Endothelin pathway (Homo sapiens)
From WikiPathways
Description
Endothelin is a strong peptide well known for its vasoconstriction activities. It is known for regulating extensive physiological and pathophysiological activities with beneficial and detrimental roles in mammals.To develop this network map of endothelin mediated signalling pathway, We searched term retrieved 2,800 papers in Pubmed were used for initial screening. Of these, 640 research articles were screened for endothelin mediated reactions and selected for annotation. Out of these, 334 articles had information which are compatible to endothelin mediated signalling were selected for further curation. The manual curation of selected articles documented 90 activation / inhibition events, 98 PTM or catalysis events, 56molecular associations, 239 gene regulation events, 145 types of protein expression and 27 protein translocation events.
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Bibliography
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- Tokudome T, Horio T, Soeki T, Mori K, Kishimoto I, Suga S, Yoshihara F, Kawano Y, Kohno M, Kangawa K; ''Inhibitory effect of C-type natriuretic peptide (CNP) on cultured cardiac myocyte hypertrophy: interference between CNP and endothelin-1 signaling pathways.''; Endocrinology, 2004 PubMed Europe PMC Scholia
- Goto A, Sumiyama K, Kamioka Y, Nakasyo E, Ito K, Iwasaki M, Enomoto H, Matsuda M; ''GDNF and endothelin 3 regulate migration of enteric neural crest-derived cells via protein kinase A and Rac1.''; J Neurosci, 2013 PubMed Europe PMC Scholia
- Di Nunzio AS, Jaureguiberry MS, Rodano V, Bianciotti LG, Vatta MS; ''Endothelin-1 and -3 diminish neuronal NE release through an NO mechanism in rat anterior hypothalamus.''; Am J Physiol Regul Integr Comp Physiol, 2002 PubMed Europe PMC Scholia
- Chahdi A, Sorokin A; ''The role of beta(1)Pix/caveolin-1 interaction in endothelin signaling through Galpha subunits.''; Biochem Biophys Res Commun, 2010 PubMed Europe PMC Scholia
- Hinsley EE, Hunt S, Hunter KD, Whawell SA, Lambert DW; ''Endothelin-1 stimulates motility of head and neck squamous carcinoma cells by promoting stromal-epithelial interactions.''; Int J Cancer, 2012 PubMed Europe PMC Scholia
- Yamboliev IA, Gerthoffer WT; ''Modulatory role of ERK MAPK-caldesmon pathway in PDGF-stimulated migration of cultured pulmonary artery SMCs.''; Am J Physiol Cell Physiol, 2001 PubMed Europe PMC Scholia
- Wu MH, Huang CY, Lin JA, Wang SW, Peng CY, Cheng HC, Tang CH; ''Endothelin-1 promotes vascular endothelial growth factor-dependent angiogenesis in human chondrosarcoma cells.''; Oncogene, 2014 PubMed Europe PMC Scholia
- Tang B, Li Y, Nagaraj C, Morty RE, Gabor S, Stacher E, Voswinckel R, Weissmann N, Leithner K, Olschewski H, Olschewski A; ''Endothelin-1 inhibits background two-pore domain channel TASK-1 in primary human pulmonary artery smooth muscle cells.''; Am J Respir Cell Mol Biol, 2009 PubMed Europe PMC Scholia
- Glenn DJ, Rahmutula D, Nishimoto M, Liang F, Gardner DG; ''Atrial natriuretic peptide suppresses endothelin gene expression and proliferation in cardiac fibroblasts through a GATA4-dependent mechanism.''; Cardiovasc Res, 2009 PubMed Europe PMC Scholia
- Hunter JC, Zeidan A, Javadov S, Kilic A, Rajapurohitam V, Karmazyn M; ''Nitric oxide inhibits endothelin-1-induced neonatal cardiomyocyte hypertrophy via a RhoA-ROCK-dependent pathway.''; J Mol Cell Cardiol, 2009 PubMed Europe PMC Scholia
- Chahdi A, Sorokin A; ''Endothelin-1 couples betaPix to p66Shc: role of betaPix in cell proliferation through FOXO3a phosphorylation and p27kip1 down-regulation independently of Akt.''; Mol Biol Cell, 2008 PubMed Europe PMC Scholia
- Kakita T, Hasegawa K, Iwai-Kanai E, Adachi S, Morimoto T, Wada H, Kawamura T, Yanazume T, Sasayama S; ''Calcineurin pathway is required for endothelin-1-mediated protection against oxidant stress-induced apoptosis in cardiac myocytes.''; Circ Res, 2001 PubMed Europe PMC Scholia
