22q11.2 copy number variation syndrome (Homo sapiens)

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5420464685669431, 864169355216, 79292517, 75358341968918050304765, 8716, 8153, 61, 67, 7680495LCR22D21,500,000Increased expressionin gastric and othercancersNeurite outgrowthunknownfunctionTranslocationexact function unknownUbiquitinated proteinunknown functionpossible candidate forretinitis pigmentosaAmino acid transporter activity questionedcell division cycle regulatory proteincytoskeleton organizationneurotransmitter releasechr22:21,465,672unknown functionno informationavailable, yetunclear functionpossibly involved in mitochondria functionneurodevelopmentExocytosisunknown functionubiquitin carboxyl-terminal hydrolase activityCandidate gene foroculo-auriculo-vertebral spectrum (OAVS) asymmetryLegendSchizophrenia risk gene1858215978LINC01311FAM230EADP(3−)CLDN3C22orf39RBX1LysineSMPD4P1P2RX6PCellular proliferationArginineTight junctionNPRL3SNORA77BKRT18P62MAGCLDN1DGCR11DEPDC5PLK1PAK4RCC1Cell junction organizationRNU6-225PComplement and coagulation cascadesCUL3Purinergic signalingRN7SL168PPOM121L4PRNY1P91-phosphatidyl-1D-myo-inositol 4-phosphate(3−)CDH15TMEM191AOrnithineRELNNPRL2DGCR91-phosphatidyl-1D-myo-inositol(1−)TUBA3GPBCRP539S mitochondrial large ribosomal subunitSLC9A3P2tRNA modification in the nucleus and cytosolSREBF2RN7SL812PABHD17AP4MALT1BCRP2HDAC3GATOR1 complexHeparinATP(4−)Mitochondrial translationSEPTIN8SyntaxinActivation of gene expressionby SREBF (SREBP)Nuclear transportTNPO1POLR2ALINC01637TUBA3FPRTN4POM121L7PSEPTIN11HIST1H4AIGLL4PDermatan sulfateLINC00895DGCR10FAM230GATPSREBF1CA15P1PRKNApoptosisG protein signalingpathwaysXPO1RANGAP1RANCCDC74BP1mRNA ProcessingTP53KRT18P5NCOR1p75 NTR receptor-mediated signalingBCR(KLHL22) E3 ubiquitin ligase complexTSSK1ARORCARNTLReelin signaling pathwayBCL2135631290923Gene ProductMetabolitemiRnaReward-mediating mesocorticolimbicpathwaysMIM-stimulation of an enzyme or a gene leading to its activation or expressionData node for a micro RNA or another RNA geneData node for a pathwayMIM-inhibition of a compound's function or a processMIM-catalysis of a compound by an enzymePathwayComplexMIM-gap of knowledge on the exact nature of the interactionMIM-transcription-translation of a geneData node for a metaboliteDashed line indicates unclear mechanismof interaction/unclear intermediatesData node for a gene or its productMIM-conversion of a compound to anotherMIM-binding of a compound to anotherSynaptic transmissionat thalamocortical glutamatergic projectionshsa-miR-9-5pInsulin signalingVWFDopamine metabolismBlood clotting cascadeHeart developmentGP1BBGP1BANeurotransmitter clearanceDRD2GP5LINC00037GP9Translocation of SLC2A4 to the plasma membrane 45708433368284363749436472384562143432356101448568, 2222, 7748, 51, 603434343PPCentromeredegradation of ubiquitinfusion proteinsnucleosome assemblyduring sperm nucleus decondensationApoptosisthrough caspase activationNeurite outgrowthin neural precursorcellsmitochondrial redoxhomeostasis MitochondrionDNA unwinding during replication elongation cell cycle-dependenthistone genetranscriptionMesenchymeVesicle fusion at the endoplasmic reticulum or Golgi membranesAsymmetric remodelling of PAASecond heart fieldAxonal growth(Premature) differentiation of SHF cellsNeuronal inhibitionIncreased RA signallingIntracellular signalingSERPIND1GLUD1CCDC188hsa-mir-4761ARVCFRAF1MED15ALDH4A1KLHL22LZTR1UFD12-oxoglutaric acidTHAP7SLC7A4DGCR6LCitrateL-Glutamic gamma-semialdehydeLRRC74BOATTSSK2RAF1hsa-mir-1286HIRIP3ProlineHAND2SHOC2RTN4RCDC45SLC2A4SEPTIN5RAS/MAPK signal transductionTANGO2DGCR2hsa-miR-3618LINC00896Urea