clickable
120771view00:58, 4 January 2022KhanspersModified description
120770view00:57, 4 January 2022Khanspersadded xrefs and changed legend to graphical objects
119263view07:48, 23 June 2021FinterlyAdded KEGG and DOI Biopax Info
118935view22:25, 4 June 2021EweitzOntology Term : 'epithelial cell' added !
118934view22:24, 4 June 2021EweitzOntology Term : 'lymphocyte' added !
118933view22:24, 4 June 2021EweitzOntology Term : 'dendritic cell' added !
118929view16:39, 4 June 2021Finterlyspelling parenstsymbol corrected to parentsymbol in state comments
107450view17:17, 9 October 2019Khanspersupdated content
107449view00:42, 9 October 2019Khanspersupdate DC info
107448view00:19, 9 October 2019KhanspersAdded lit refs for T-cell content, updated content
107445view19:47, 8 October 2019Khanspersupdated details for T cell
107444view18:42, 8 October 2019Khanspersadded KEGG reference
107443view18:41, 8 October 2019KhanspersModified description
107442view18:40, 8 October 2019Khanspersfixed interactions
105224view19:32, 22 July 2019KhanspersAdded interaction between dendritic cell and infected cell
105211view17:12, 20 July 2019Khanspersadded peripheral blood lymphocyte
105210view16:46, 20 July 2019Khansperswork in progress
105206view00:29, 20 July 2019Khanspersupdated NFKb activation
105205view00:12, 20 July 2019Khanspersupdated legend
104951view18:59, 26 June 2019KhanspersOntology Term : 'signaling pathway pertinent to immunity' added !
104950view18:57, 26 June 2019KhanspersOntology Term : 'viral infectious disease' added !
104949view18:57, 26 June 2019KhanspersOntology Term : 'measles' added !
104946view17:29, 26 June 2019KhanspersModified description
104681view22:57, 10 June 2019Khanspersreorganization
104680view22:15, 10 June 2019Khanspersreorganization in progress
104679view21:39, 10 June 2019KhanspersModified title
104678view21:39, 10 June 2019Khanspersadded nectin-4
104667view08:37, 8 June 2019EgonwReplaced secondary ChEBI IDs with primary IDs.
104647view19:04, 7 June 2019Khanspersupdated pathway
104646view19:03, 7 June 2019KhanspersModified title
104638view06:57, 7 June 2019EgonwReplaced a secondary ChEBI ID with primary ID.
104628view23:20, 6 June 2019KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
?GeneProduct
ADARGeneProductENSG00000160710 (Ensembl)
APAF1GeneProductENSG00000120868 (Ensembl)
BADGeneProductENSG00000002330 (Ensembl)
BAK1GeneProductENSG00000030110 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BBC3GeneProductENSG00000105327 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BCL2L1GeneProductENSG00000171552 (Ensembl)
BIDGeneProductENSG00000015475 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CGeneProductBAB60863.1 (NCBI Protein)
CBLBGeneProductENSG00000114423 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CCND2GeneProductENSG00000118971 (Ensembl)
CCND3GeneProductENSG00000112576 (Ensembl)
CCNE1GeneProductENSG00000105173 (Ensembl)
CCNE2GeneProductENSG00000175305 (Ensembl)
CD209GeneProductENSG00000090659 (Ensembl)
CD28GeneProductENSG00000178562 (Ensembl)
CD3DGeneProductENSG00000167286 (Ensembl)
CD3EGeneProductENSG00000198851 (Ensembl)