- Tocci P, Caprara V, Cianfrocca R, Sestito R, Di Castro V, Bagnato A, Rosano L; ''Endothelin-1/endothelin A receptor axis activates RhoA GTPase in epithelial ovarian cancer.''; Life Sci, 2016 PubMed Europe PMC Scholia
- Seccia TM, Caroccia B, Gioco F, Piazza M, Buccella V, Guidolin D, Guerzoni E, Montini B, Petrelli L, Pagnin E, Ravarotto V, Belloni AS, Calo LA, Rossi GP; ''Endothelin-1 Drives Epithelial-Mesenchymal Transition in Hypertensive Nephroangiosclerosis.''; J Am Heart Assoc, 2016 PubMed Europe PMC Scholia
- Cazaubon S, Chaverot N, Romero IA, Girault JA, Adamson P, Strosberg AD, Couraud PO; ''Growth factor activity of endothelin-1 in primary astrocytes mediated by adhesion-dependent and -independent pathways.''; J Neurosci, 1997 PubMed Europe PMC Scholia
- Jozsef L, Khreiss T, Fournier A, Chan JS, Filep JG; ''Extracellular signal-regulated kinase plays an essential role in endothelin-1-induced homotypic adhesion of human neutrophil granulocytes.''; Br J Pharmacol, 2002 PubMed Europe PMC Scholia
- Nakagawa Y, Kuwahara K, Harada M, Takahashi N, Yasuno S, Adachi Y, Kawakami R, Nakanishi M, Tanimoto K, Usami S, Kinoshita H, Saito Y, Nakao K; ''Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes.''; J Mol Cell Cardiol, 2006 PubMed Europe PMC Scholia
- Gerstung M, Roth T, Dienes HP, Licht C, Fries JW; ''Endothelin-1 induces NF-kappaB via two independent pathways in human renal tubular epithelial cells.''; Am J Nephrol, 2007 PubMed Europe PMC Scholia
- Son GY, Bak EJ, Kim JH, Lee DE, Kang SM, Lee SY, Choi L, Sun JS, Kim SK, Park W, Kim BI, Yoo YJ, Chang I, Shin DM; ''Endothelin Regulates Porphyromonas gingivalis-Induced Production of Inflammatory Cytokines.''; PLoS One, 2016 PubMed Europe PMC Scholia
- Javadov S, Rajapurohitam V, Kilic A, Zeidan A, Choi A, Karmazyn M; ''Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction.''; J Mol Cell Cardiol, 2009 PubMed Europe PMC Scholia
- Shah BH, Baukal AJ, Chen HD, Shah AB, Catt KJ; ''Mechanisms of endothelin-1-induced MAP kinase activation in adrenal glomerulosa cells.''; J Steroid Biochem Mol Biol, 2006 PubMed Europe PMC Scholia
- Akamata K, Asano Y, Aozasa N, Noda S, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Sato S; ''Bosentan reverses the pro-fibrotic phenotype of systemic sclerosis dermal fibroblasts via increasing DNA binding ability of transcription factor Fli1.''; Arthritis Res Ther, 2014 PubMed Europe PMC Scholia
- Masamune A, Satoh M, Kikuta K, Suzuki N, Shimosegawa T; ''Endothelin-1 stimulates contraction and migration of rat pancreatic stellate cells.''; World J Gastroenterol, 2005 PubMed Europe PMC Scholia
- Karoor V, Fini MA, Loomis Z, Sullivan T, Hersh LB, Gerasimovskaya E, Irwin D, Dempsey EC; ''Sustained Activation of Rho GTPases Promotes a Synthetic Pulmonary Artery Smooth Muscle Cell Phenotype in Neprilysin Null Mice.''; Arterioscler Thromb Vasc Biol, 2018 PubMed Europe PMC Scholia
- Isono M, Haneda M, Maeda S, Omatsu-Kanbe M, Kikkawa R; ''Atrial natriuretic peptide inhibits endothelin-1-induced activation of JNK in glomerular mesangial cells.''; Kidney Int, 1998 PubMed Europe PMC Scholia
- Tong XK, Hamel E; ''Transforming growth factor-beta 1 impairs endothelin-1-mediated contraction of brain vessels by inducing mitogen-activated protein (MAP) kinase phosphatase-1 and inhibiting p38 MAP kinase.''; Mol Pharmacol, 2007 PubMed Europe PMC Scholia
- Bao Y, Li R, Jiang J, Cai B, Gao J, Le K, Zhang F, Chen S, Liu P; ''Activation of peroxisome proliferator-activated receptor gamma inhibits endothelin-1-induced cardiachypertrophy via the calcineurin/NFAT signaling pathway.''; Mol Cell Biochem, 2008 PubMed Europe PMC Scholia
- Wu MH, Chen LM, Hsu HH, Lin JA, Lin YM, Tsai FJ, Tsai CH, Huang CY, Tang CH; ''Endothelin-1 enhances cell migration through COX-2 up-regulation in human chondrosarcoma.''; Biochim Biophys Acta, 2013 PubMed Europe PMC Scholia
- Iizuka M, Murata T, Hori M, Ozaki H; ''Increased contractility of hepatic stellate cells in cirrhosis is mediated by enhanced Ca2+-dependent and Ca2+-sensitization pathways.''; Am J Physiol Gastrointest Liver Physiol, 2011 PubMed Europe PMC Scholia