cycleGSC288CLDN5GNB1LOrnithineAIFM3TXNRD2RANBP1GlutamineRTL10ZNF74PPP1CBP2RX6ESS2GlutamateCBX5TCA cycleTRMT2API4KAASF1AMRPL4039hsa-mir-6816USP41RiluzoleCLTCL1HIRAhsa-mir-1306PAX3TSKShsa-mir-649FGF10SLC25A12CRKL1-pyrroline-5-carboxylateSCARF2retinalEMC10NormetanephrineHomovanillic acidRetinoic acidSRFDROSHAFOXA2hsa-miR-194-1PRODHFGF8CYP26B14-oxo-Retinoic acidCOMTCHRDFOXC1CRKLSHHNorepinephrineCYP26A1DopaminePITX2ZDHHC8FGF8FGFR2DGCR8DL-MetanephrineEpinephrineTBX1hsa-miR-185CYP26C1FOXC2Retinoic acidFGFR14-hydroxyretinoic acidhsa-miR-363NKX2-5hsa-miR-150ALDH1A2DOPAC3-MethoxytyramineSNAP29FGFR2FGFR1CDC4242DGCR857hsa-miR-18511EctodermcNCC patterningNeurogenesis and neural differentiationHES1HES1GBX2Notch signalling(Premature) muscular differentiation GP1BB77311RAF1PCitrateTCA cycleGP1b-IX-V activation signaling1212ACTA2ACTC1DopamineFOXA2FOXC1FOXC2TBX134DGCR5EGFRchr22:18,912,231TSKS92BCRP7Data node for a pseudo gene24, 52RORCCircadian expressioncycleSEPTIN52915, 74USEPTIN5U40, 44RANBP1KPNB126POLR2APhosphorylated proteinKLHL22PLK1UDEPDC5DEPDC5U30P2RX6UOrnithineArginineLysine68682020LCR22C21,000,000LCR22B20,500,000LCR22A<19,000,00035351


Description

The 22q11.2 deletion syndrome can result in the loss of up to 46 protein-coding genes, which have wide-spread effects on human development. The loss of TBX1 is thought to be responsible for a large proportion of the 22q11.2DS phenotype, due its role in the development of the heart, thymus, thyroid, parathyroids and more.

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History

View all...
CompareRevisionActionTimeUserComment
128796view01:48, 22 February 2024EweitzStandardize case
120007view13:13, 11 October 2021FehrhartReverted to version '11:20, 17 September 2021' by Fehrhart
120003view15:30, 9 October 2021MlatorreModified title
119921view11:20, 17 September 2021FehrhartUpdate HIST1H4A for H4C1
116172view14:56, 15 April 2021Fehrhartadded literature reference
115785view07:45, 12 March 2021Fehrhartgraphical update
115783view16:08, 11 March 2021Fehrhartupdate in progress
115782view15:48, 11 March 2021Fehrhartupdate in progress
115781view15:46, 11 March 2021Fehrhartupdated to GRCH37
113893view11:05, 7 December 2020Fehrhartcorrected a typo
113890view18:26, 6 December 2020EgonwAdded the missing Complex Portal data source
113889view18:23, 6 December 2020EgonwUpdated the HMDB identifiers.
113876view15:55, 3 December 2020Fehrhartadded breakpoints LCR22A-D
113874view11:33, 3 December 2020Fehrhartmajor update done
113873view10:57, 3 December 2020Fehrhartupdate in progress
113872view10:48, 3 December 2020Fehrhartupdate in progress
113840view16:41, 30 November 2020Fehrhartupdate in progress
113839view16:31, 30 November 2020Fehrhartupdate in progress
113816view15:39, 27 November 2020Fehrhartupdate in progress
113815view15:10, 27 November 2020Fehrhartupdate in progress
113653view20:50, 9 November 2020FehrhartUpdate in progress
113640view15:06, 9 November 2020Fehrhartupdate in progress
113597view10:08, 4 November 2020Fehrhartupdate
113591view08:17, 4 November 2020Fehrhartupdate
113590view08:01, 4 November 2020Fehrhartupdate
113589view14:24, 3 November 2020Fehrhartupdate legend
113588view13:55, 3 November 2020FehrhartUpdate
112047view14:35, 17 September 2020FehrhartModified title
111568view12:43, 25 August 2020Fehrhartupdate in progress
111567view11:56, 25 August 2020Fehrhartupdate in progress
111564view11:16, 25 August 2020Fehrhartupdate in progress
111262view16:20, 27 July 2020FehrhartUndergoing reconstruction and completion of deleted gene list
109347view12:55, 16 March 2020L DupuisConnected unconnected line
109316view10:45, 11 March 2020FehrhartAdded DGCR5 path, aligned genes with red line.
