Peroxiredoxin 2 induced ovarian failure (Mus musculus)

Description

This pathway summarizes the influence of reactive oxygen species on ovarian aging, ovarian failure and therefore female infertility.

View approved pathways at the new wikipathways.org.

Park SJ, Kim JH, Lee DG, Kim JM, Lee DS; ''Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice.''; Free Radic Biol Med, 2018 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
134351	view	05:38, 21 July 2024	Egonw	Removed a template comment
110293	view	14:20, 2 May 2020	Egonw	Replaced secondary ChEBI identifiers with a primary identifiers.
110230	view	14:26, 27 April 2020	Egonw	Updated the data source.
110070	view	08:45, 16 April 2020	Fehrhart	Ontology Term : 'c-Jun N-terminal kinases MAPK signaling pathway' added !
110069	view	08:45, 16 April 2020	Fehrhart	Added reference and some graphical adjustments
110068	view	08:43, 16 April 2020	Fehrhart	Modified description
109438	view	12:54, 17 March 2020	Fehrhart	Ontology Term : 'ovarian dysfunction' added !
109437	view	12:54, 17 March 2020	Fehrhart	Ontology Term : 'signaling pathway' added !
109250	view	11:56, 2 March 2020	Laurent	Modified title
109233	view	12:10, 1 March 2020	Bas Lahaije	New pathway

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Name	Type	Database reference	Comment
3Beta-HSD	Protein	E9PXG7 (Uniprot-TrEMBL)
Bax	GeneProduct	ENSMUSG00000003873 (Ensembl)
CYP11A1	Protein	Q9QZ82 (Uniprot-TrEMBL)	Mitochondrial
Caspase-3	Protein	A0A1B0GRX1 (Uniprot-TrEMBL)
Cytochrome c	Protein	P62897 (Uniprot-TrEMBL)	Somatic
Estradiol-17beta	Metabolite	CHEBI:16469 (ChEBI)
JNK	Protein	ENSMUSP00000023291 (Ensembl)
PARP	Metabolite	CHEBI:62913 (ChEBI)
Peroxiredoxin-2	Protein	Q61171 (Uniprot-TrEMBL)
Progesterone	Metabolite	CHEBI:17026 (ChEBI)
Reactive oxygen species	Metabolite	CHEBI:26523 (ChEBI)
StAR	Protein	P51557 (Uniprot-TrEMBL)	Mitichondrial

No annotated interactions