- Li B, Kaetzel MA, Dedman JR; ''Signaling pathways regulating murine cardiac CREB phosphorylation.''; Biochem Biophys Res Commun, 2006 PubMed Europe PMC Scholia
- Jamal S, Schneider RJ; ''UV-induction of keratinocyte endothelin-1 downregulates E-cadherin in melanocytes and melanoma cells.''; J Clin Invest, 2002 PubMed Europe PMC Scholia
- Deng H, Hershenson MB, Lei J, Anyanwu AC, Pinsky DJ, Bentley JK; ''Pulmonary artery smooth muscle hypertrophy: roles of glycogen synthase kinase-3beta and p70 ribosomal S6 kinase.''; Am J Physiol Lung Cell Mol Physiol, 2010 PubMed Europe PMC Scholia
- Araki S, Haneda M, Togawa M, Kikkawa R; ''Endothelin-1 activates c-Jun NH2-terminal kinase in mesangial cells.''; Kidney Int, 1997 PubMed Europe PMC Scholia
- Takahashi H, Takeishi Y, Seidler T, Arimoto T, Akiyama H, Hozumi Y, Koyama Y, Shishido T, Tsunoda Y, Niizeki T, Nozaki N, Abe J, Hasenfuss G, Goto K, Kubota I; ''Adenovirus-mediated overexpression of diacylglycerol kinase-zeta inhibits endothelin-1-induced cardiomyocyte hypertrophy.''; Circulation, 2005 PubMed Europe PMC Scholia
- Rosano L, Spinella F, Di Castro V, Nicotra MR, Dedhar S, de Herreros AG, Natali PG, Bagnato A; ''Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells.''; Cancer Res, 2005 PubMed Europe PMC Scholia
- Tang YC, Liu CW, Chang HH, Juan CC, Kuo YC, Kao CC, Huang YM, Kao YH; ''Endothelin-1 stimulates resistin gene expression.''; Endocrinology, 2014 PubMed Europe PMC Scholia
- Wang L, Proud CG; ''Ras/Erk signaling is essential for activation of protein synthesis by Gq protein-coupled receptor agonists in adult cardiomyocytes.''; Circ Res, 2002 PubMed Europe PMC Scholia
- Montezano AC, Burger D, Paravicini TM, Chignalia AZ, Yusuf H, Almasri M, He Y, Callera GE, He G, Krause KH, Lambeth D, Quinn MT, Touyz RM; ''Nicotinamide adenine dinucleotide phosphate reduced oxidase 5 (Nox5) regulation by angiotensin II and endothelin-1 is mediated via calcium/calmodulin-dependent, rac-1-independent pathways in human endothelial cells.''; Circ Res, 2010 PubMed Europe PMC Scholia
- Gadea A, Schinelli S, Gallo V; ''Endothelin-1 regulates astrocyte proliferation and reactive gliosis via a JNK/c-Jun signaling pathway.''; J Neurosci, 2008 PubMed Europe PMC Scholia
- Weng CM, Yu CC, Kuo ML, Chen BC, Lin CH; ''Endothelin-1 induces connective tissue growth factor expression in human lung fibroblasts by ETAR-dependent JNK/AP-1 pathway.''; Biochem Pharmacol, 2014 PubMed Europe PMC Scholia
- Foschi M, Chari S, Dunn MJ, Sorokin A; ''Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinase.''; EMBO J, 1997 PubMed Europe PMC Scholia
- Takagi Y, Ninomiya H, Sakamoto A, Miwa S, Masaki T; ''Structural basis of G protein specificity of human endothelin receptors. A study with endothelinA/B chimeras.''; J Biol Chem, 1995 PubMed Europe PMC Scholia
- Mori K, Amano M, Takefuji M, Kato K, Morita Y, Nishioka T, Matsuura Y, Murohara T, Kaibuchi K; ''Rho-kinase contributes to sustained RhoA activation through phosphorylation of p190A RhoGAP.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
- McWhinnie R, Pechkovsky DV, Zhou D, Lane D, Halayko AJ, Knight DA, Bai TR; ''Endothelin-1 induces hypertrophy and inhibits apoptosis in human airway smooth muscle cells.''; Am J Physiol Lung Cell Mol Physiol, 2007 PubMed Europe PMC Scholia
- Cianfrocca R, Rosano L, Spinella F, Di Castro V, Natali PG, Bagnato A; ''Beta-arrestin-1 mediates the endothelin-1-induced activation of Akt and integrin-linked kinase.''; Can J Physiol Pharmacol, 2010 PubMed Europe PMC Scholia
- Spinella F, Rosano L, Di Castro V, Nicotra MR, Natali PG, Bagnato A; ''Endothelin-1 decreases gap junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
- Lin CC, Hsieh HL, Chi PL, Yang CC, Hsiao LD, Yang CM; ''Upregulation of COX-2/PGE2 by ET-1 mediated through Ca2+-dependent signals in mouse brain microvascular endothelial cells.''; Mol Neurobiol, 2014 PubMed Europe PMC Scholia
- Foschi M, Franchi F, Han J, La Villa G, Sorokin A; ''Endothelin-1 induces serine phosphorylation of the adaptor protein p66Shc and its association with 14-3-3 protein in glomerular mesangial cells.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