107179view14:26, 17 September 2019MaintBotChEBI identifier normalization
106807view13:28, 17 September 2019MaintBotHMDB identifier normalization
105133view06:22, 10 July 2019Fehrhartfixed unconnected lines and SHH part of pathway
105073view17:20, 4 July 2019Victoravrfixed interactions
105072view12:57, 4 July 2019VictoravrAdded CLTC1 pathways
105049view21:44, 2 July 2019Victoravr2 added pathways for COMT
105048view20:54, 2 July 2019VictoravrAdded legend and fixed interactions
105027view16:42, 30 June 2019VictoravrDGCR8 mediated DRD2 upregulation added
105025view10:40, 29 June 2019EgonwReplaced secondary ChEBI identifiers with a primary identifiers.
104987view21:55, 27 June 2019Victoravradded pathway
104984view19:56, 27 June 2019VictoravrAdded downstream genes
104957view12:03, 27 June 2019VictoravrGP1BB downstream added
104955view10:21, 27 June 2019VictoravrAdding of gene functional descriptions
104952view07:25, 27 June 2019Fehrhartwork in progress
104941view11:53, 26 June 2019VictoravrOntology Term : 'neurological disorder pathway' added !
104940view11:50, 26 June 2019VictoravrOntology Term : 'disease pathway' added !

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1-phosphatidyl-1D-myo-inositol 4-phosphate(3−)MetaboliteCHEBI:58178 (ChEBI)
1-phosphatidyl-1D-myo-inositol(1−)MetaboliteCHEBI:57880 (ChEBI)
1-pyrroline-5-carboxylateMetaboliteCHEBI:15893 (ChEBI)
2-oxoglutaric acidMetaboliteCHEBI:30915 (ChEBI)
3-MethoxytyramineMetaboliteCHEBI:1582 (ChEBI)
39S mitochondrial large ribosomal subunitComplexCPX-5226 (Complex Portal)
4-hydroxyretinoic acidMetaboliteCHEBI:63795 (ChEBI)
4-oxo-Retinoic acidMetaboliteHMDB0006285 (HMDB)
ABHD17AP4 GeneProductENSG00000229107 (Ensembl)
ACTA2GeneProductENSG00000107796 (Ensembl)
ACTC1GeneProductENSG00000159251 (Ensembl)
ADP(3−)MetaboliteCHEBI:456216 (ChEBI)
AIFM3GeneProductENSG00000183773 (Ensembl)
ALDH1A2GeneProductENSG00000128918 (Ensembl)
ALDH4A1GeneProductENSG00000159423 (Ensembl)
ARNTLGeneProductENSG00000133794 (Ensembl)
ARVCFGeneProductENSG00000099889 (Ensembl)
ASF1AGeneProductENSG00000111875 (Ensembl)
ATP(4−)MetaboliteCHEBI:30616 (ChEBI)
ATPMetabolite15422 (ChEBI)
Activation of gene expression by SREBF (SREBP)PathwayWP2706 (WikiPathways)
ApoptosisPathwayWP254 (WikiPathways)
ArginineMetaboliteCHEBI:29016 (ChEBI)
BCL2GeneProductENSG00000171791 (Ensembl)
BCR(KLHL22) E3 ubiquitin ligase complexComplex
BCRP2GeneProductENSG00000169668 (Ensembl)
BCRP5GeneProductENSG00000235062 (Ensembl)
BCRP7GeneProductENSG00000215544 (Ensembl)
Blood clotting cascadePathwayWP272 (WikiPathways)
C22orf39 GeneProductENSG00000242259 (Ensembl)
CA15P1GeneProductENSG00000241527 (Ensembl)
CBX5GeneProductENSG00000094916 (Ensembl)
CCDC188GeneProductENSG00000234409 (Ensembl)
CCDC74BP1 GeneProductENSG00000250261 (Ensembl)
CDC42GeneProductENSG00000070831 (Ensembl) ONLY isoform 2, which is brain-specific; CDC42PALM
CDC45GeneProductENSG00000093009 (Ensembl)
CDH15GeneProductENSG00000129910 (Ensembl)
CHRDGeneProductENSG00000090539 (Ensembl)
CLDN1GeneProductENSG00000163347 (Ensembl)