CD3GGeneProductENSG00000160654 (Ensembl)
CD46GeneProductENSG00000117335 (Ensembl)
CDK2GeneProductENSG00000123374 (Ensembl)
CDK4GeneProductENSG00000135446 (Ensembl)
CDK6GeneProductENSG00000105810 (Ensembl)
CDKN1BGeneProductENSG00000111276 (Ensembl)
CHUKGeneProduct1147 (Entrez Gene) Original kegg element: gene;42;hsa:1147
CHUKGeneProductENSG00000213341 (Ensembl)
CLEC4MGeneProductENSG00000104938 (Ensembl)
CSNK2A1GeneProductENSG00000101266 (Ensembl)
CSNK2A2GeneProductENSG00000070770 (Ensembl)
CSNK2A3GeneProductENSG00000254598 (Ensembl)
CSNK2BGeneProductENSG00000204435 (Ensembl)
CYCSGeneProductENSG00000172115 (Ensembl)
Cell CyclePathwayWP179 (WikiPathways)
DDX58GeneProductENSG00000107201 (Ensembl)
EIF2AK1GeneProductENSG00000086232 (Ensembl)
EIF2AK2GeneProductENSG00000055332 (Ensembl)
EIF2AK3GeneProductENSG00000172071 (Ensembl)
EIF2AK4GeneProductENSG00000128829 (Ensembl)
EIF2S1GeneProductENSG00000134001 (Ensembl)
EIF3HGeneProductENSG00000147677 (Ensembl)
FGeneProductAAB26145.1 (NCBI Protein)
FADDGeneProductENSG00000168040 (Ensembl)
FASGeneProductENSG00000026103 (Ensembl)
FASLGGeneProductENSG00000117560 (Ensembl)
FCGR2BGeneProductENSG00000072694 (Ensembl)
FOSGeneProduct2353 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
HGeneProductAAB26146.1 (NCBI Protein)
HSPA1AGeneProductENSG00000204389 (Ensembl)
HSPA1BGeneProductENSG00000204388 (Ensembl)
HSPA1LGeneProductENSG00000204390 (Ensembl)
HSPA2GeneProductENSG00000126803 (Ensembl)
HSPA6GeneProductENSG00000173110 (Ensembl)
HSPA8GeneProductENSG00000109971 (Ensembl)
IFIH1GeneProductENSG00000115267 (Ensembl)
IFNA10GeneProductENSG00000186803 (Ensembl)
IFNA13GeneProductENSG00000233816 (Ensembl)
IFNA14GeneProductENSG00000228083 (Ensembl)
IFNA16GeneProductENSG00000147885 (Ensembl)
IFNA17GeneProductENSG00000234829 (Ensembl)
IFNA1GeneProductENSG00000197919 (Ensembl)
IFNA21GeneProductENSG00000137080 (Ensembl)
IFNA2GeneProductENSG00000188379 (Ensembl)
IFNA4GeneProductENSG00000236637 (Ensembl)
IFNA5GeneProductENSG00000147873 (Ensembl)
IFNA6GeneProductENSG00000120235 (Ensembl)
IFNA7GeneProductENSG00000214042 (Ensembl)
IFNA8GeneProductENSG00000120242 (Ensembl)
IFNAR1GeneProductENSG00000142166 (Ensembl)
IFNAR2GeneProductENSG00000159110 (Ensembl)
IFNB1GeneProductENSG00000171855 (Ensembl)
IKBKBGeneProduct3551 (Entrez Gene) Original kegg element: gene;36;hsa:3551
IKBKBGeneProductENSG00000104365 (Ensembl)
IKBKEGeneProduct9641 (Entrez Gene) Original kegg element: gene;54;hsa:9641
IKBKGGeneProduct8517 (Entrez Gene) Original kegg element: gene;85;hsa:8517
IKBKGGeneProductENSG00000269335 (Ensembl)
IL12AGeneProductENSG00000168811 (Ensembl)
IL12BGeneProductENSG00000113302 (Ensembl)
IL1AGeneProductENSG00000115008 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL2GeneProductENSG00000109471 (Ensembl)
IL2RAGeneProductENSG00000134460 (Ensembl)
IL2RBGeneProductENSG00000100385 (Ensembl)
IL2RGGeneProductENSG00000147168 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
IRAK1GeneProduct3654 (Entrez Gene) Original kegg element: gene;41;hsa:3654
IRAK4GeneProduct51135 (Entrez Gene) Original kegg element: gene;86;hsa:51135
IRF3GeneProductENSG00000126456 (Ensembl)