- Mandal A, Shahidullah M, Beimgraben C, Delamere NA; ''The effect of endothelin-1 on Src-family tyrosine kinases and Na,K-ATPase activity in porcine lens epithelium.''; J Cell Physiol, 2011 PubMed Europe PMC Scholia
- Cianfrocca R, Tocci P, Semprucci E, Spinella F, Di Castro V, Bagnato A, Rosano L; ''β-Arrestin 1 is required for endothelin-1-induced NF-κB activation in ovarian cancer cells.''; Life Sci, 2014 PubMed Europe PMC Scholia
- Bisotto S, Fixman ED; ''Src-family tyrosine kinases, phosphoinositide 3-kinase and Gab1 regulate extracellular signal-regulated kinase 1 activation induced by the type A endothelin-1 G-protein-coupled receptor.''; Biochem J, 2001 PubMed Europe PMC Scholia
- Lamers JM, Eskildsen-Helmond YE, Resink AM, de Jonge HW, Bezstarosti K, Sharma HS, van Heugten HA; ''Endothelin-1-induced phospholipase C-beta and D and protein kinase C isoenzyme signaling leading to hypertrophy in rat cardiomyocytes.''; J Cardiovasc Pharmacol, 1995 PubMed Europe PMC Scholia
- Tang L, Luo B, Patel RP, Ling Y, Zhang J, Fallon MB; ''Modulation of pulmonary endothelial endothelin B receptor expression and signaling: implications for experimental hepatopulmonary syndrome.''; Am J Physiol Lung Cell Mol Physiol, 2007 PubMed Europe PMC Scholia
- Wu X, Zhang T, Bossuyt J, Li X, McKinsey TA, Dedman JR, Olson EN, Chen J, Brown JH, Bers DM; ''Local InsP3-dependent perinuclear Ca2+ signalingin cardiac myocyte excitation-transcription coupling.''; J Clin Invest, 2006 PubMed Europe PMC Scholia
- Nemoto S, Taguchi K, Matsumoto T, Kamata K, Kobayashi T; ''Pravastatin normalizes ET-1-induced contraction in the aorta of type 2 diabetic OLETF rats by suppressing the KSR1/ERK complex.''; Am J Physiol Heart Circ Physiol, 2012 PubMed Europe PMC Scholia
- Semprucci E, Tocci P, Cianfrocca R, Sestito R, Caprara V, Veglione M, Castro VD, Spadaro F, Ferrandina G, Bagnato A, Rosano L; ''Endothelin A receptor drives invadopodia function and cell motility through the Beta-arrestin/PDZ-RhoGEF pathway in ovarian carcinoma.''; Oncogene, 2016 PubMed Europe PMC Scholia
- Cianfrocca R, Tocci P, Rosano L, Caprara V, Sestito R, Di Castro V, Bagnato A; ''Nuclear β-arrestin1 is a critical cofactor of hypoxia-inducible factor-1α signaling in endothelin-1-induced ovarian tumor progression.''; Oncotarget, 2016 PubMed Europe PMC Scholia
- Hersch E, Huang J, Grider JR, Murthy KS; ''Gq/G13 signaling by ET-1 in smooth muscle: MYPT1 phosphorylation via ETA and CPI-17 dephosphorylation via ETB.''; Am J Physiol Cell Physiol, 2004 PubMed Europe PMC Scholia
- Davies JC, Bain SC, Kanamarlapudi V; ''ADP-ribosylation factor 6 regulates endothelin-1-induced lipolysis in adipocytes.''; Biochem Pharmacol, 2014 PubMed Europe PMC Scholia
- Chahdi A, Miller B, Sorokin A; ''Endothelin 1 induces beta 1Pix translocationand Cdc42 activation via protein kinase A-dependent pathway.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
- Lima VV, Giachini FR, Carneiro FS, Carvalho MH, Fortes ZB, Webb RC, Tostes RC; ''O-GlcNAcylation contributes to the vascular effects of ET-1 via activation of the RhoA/Rho-kinase pathway.''; Cardiovasc Res, 2011 PubMed Europe PMC Scholia
- Hsieh HL, Lin CC, Chan HJ, Yang CM; ''c-Src-dependent EGF receptor transactivation contributes to ET-1-induced COX-2 expression in brain microvascular endothelial cells.''; J Neuroinflammation, 2012 PubMed Europe PMC Scholia
- Kim SW, Choi HJ, Lee HJ, He J, Wu Q, Langley RR, Fidler IJ, Kim SJ; ''Role of the endothelin axis in astrocyte- and endothelial cell-mediated chemoprotection of cancer cells.''; Neuro Oncol, 2014 PubMed Europe PMC Scholia
- Wu MH, Lo JF, Kuo CH, Lin JA, Lin YM, Chen LM, Tsai FJ, Tsai CH, Huang CY, Tang CH; ''Endothelin-1 promotes MMP-13 production and migration in human chondrosarcoma cells through FAK/PI3K/Akt/mTOR pathways.''; J Cell Physiol, 2012 PubMed Europe PMC Scholia
- Lin CC, Lin WN, Hou WC, Hsiao LD, Yang CM; ''Endothelin-1 induces VCAM-1 expression-mediated inflammation via receptor tyrosine kinases and Elk/p300 in human tracheal smooth muscle cells.''; Am J Physiol Lung Cell Mol Physiol, 2015 PubMed Europe PMC Scholia