CLDN3GeneProductENSG00000165215 (Ensembl)
CLDN5GeneProductENSG00000184113 (Ensembl)
CLTCL1GeneProductENSG00000070371 (Ensembl)
COMTGeneProductENSG00000093010 (Ensembl)
CRKLGeneProductENSG00000099942 (Ensembl)
CUL3GeneProductENSG00000036257 (Ensembl)
CYP26A1GeneProductENSG00000095596 (Ensembl)
CYP26B1GeneProductENSG00000003137 (Ensembl)
CYP26C1GeneProductENSG00000187553 (Ensembl)
Cell junction organizationPathwayWP1793 (WikiPathways)
Cellular proliferationPathwayQ189101 (Wikidata)
CitrateMetaboliteCHEBI:133748 (ChEBI) Cytplasm citrate
Complement and coagulation cascadesPathwayWP558 (WikiPathways)
DEPDC5GeneProductENSG00000100150 (Ensembl)
DGCR10GeneProductENSG00000273164 (Ensembl)
DGCR11GeneProductENSG00000273311 (Ensembl)
DGCR2GeneProductENSG00000070413 (Ensembl)
DGCR5GeneProductENSG00000237517 (Ensembl)
DGCR6LGeneProductENSG00000128185 (Ensembl)
DGCR8GeneProductENSG00000128191 (Ensembl)
DGCR9GeneProductENSG00000273032 (Ensembl)
DL-MetanephrineMetaboliteCHEBI:89633 (ChEBI)
DOPACMetaboliteCHEBI:41941 (ChEBI)
DRD2GeneProductENSG00000149295 (Ensembl)
DROSHAGeneProductENSG00000113360 (Ensembl)
Dermatan sulfateMetaboliteCHEMBL1909290 (ChEMBL compound)
Dopamine metabolismPathwayWP2436 (WikiPathways)
DopamineMetaboliteCHEBI:18243 (ChEBI)
EGFRGeneProductENSG00000146648 (Ensembl)
EMC10GeneProductENSG00000161671 (Ensembl)
ESS2GeneProductENSG00000100056 (Ensembl) DGCR14
EpinephrineMetaboliteCHEBI:33568 (ChEBI)
FAM230EGeneProductENSG00000182824 (Ensembl)
FAM230G GeneProductENSG00000188280 (Ensembl)
FGF10GeneProductENSG00000070193 (Ensembl)
FGF8GeneProductENSG00000107831 (Ensembl)
FGFR1GeneProductENSG00000077782 (Ensembl)
FGFR2GeneProductENSG00000066468 (Ensembl)
FOXA2GeneProductENSG00000125798 (Ensembl)
FOXC1GeneProductENSG00000054598 (Ensembl)
FOXC2GeneProductENSG00000176692 (Ensembl)
G protein signaling pathwaysPathwayWP35 (WikiPathways)
GATOR1 complexComplexCPX-6226 (Complex Portal)
GBX2GeneProductENSG00000168505 (Ensembl)
GLUD1GeneProductENSG00000148672 (Ensembl)
GNB1LGeneProductENSG00000185838 (Ensembl)
GP1BAGeneProductENSG00000185245 (Ensembl)
GP1BBGeneProductENSG00000203618 (Ensembl)
  • Involved in Macrothrombocytopenia development
  • Responsible for Bernard-Soulier syndrome
GP1b-IX-V activation signalingPathwayWP1823 (WikiPathways)
GP5GeneProductENSG00000178732 (Ensembl)
GP9GeneProductENSG00000169704 (Ensembl)
GSC2GeneProductENSG00000063515 (Ensembl) DNA sequence-specific recognition of sites bound by the Drosophila anterior morphogen, Bicoid
GlutamateMetaboliteCHEBI:14321 (ChEBI)
GlutamineMetaboliteCHEBI:28300 (ChEBI)
HAND2GeneProductENSG00000164107 (Ensembl)
HDAC3GeneProductENSG00000171720 (Ensembl)
HES1GeneProductENSG00000114315 (Ensembl)
HIRAGeneProductENSG00000100084 (Ensembl)
HIRIP3GeneProductENSG00000149929 (Ensembl)
HIST1H4AGeneProductENSG00000278637 (Ensembl)
Heart developmentPathwayWP1591 (WikiPathways)
HeparinMetabolite22833565 (PubChem-compound)
Homovanillic acidMetaboliteCHEBI:545959 (ChEBI)
IGLL4P GeneProductENSG00000276427 (Ensembl)
Insulin signalingPathwayWP481 (WikiPathways)