IRF7GeneProductENSG00000185507 (Ensembl)
IRF9GeneProductENSG00000213928 (Ensembl)
JAK1GeneProductENSG00000162434 (Ensembl)
JAK3GeneProductENSG00000105639 (Ensembl)
JUNGeneProduct3725 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
LGeneProduct1489802 (Entrez Gene)
LPSMetaboliteCHEBI:16412 (ChEBI)
MGeneProduct
MAP3K7GeneProduct6885 (Entrez Gene) Original kegg element: gene;37;hsa:6885
MAPK10GeneProduct5602 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAPK8GeneProduct5599 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAPK9GeneProduct5601 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
MAVSGeneProductENSG00000088888 (Ensembl)
MSNGeneProductENSG00000147065 (Ensembl)
MX1GeneProductENSG00000157601 (Ensembl)
MYD88GeneProduct4615 (Entrez Gene) Original kegg element: gene;8;hsa:4615
NGeneProduct1489804 (Entrez Gene)
NGeneProductBAX00474.1 (NCBI Protein)
NECTIN4GeneProductENSG00000143217 (Ensembl)
NFKB1GeneProduct4790 (Entrez Gene)
NFKB2GeneProduct4791 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
NFKBIAGeneProduct4792 (Entrez Gene) Original kegg element: gene;64;hsa:4792
NFKBIAGeneProductENSG00000100906 (Ensembl)
NFKBIBGeneProductENSG00000104825 (Ensembl)
OAS1GeneProductENSG00000089127 (Ensembl)
OAS2GeneProductENSG00000111335 (Ensembl)
OAS3GeneProductENSG00000111331 (Ensembl)
PGeneProduct1489805 (Entrez Gene)
PGeneProductBAB60859.1 (NCBI Protein)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CDGeneProductENSG00000171608 (Ensembl)
PIK3R1GeneProductENSG00000145675 (Ensembl)
PIK3R2GeneProductENSG00000105647 (Ensembl)
PIK3R3GeneProductENSG00000117461 (Ensembl)
RAB9AGeneProductENSG00000123595 (Ensembl)
RAB9BGeneProductENSG00000123570 (Ensembl)
RACK1GeneProductENSG00000204628 (Ensembl)
RCHY1GeneProductENSG00000163743 (Ensembl)
RELAGeneProduct5970 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
RELAGeneProductENSG00000173039 (Ensembl)
RIG-1-like receptor signaling pathwayPathway
SLAMF1GeneProductENSG00000117090 (Ensembl)
STAT1GeneProductENSG00000115415 (Ensembl)
STAT2GeneProductENSG00000170581 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
STAT5AGeneProductENSG00000126561 (Ensembl)
STAT5BGeneProductENSG00000173757 (Ensembl)
TAB2GeneProduct23118 (Entrez Gene) Original kegg element: gene;61;hsa:23118
TBK1GeneProduct29110 (Entrez Gene) Original kegg element: gene;52;hsa:29110
TLR2GeneProductENSG00000137462 (Ensembl)
TLR4GeneProductENSG00000136869 (Ensembl)
TLR7GeneProductENSG00000196664 (Ensembl)
TLR9GeneProductENSG00000239732 (Ensembl)
TNFAIP3GeneProductENSG00000118503 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
TP73GeneProductENSG00000078900 (Ensembl)
TRADDGeneProductENSG00000102871 (Ensembl)
TRAF3GeneProductENSG00000131323 (Ensembl)
TRAF6GeneProduct7189 (Entrez Gene) Original kegg element: gene;53;hsa:7189
TYK2GeneProductENSG00000105397 (Ensembl)
Ubiquitin-mediated proteolysisPathwayWP183 (WikiPathways)
Ubiquitin-mediated proteolysisPathwayWP183 (WikiPathways)
VGeneProductAB481088.1 (NCBI Protein)
p53 siganling pathwayPathwayWP1742 (WikiPathways)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4630"
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