- Rufanova VA, Alexanian A, Wakatsuki T, Lerner A, Sorokin A; ''Pyk2 mediates endothelin-1 signaling via p130Cas/BCAR3 cascade and regulates human glomerular mesangial cell adhesion and spreading.''; J Cell Physiol, 2009 PubMed Europe PMC Scholia
- Häuselmann SP, Rosc-Schlüter BI, Lorenz V, Plaisance I, Brink M, Pfister O, Kuster GM; ''β1-Integrin is up-regulated via Rac1-dependent reactive oxygen species as part of the hypertrophic cardiomyocyte response.''; Free Radic Biol Med, 2011 PubMed Europe PMC Scholia
- Asada S, Takanami-Ohnishi Y, Zhou J, Hama H, Fukamizu A, Kimura S, Goto K, Kasuya Y; ''Cytodifferentiation enhances Erk activation induced by endothelin-1 in primary cultured astrocytes.''; J Cardiovasc Pharmacol, 2004 PubMed Europe PMC Scholia
- Dao HH, Bouvet C, Moreau S, Beaucage P, Larivière R, Servant MJ, de Champlain J, Moreau P; ''Endothelin is a dose-dependent trophic factor and a mitogen in small arteries in vivo.''; Cardiovasc Res, 2006 PubMed Europe PMC Scholia
- Rosano L, Cianfrocca R, Masi S, Spinella F, Di Castro V, Biroccio A, Salvati E, Nicotra MR, Natali PG, Bagnato A; ''Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis.''; Proc Natl Acad Sci U S A, 2009 PubMed Europe PMC Scholia
- Schinelli S, Zanassi P, Paolillo M, Wang H, Feliciello A, Gallo V; ''Stimulation of endothelin B receptors in astrocytes induces cAMP response element-binding protein phosphorylation and c-fos expression via multiple mitogen-activated protein kinase signaling pathways.''; J Neurosci, 2001 PubMed Europe PMC Scholia
- Xu H, Zhou Y, Lu C, Ping J, Xu LM; ''Salvianolic acid B lowers portal pressure in cirrhotic rats and attenuates contraction of rat hepatic stellate cells by inhibiting RhoA signaling pathway.''; Lab Invest, 2012 PubMed Europe PMC Scholia
- Kawanabe Y, Nozaki K, Hashimoto N, Masaki T; ''Involvement of extracellular Ca2+ influx and epidermal growth factor receptor tyrosine kinase transactivation in endothelin-1-induced arachidonic acid release.''; Br J Pharmacol, 2003 PubMed Europe PMC Scholia
- Yang LL, Gros R, Kabir MG, Sadi A, Gotlieb AI, Husain M, Stewart DJ; ''Conditional cardiac overexpression of endothelin-1 induces inflammation and dilated cardiomyopathy in mice.''; Circulation, 2004 PubMed Europe PMC Scholia
- Rosano L, Cianfrocca R, Tocci P, Spinella F, Di Castro V, Caprara V, Semprucci E, Ferrandina G, Natali PG, Bagnato A; ''Endothelin A receptor Beta-arrestin signaling to the Wnt pathway renders ovarian cancer cells resistant to chemotherapy.''; Cancer Res, 2014 PubMed Europe PMC Scholia
- Cazaubon SM, Ramos-Morales F, Fischer S, Schweighoffer F, Strosberg AD, Couraud PO; ''Endothelin induces tyrosine phosphorylation and GRB2 association of Shc in astrocytes.''; J Biol Chem, 1994 PubMed Europe PMC Scholia
- Dlugosz JA, Munk S, Ispanovic E, Goldberg HJ, Whiteside CI; ''Mesangial cell filamentous actin disassembly and hypocontractility in high glucose are mediated by PKC-zeta.''; Am J Physiol Renal Physiol, 2002 PubMed Europe PMC Scholia
- Fernandez-Patron C, Zouki C, Whittal R, Chan JS, Davidge ST, Filep JG; ''Matrix metalloproteinases regulate neutrophil-endothelial cell adhesion through generation of endothelin-1[1-32].''; FASEB J, 2001 PubMed Europe PMC Scholia
- Imamura T, Ishibashi K, Dalle S, Ugi S, Olefsky JM; ''Endothelin-1-induced GLUT4 translocation is mediated via Galpha(q/11) protein and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes.''; J Biol Chem, 1999 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
Cardiac hypertrophy | |||
ABHD3 | GeneProduct | 171586 (Entrez Gene) | |
ABL1 | Protein | NP_009297.2 (NCBI Protein) | |
ACTA2 | GeneProduct | 59 (Entrez Gene) | |
ACTG2 | GeneProduct | 72 (Entrez Gene) | |
ACTR1A | GeneProduct | 10121 (Entrez Gene) | |
ACTR2 | GeneProduct | 10097 (Entrez Gene) | |
ACTR3 | GeneProduct | 10096 (Entrez Gene) | |
ADAM12 | GeneProduct | ADAM12 | |
ADAM17 | GeneProduct | 6868 (Entrez Gene) | |