KLHL22GeneProductENSG00000099910 (Ensembl)
KPNB1GeneProductENSG00000108424 (Ensembl)
KRT18P5 GeneProductENSG00000236670 (Ensembl)
KRT18P62 GeneProductENSG00000233471 (Ensembl)
L-Glutamic gamma-semialdehydeMetaboliteHMDB0002104 (HMDB)
LINC00037RnaENSG00000237517 (Ensembl)
LINC00895 GeneProductENSG00000281548 (Ensembl)
LINC00896GeneProductENSG00000236499 (Ensembl)
LINC01311GeneProductENSG00000260924 (Ensembl)
LINC01637GeneProductENSG00000237476 (Ensembl)
LRRC74BGeneProductENSG00000187905 (Ensembl)
LZTR1GeneProductENSG00000099949 (Ensembl)
LysineMetaboliteCHEBI:25094 (ChEBI)
MAGGeneProductENSG00000105695 (Ensembl) p75
MALT1GeneProductENSG00000172175 (Ensembl)
MED15GeneProductENSG00000099917 (Ensembl)
MRPL40GeneProductENSG00000185608 (Ensembl)
Mitochondrial translationPathwayWP3310 (WikiPathways)
NCOR1GeneProductENSG00000141027 (Ensembl)
NKX2-5GeneProductENSG00000183072 (Ensembl)
NPRL2GeneProductENSG00000114388 (Ensembl)
NPRL3GeneProductENSG00000103148 (Ensembl)
Neurotransmitter clearancePathwayWP1870 (WikiPathways)
NorepinephrineMetaboliteCHEBI:18357 (ChEBI)
NormetanephrineMetaboliteCHEBI:89951 (ChEBI)
Notch signallingPathway268 (WikiPathways)
Nuclear transportPathwayQ994741 (Wikidata)
OATGeneProductENSG00000065154 (Ensembl)
OrnithineMetaboliteCHEBI:16176 (ChEBI)
OrnithineMetaboliteHMDB0000214 (HMDB)
P2RX6GeneProductENSG00000099957 (Ensembl)
P2RX6ProteinO15547 (Uniprot-TrEMBL)
P2RX6PGeneProductENSG00000206145 (Ensembl)
PAK4GeneProductENSG00000130669 (Ensembl)
PAX3GeneProductENSG00000135903 (Ensembl)
PI4KAGeneProductENSG00000241973 (Ensembl)
PITX2GeneProductENSG00000164093 (Ensembl)
PLK1GeneProductENSG00000166851 (Ensembl)
POLR2AGeneProductENSG00000181222 (Ensembl)
POM121L4PGeneProductENSG00000217261 (Ensembl)
POM121L7PGeneProductENSG00000239511 (Ensembl)
PPP1CBGeneProductENSG00000213639 (Ensembl)
PRKNGeneProductENSG00000185345 (Ensembl)
PRODHGeneProductENSG00000100033 (Ensembl)
ProlineMetaboliteCHEBI:26271 (ChEBI)
Purinergic signalingPathwayWP4900 (WikiPathways)
RAF1GeneProductENSG00000132155 (Ensembl)
RANBP1GeneProductENSG00000099901 (Ensembl)
RANGeneProductENSG00000132341 (Ensembl)
RANGAP1GeneProductENSG00000100401 (Ensembl)
RAS/MAPK signal transductionPathwayWP2735 (WikiPathways)
RBX1GeneProductENSG00000100387 (Ensembl)
RCC1GeneProductENSG00000180198 (Ensembl)
RELNGeneProductENSG00000189056 (Ensembl)
RN7SL168P GeneProductENSG00000244296 (Ensembl)
RN7SL812P GeneProductENSG00000242876 (Ensembl)
RNU6-225P GeneProductENSG00000207343 (Ensembl)
RNY1P9 GeneProductENSG00000255156 (Ensembl)
RORCGeneProductENSG00000143365 (Ensembl)
RORCProteinP51449 (Uniprot-TrEMBL)
RTL10GeneProductENSG00000215012 (Ensembl) BH3-only, Bop
RTN4GeneProductENSG00000115310 (Ensembl)
RTN4RGeneProductENSG00000040608 (Ensembl) also known as Nogo-66 Receptor (NgR) or Nogo receptor 1
Reelin signaling pathwayPathwayWP4083 (WikiPathways)
Retinoic acidMetaboliteCHEBI:6067 (ChEBI)
RiluzoleMetaboliteCHEBI:8863 (ChEBI)
SCARF2GeneProductENSG00000244486 (Ensembl)
SEPTIN11GeneProductENSG00000138758 (Ensembl)