ADAM19 | GeneProduct | ADAM19 | |
ADIPOQ | GeneProduct | 9370 (Entrez Gene) | |
AKT1 | Protein | NP_005154.2 (NCBI Protein) | |
ANXA7 | GeneProduct | 310 (Entrez Gene) | |
ARF6 | GeneProduct | 382 (Entrez Gene) | |
ARHGAP35 | Protein | NP_004482.4 (NCBI Protein) | |
ARHGEF11 | GeneProduct | ARHGEF11 | |
ARHGEF7 | GeneProduct | 8874 (Entrez Gene) | |
ARL6IP5 | GeneProduct | 10550 (Entrez Gene) | |
ARPC4 | GeneProduct | 10093 (Entrez Gene) | |
ARRB1 | GeneProduct | 408 (Entrez Gene) | |
ARRB1 | GeneProduct | ARRB1 | |
ATF1 | Protein | NP_005162.1 (NCBI Protein) | |
ATF2 | Protein | NP_001871.2 (NCBI Protein) | |
ATP6V1H | GeneProduct | 51606 (Entrez Gene) | |
ATRX | GeneProduct | 546 (Entrez Gene) | |
AXIN1 | GeneProduct | 8312 (Entrez Gene) | |
Actin polymerization | Pathway | ||
B3GNT2 | GeneProduct | 10678 (Entrez Gene) | |
BAD | Protein | ||
BCAR1 | GeneProduct | 9564 (Entrez Gene) | |
BCAR3 | GeneProduct | 8412 (Entrez Gene) | |
BCL2 | GeneProduct | 596 (Entrez Gene) | |
BMI1 | GeneProduct | 648 (Entrez Gene) | |
Blood vessel contraction | |||
Brain inflamation disorders | |||
CALD1 | GeneProduct | 800 (Entrez Gene) | |
CALD1 | Protein | NP_149129.2 (NCBI Protein) | |
CALM1 | GeneProduct | 801 (Entrez Gene) | |
CAMK2A | Protein | NP_057065.2 (NCBI Protein) | |
CAMK2G | Protein | 5970 (Entrez Gene) | |
CAPZB | GeneProduct | 832 (Entrez Gene) | |
CASP8 | GeneProduct | 841 (Entrez Gene) | |
CCL2 | GeneProduct | 6347 (Entrez Gene) | |
CCN2 | GeneProduct | 1490 (Entrez Gene) | |
CCNB1 | GeneProduct | 891 (Entrez Gene) | |
CCND1 | GeneProduct | 595 (Entrez Gene) | |
CCS differentiation | Pathway | ||
CDC42 | GeneProduct | 998 (Entrez Gene) | |
CDH1 | GeneProduct | 999 (Entrez Gene) | |
CDH2 | GeneProduct | 1000 (Entrez Gene) | |
CDK2 | GeneProduct | 1017 (Entrez Gene) | |
CDKN1B | Protein | NP_004055.1 (NCBI Protein) | |
CFL1 | Protein | NP_005498.1 (NCBI Protein) | |
CFL2 | Protein | NP_068733.1 (NCBI Protein) | |
CHUK | Protein | NP_001269.3 (NCBI Protein) | |
COL1A1 | GeneProduct | 1277 (Entrez Gene) | |
COL1A2 | GeneProduct | 1278 (Entrez Gene) | |
COL1A3 | GeneProduct | 1279 (Entrez Gene) | |
COL1A4 | GeneProduct | 1280 (Entrez Gene) | |
COL4A1 | GeneProduct | COL4A1 | |
COL5A1 | GeneProduct | COL5A1 | |
COL7A1 | GeneProduct | COL7A1 | |
COL9A1 | GeneProduct | 1297 (Entrez Gene) | |
COMP | GeneProduct | COMP | |
COX1 | GeneProduct | 4512 (Entrez Gene) | |
COX2 | GeneProduct | 4513 (Entrez Gene) | |
CREB1 | GeneProduct | NP_604391.1 (NCBI Protein) | |
CREB | Protein | NP_604391.1 (NCBI Protein) | |
CREG1 | GeneProduct | 8804 (Entrez Gene) | |
CRYZL1 | GeneProduct | 9946 (Entrez Gene) | |
CSF2 | GeneProduct | 1437 (Entrez Gene) | |
CTNNB1 | GeneProduct | 1499 (Entrez Gene) | |
CTNND1 | GeneProduct | 1500 (Entrez Gene) | |
CX3CL1 | GeneProduct | 6376 (Entrez Gene) | |
CXCL1 | GeneProduct | 2919 (Entrez Gene) | |
CXCL8 | GeneProduct | 3576 (Entrez Gene) | |
Cell invasion | |||
Cell invasion | |||
Cell migration | |||
Cell survival
and angiogenesis | Pathway | ||
Cellular proliferation, migration and contraction in colon cancer adjacent fibroblasts | |||
Chemo protection | |||
Cytoplasm | Pathway | ||
Cytoskeletal polymerisation | |||
DAG1 | Protein | ||
DAZAP2 | GeneProduct | 9802 (Entrez Gene) | |
DLAT | GeneProduct | 1737 (Entrez Gene) | |
DNAJC10 | GeneProduct | 54431 (Entrez Gene) | |
DNAJC12 | GeneProduct | 56521 (Entrez Gene) | |
E2F3 | GeneProduct | 1871 (Entrez Gene) | |
ECM contraction | |||
EDN1 | Protein | 1906 (Entrez Gene) | |
EDN3 | Protein | 1908 (Entrez Gene) | |
EDNRA | Protein | 1909 (Entrez Gene) | |
EDNRB | Protein | 1910 (Entrez Gene) | |
EGFR | Protein | 1956 (Entrez Gene) | |
EGR1 | GeneProduct | 1958 (Entrez Gene) | |
EIF2B | Protein | NP_001305894.1 (NCBI Protein) | |
EIF5B | GeneProduct | 9669 (Entrez Gene) | |
ELK1 | Protein | NP_005220.2 (NCBI Protein) | |
EMC1 | GeneProduct | 23065 (Entrez Gene) | |
EP2 | Protein | 5732 (Entrez Gene) | |
EP300 | Protein | NP_001420.2 (NCBI Protein) | |
EP4 | Protein | 5734 (Entrez Gene) | |
EPHA2 | GeneProduct | 1969 (Entrez Gene) | |
EZR | GeneProduct | 7430 (Entrez Gene) | |
Epithelial to mesenchymal transition (EMT) | |||
FASTKD1 | GeneProduct | 79675 (Entrez Gene) | |
FGF2 | GeneProduct | FGF2 | |
FHL2 | GeneProduct | 2274 (Entrez Gene) | |
FLI1 | Protein | NP_002008.2 (NCBI Protein) | |
FLNB | GeneProduct | 2317 (Entrez Gene) | |
FLNC | GeneProduct | 2318 (Entrez Gene) | |
FNDC1 | GeneProduct | 84624 (Entrez Gene) | |
FNDC3B | GeneProduct | 64778 (Entrez Gene) | |
FOS | GeneProduct | 2353 (Entrez Gene) | |
FOXK2 | GeneProduct | 3607 (Entrez Gene) | |
FOXO3 | Protein | NP_001446.1 (NCBI Protein) | |
FYN | Protein | NP_002028.1 (NCBI Protein) | |
G-protein dependent | Pathway | ||
GAB1 | Protein | NP_997006.1 (RefSeq) | |
GALNT1 | GeneProduct | 2589 (Entrez Gene) | |
GATA4 | GeneProduct | 2626 (Entrez Gene) | |
GATA4 | Protein | NP_001295022.1 (NCBI Protein) | |
GGA2 | GeneProduct | 23062 (Entrez Gene) | |
GJA5 | GeneProduct | 2702 (Entrez Gene) | |
GJC1 | GeneProduct | 10052 (Entrez Gene) | |
GLS | GeneProduct | 2744 (Entrez Gene) | |
GNA12 | GeneProduct | 2768 (Entrez Gene) | |
GNA13 | GeneProduct | 10672 (Entrez Gene) | |
GNAQ | GeneProduct | 10672 (Entrez Gene) | |
GNAS | GeneProduct | 2778 (Entrez Gene) | |
GOLGB1 | GeneProduct | 2804 (Entrez Gene) | |
GRB2 | GeneProduct | 2885 (Entrez Gene) | |
GSK3B | GeneProduct | 2932 (Entrez Gene) | |
GSN | GeneProduct | 2934 (Entrez Gene) | |
GSTA5 | GeneProduct | 221357 (Entrez Gene) | |
GULP1 | GeneProduct | 51454 (Entrez Gene) | |
HDAC5 | GeneProduct | 10014 (Entrez Gene) | |
HIF1A | GeneProduct | 3091 (Entrez Gene) | |
HLA-A | GeneProduct | 3105 (Entrez Gene) | |
HOPX | GeneProduct | 84525 (Entrez Gene) | |
HSPB1 | Protein | NP_001531.1 (NCBI Protein) | |
HTATSF1 | GeneProduct | 27336 (Entrez Gene) | |
Hypoxia | Pathway | ||
IGFBP4 | GeneProduct | 3487 (Entrez Gene) | |
IGFBP5 | GeneProduct | 3488 (Entrez Gene) | |
IKBKB | Protein | NP_001547.1 (NCBI Protein) | |
IL11 | GeneProduct | 3589 (Entrez Gene) | |
IL1B | GeneProduct | 3553 (Entrez Gene) | |
IL6 | GeneProduct | 3569 (Entrez Gene) | |
ILK | GeneProduct | 3611 (Entrez Gene) | |
IPK1 | GeneProduct | ||
IRS1 | Protein | ||
IRX4 | GeneProduct | 50805 (Entrez Gene) | |
ISCA1 | GeneProduct | 81689 (Entrez Gene) | |
ITGA2 | GeneProduct | 3673 (Entrez Gene) | |
ITGA2 | GeneProduct | ITGA2 | |
ITGA5 | GeneProduct | ITGA5 | |
ITGB1 | GeneProduct | 3688 (Entrez Gene) | |
ITGB1BP1 | GeneProduct | 9270 (Entrez Gene) | |
ITGB3 | GeneProduct | 3690 (Entrez Gene) | |
ITGB3 | GeneProduct | ITGB3 | |
Inflammation | Pathway | ||
Invasion
and metastasis | |||
JAK1 | Protein | NP_002218.2 (NCBI Protein) | |
JUN | GeneProduct | 3725 (Entrez Gene) | |
JUN | Protein | NP_002219.1 (NCBI Protein) | |
KCNK3 | GeneProduct | 3777 (Entrez Gene) | |
KDM5B | GeneProduct | 10765 (Entrez Gene) | |
KLHL20 | GeneProduct | 27252 (Entrez Gene) | |
KRAS | GeneProduct | 3845 (Entrez Gene) | |
KSR1 | Protein | NP_055053.1 (RefSeq) | |
LEPR | GeneProduct | 3953 (Entrez Gene) | |
LIMK | Protein | NP_002305.1 (NCBI Protein) | |
Lung fibrosis | Pathway | ||
MAP2K1 | GeneProduct | 5604 (Entrez Gene) | |
MAP2K2 | Protein | NP_109587.1 (RefSeq) | |
MAP3K2 | GeneProduct | 10746 (Entrez Gene) | |
MAPK14 | Protein | NP_001306.1 (NCBI Protein) | |
MAPK1 | GeneProduct | 5594 (Entrez Gene) | |
MAPK3 | GeneProduct | 5595 (Entrez Gene) | |
MAPK8 | Protein | NP_001310259.1 (NCBI Protein) | |
MAPK9 | Protein | NP_002743.3 (NCBI Protein) | |
MARCKS | GeneProduct | 4082 (Entrez Gene) | |
MCAM | GeneProduct | 4162 (Entrez Gene) | |
MED12 | GeneProduct | 9968 (Entrez Gene) | |
MEF2A | GeneProduct | 4205 (Entrez Gene) | |
MINK1 | GeneProduct | 50488 (Entrez Gene) | |
MLC | Protein | NP_055981.1 (NCBI Protein) | |
MLCK | GeneProduct | 4638 (Entrez Gene) | |
MMP13 | GeneProduct | 4322 (Entrez Gene) | |
MMP14 | GeneProduct | 4323 (Entrez Gene) | |
MMP1 | GeneProduct | MMP1 | |
MMP2 | GeneProduct | 4313 (Entrez Gene) | |
MMP3 | GeneProduct | MMP3 | |
MMP9 | GeneProduct | 4318 (Entrez Gene) | |
MPP5 | GeneProduct | 64398 (Entrez Gene) | |
MPPED2 | GeneProduct | 744 (Entrez Gene) | |
MSN | GeneProduct | 4478 (Entrez Gene) | |