SEPTIN5 GeneProductENSG00000184702 (Ensembl) CDCrel-1
SEPTIN8GeneProductENSG00000164402 (Ensembl) KIAA0202
SERPIND1GeneProductENSG00000099937 (Ensembl)
SHHGeneProductENSG00000164690 (Ensembl)
SHOC2GeneProductENSG00000108061 (Ensembl)
SLC25A1GeneProductENSG00000100075 (Ensembl)
  • Altered mitochondrial metabolism
  • Causative gene for Combined D-2- and L-2-hydroxyglutaric aciduria
SLC2A4GeneProductENSG00000181856 (Ensembl)
SLC7A4GeneProductENSG00000099960 (Ensembl)
SLC9A3P2 GeneProductENSG00000238125 (Ensembl)
SMPD4P1 GeneProductENSG00000223553 (Ensembl)
SNAP29GeneProductENSG00000099940 (Ensembl)
SNORA77B GeneProductENSG00000264346 (Ensembl)
SREBF1GeneProductENSG00000072310 (Ensembl)
SREBF2GeneProductENSG00000198911 (Ensembl)
SRFGeneProductENSG00000112658 (Ensembl)
SyntaxinGeneProductPF00804 (Pfam)
TANGO2GeneProductENSG00000183597 (Ensembl)
TBX1GeneProductENSG00000184058 (Ensembl)
TCA cyclePathwayWP78 (WikiPathways)
THAP7GeneProductENSG00000184436 (Ensembl)
TMEM191AGeneProductENSG00000226287 (Ensembl)
TNPO1GeneProductENSG00000083312 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
TRMT2AGeneProductENSG00000099899 (Ensembl)
TSKSGeneProductENSG00000126467 (Ensembl)
TSSK1AGeneProductENSG00000231086 (Ensembl)
TSSK2GeneProductENSG00000206203 (Ensembl)
TUBA3FPGeneProductENSG00000161149 (Ensembl)
TUBA3GPGeneProductENSG00000249680 (Ensembl)
TXNRD2GeneProductENSG00000184470 (Ensembl)
Tight junctionPathwayWP1793 (WikiPathways)
Translocation of SLC2A4 to the plasma membrane PathwayWP2777 (WikiPathways)
UFD1GeneProductENSG00000070010 (Ensembl)
USP41GeneProductENSG00000161133 (Ensembl)
Urea cyclePathwayWP497 (WikiPathways)
VWFGeneProductENSG00000110799 (Ensembl)
XPO1GeneProductENSG00000082898 (Ensembl)
ZDHHC8GeneProductENSG00000099904 (Ensembl)
ZNF74GeneProductENSG00000185252 (Ensembl)
hsa-miR-150RnaMIMAT0000451 (miRBase mature sequence)
hsa-miR-185RnaMIMAT0000455 (miRBase mature sequence)
hsa-miR-194-1RnaMIMAT0000460 (miRBase mature sequence)
hsa-miR-3618RnaMIMAT0017998 (miRBase mature sequence)
hsa-miR-363RnaMIMAT0000707 (miRBase mature sequence)
hsa-miR-9-5pRnaMIRT437986 (miRBase mature sequence) NEEDS VERIFICATION! assumption based on study finding dgcr8 deletion increases drd2 expression which is only a target to hsa-miR-9 according to mirtarbase
hsa-mir-1286RnaMIMAT0005877 (miRBase mature sequence)
hsa-mir-1306RnaMI0006443 (miRBase Sequence)
hsa-mir-4761RnaMI0017402 (miRBase Sequence)
hsa-mir-649RnaMIMAT0003319 (miRBase mature sequence)
hsa-mir-6816RnaMI0022661 (miRBase Sequence)
mRNA ProcessingPathwayWP411 (WikiPathways)
p75 NTR receptor-mediated signalingPathwayWP4443 (WikiPathways)
retinalMetaboliteCHEBI:15035 (ChEBI)
tRNA modification in the nucleus and cytosolPathwayWP3561 (WikiPathways)

Annotated Interactions

SourceTargetTypeDatabase referenceComment
1-phosphatidyl-1D-myo-inositol(1−)1-phosphatidyl-1D-myo-inositol 4-phosphate(3−)mim-conversion19877 (Rhea)
ATP(4−)ADP(3−)mim-conversion19877 (Rhea)
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4657"
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