MTOR | Protein | NP_004949.1 (NCBI Protein) | |
MYBPC3 | GeneProduct | 4607 (Entrez Gene) | |
MYH11 | Protein | 4629 (Entrez Gene) | |
MYL12B | Protein | NP_001138416.1 (NCBI Protein) | |
MYO1B | GeneProduct | 4430 (Entrez Gene) | |
Metastasis
and tumor progression | |||
NAA16 | GeneProduct | 79612 (Entrez Gene) | |
NAA50 | GeneProduct | 80218 (Entrez Gene) | |
NFATC1 | Protein | NP_001265598.1 (NCBI Protein) | |
NFKB1 | Protein | 4790 (Entrez Gene) | |
NFKBIA | Protein | 4792 (Entrez Gene) | |
NKX2-5 | GeneProduct | 1482 (Entrez Gene) | |
NO accumulation | Pathway | ||
NOL8 | GeneProduct | 55035 (Entrez Gene) | |
NOS3 | GeneProduct | 4846 (Entrez Gene) | |
NOS3 | Protein | NP_000594.2 (NCBI Protein) | |
NPPA | GeneProduct | 4878 (Entrez Gene) | |
NPPB | GeneProduct | 4879 (Entrez Gene) | |
NQO1 | GeneProduct | 1728 (Entrez Gene) | |
Nucleus | Pathway | ||
P4HB | GeneProduct | 5034 (Entrez Gene) | |
PAK1 | GeneProduct | 5058 (Entrez Gene) | |
PIK3CA | GeneProduct | 5290 (Entrez Gene) | |
PKC | GeneProduct | 5566 (Entrez Gene) | |
PLA2G1B | Protein | P04054 (Uniprot-TrEMBL) | |
PLCB1 | GeneProduct | 23236 (Entrez Gene) | |
PLOD2 | GeneProduct | PLOD2 | |
PPP1R12A | GeneProduct | 4659 (Entrez Gene) | |
PPP1R12A | Protein | NP_002471.1 (NCBI Protein) | |
PPP1R14A | Protein | ||
PPP3CA | GeneProduct | 5530 (Entrez Gene) | |
PRKACA | GeneProduct | 5566 (Entrez Gene) | |
PRKCA | GeneProduct | 5578 (Entrez Gene) | |
PTGS2 | GeneProduct | 5743 (Entrez Gene) | |
PTK2 | Protein | ||
PTK2B | GeneProduct | 2185 (Entrez Gene) | |
PXN | GeneProduct | 5829 (Entrez Gene) | |
Pulmonary hypertension | Pathway | ||
RAB5C | GeneProduct | 5878 (Entrez Gene) | |
RAC1 | GeneProduct | 5879 (Entrez Gene) | |
RAC1 | GeneProduct | 5879 (Entrez Gene) | |
RAF1 | GeneProduct | 5894 (Entrez Gene) | |
RAP1GAP | GeneProduct | 5909 (Entrez Gene) | |
RDX | GeneProduct | 5962 (Entrez Gene) | |
RELA | Protein | 5970 (Entrez Gene) | |
RGS3 | GeneProduct | 5998 (Entrez Gene) | |
RHOA | GeneProduct | 387 (Entrez Gene) | |
RHOC | Protein | 389 (Entrez Gene) | |
ROCK1 | GeneProduct | 6093 (Entrez Gene) | |
RPS6KA2 | Protein | NP_001305865.1 (NCBI Protein) | |
RPS6KA3 | Protein | NP_004577.1 (NCBI Protein) | |
RPS6KB1 | Protein | NP_003152.1 (NCBI Protein) | |
RPS6 | Protein | NP_001001.2 (NCBI Protein) | |
RUNX1 | GeneProduct | 861 (Entrez Gene) | |
Renal fibrosis | |||
SDC1 | GeneProduct | SDC1 | |
SHC1 | GeneProduct | 6464 (Entrez Gene) | |
SHC1 | GeneProduct | 6464 (Entrez Gene) | |
SMAD5 | GeneProduct | 4090 (Entrez Gene) | |
SNAI1 | GeneProduct | 6615 (Entrez Gene) | |
SOS1 | GeneProduct | 6654 (Entrez Gene) | |
SP4 | GeneProduct | 6671 (Entrez Gene) | |
SRC | GeneProduct | 6714 (Entrez Gene) | |
SRE | GeneProduct | serum response element (Other) | |
SSH1 | GeneProduct | 54434 (Entrez Gene) | |
STAT3 | Protein | NP_644805.1 (NCBI Protein) | |
STOM | GeneProduct | 2040 (Entrez Gene) | |
Smooth muscle differentiation | Pathway | ||
TAGLN2 | GeneProduct | 8407 (Entrez Gene) | |
TCF4 | GeneProduct | 6925 (Entrez Gene) | |
THBS1 | GeneProduct | THBS1 | |
TIMP3 | GeneProduct | TIMP3 | |
TNF | GeneProduct | 7124 (Entrez Gene) | |
TNS1 | GeneProduct | 7145 (Entrez Gene) | |
TPM1 | GeneProduct | 7168 (Entrez Gene) | |
TPM4 | GeneProduct | 7171 (Entrez Gene) | |
TRAFD1 | GeneProduct | 10906 (Entrez Gene) | |
TRIOBP | GeneProduct | 11078 (Entrez Gene) | |
TWIST1 | GeneProduct | 17291 (Entrez Gene) | |
VCAM1 | GeneProduct | 7412 (Entrez Gene) | |
VCAN | GeneProduct | VCAN | |
VEGFA | GeneProduct | 7422 (Entrez Gene) | |
VIL1 | GeneProduct | 7429 (Entrez Gene) | |
VIM | GeneProduct | 7431 (Entrez Gene) | |
WIPF1 | GeneProduct | 7456 (Entrez Gene) | |
WNK1 | GeneProduct | 65125 (Entrez Gene) | |
WWTR1 | GeneProduct | 25937 (Entrez Gene) | |
YAP1 | GeneProduct | 10413 (Entrez Gene) | |
YWHAQ | GeneProduct | 10971 (Entrez Gene) | |
ZFYVE16 | GeneProduct | 9765 (Entrez Gene) | |
ZNF131 | GeneProduct | 7690 (Entrez Gene) | |
ZNF136 | GeneProduct | 7695 (Entrez Gene) | |
β-arrestin dependent | Pathway |
Annotated Interactions
No annotated interactions