Host-pathogen interaction of human coronaviruses - apoptosis (Homo sapiens)

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211death receptorsmitochondriaOC43infectionApoptosisApoptosomeSARSFADDECASP8TNFMCL1MAPK12BCL2tBIDAPAF1AKT1Cytochrome CFASLGBCL2L11BBC3MBADCASP3BIDCASP9MAPK11BAXCASP71BCL2L1BAX7aOC43 infectionMAPK13MAPK14SARS3ap38SARSSSARSEN3b68a9bvirus proteinvirus type/speciesSARS


This pathway describes the induction and modulation of the apoptosis system during human coronavirus infection. The information is based on the review of Fung and Liu [10.1146/annurev-micro-020518-115759]. Apoptosis is a highly controlled form of cell death that can be initiated by several internal (DNA damage) and external factors (T-cell death signal). There are some indications that induction of apoptosis in immune cells contribute to the suppression of the host immune system in some human coronavirus infections [10.1128/JVI.00269-12]. SARS-CoV induces caspase-dependent apoptosis by interfering with prosurvival BCL proteins (BCL2, BCL2L1, MCL1) and AKT1 and uses the apoptosis induced cell deconstruction it for replication, although it seems not to be depending on this mechanism for replication [10.1016/j.virusres.2014.09.016].

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Ontology Terms



  1. Li H, Zhu H, Xu CJ, Yuan J; ''Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.''; Cell, 1998 PubMed Europe PMC Scholia
  2. Fung TS, Liu DX; ''Human Coronavirus: Host-Pathogen Interaction.''; Annu Rev Microbiol, 2019 PubMed Europe PMC Scholia


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124634view12:40, 18 November 2022NhungPupdate viral protein shapes
124632view12:33, 18 November 2022NhungPchange viral proteins shapes
116596view19:12, 8 May 2021EweitzModified title
113801view09:33, 25 November 2020NhungPAnnotated protein 8a and updated protein S and N identifiers
111622view18:17, 30 August 2020Egonw
111365view05:33, 3 August 2020EgonwConverted two interacting Label's to DataNode's.
110821view07:59, 10 June 2020FehrhartModified description
110242view17:35, 29 April 2020EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
110205view10:49, 24 April 2020Fehrhartupdated legend and labels
110200view20:39, 23 April 2020EgonwTyped proteins as Type="Protein"
109973view18:18, 8 April 2020AlexanderPicoupdated sars nodes per #covidpathways guidelines
109950view18:21, 7 April 2020MaintBotAdded two more identifiers.
109876view10:08, 3 April 2020Fehrhartadded information about tBID
109849view11:36, 2 April 2020Fehrhartchanged virus protein visualization
109819view14:57, 1 April 2020Fehrhartadded protein ID for M
109818view14:56, 1 April 2020Fehrhartadded some virus protein IDs
109639view19:00, 27 March 2020FehrhartOntology Term : 'apoptotic cell death pathway' added !
109638view18:59, 27 March 2020FehrhartOntology Term : 'disease pathway' added !
109637view18:59, 27 March 2020FehrhartOntology Term : 'viral infectious disease' added !
109636view18:59, 27 March 2020FehrhartOntology Term : 'severe acute respiratory syndrome' added !
109635view18:56, 27 March 2020FehrhartNew pathway

External references


View all...
NameTypeDatabase referenceComment
3aProteinP59632 (Uniprot-TrEMBL)
3bProteinP59633 (Uniprot-TrEMBL)
6ProteinP59634 (Uniprot-TrEMBL)
7aProteinP59635 (Uniprot-TrEMBL)
8aProteinQ7TFA0 (Uniprot-TrEMBL)
9bProteinP59636 (Uniprot-TrEMBL)
AKT1GeneProduct207 (Entrez Gene)
APAF1GeneProductENSG00000120868 (Ensembl)
BADGeneProductENSG00000002330 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BBC3GeneProductENSG00000105327 (Ensembl) PUMA
BCL2GeneProductENSG00000171791 (Ensembl)
BCL2L11GeneProductENSG00000153094 (Ensembl) BIM
BCL2L1GeneProductENSG00000171552 (Ensembl)
BIDGeneProductENSG00000015475 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP7GeneProductENSG00000165806 (Ensembl)
CASP8GeneProductENSG00000064012 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
Cytochrome CMetaboliteCHEBI:18070 (ChEBI)
EProteinP59637 (Uniprot-TrEMBL)
FADDGeneProductENSG00000168040 (Ensembl)
FASLGGeneProductENSG00000117560 (Ensembl)
MAPK11GeneProductENSG00000185386 (Ensembl)
MAPK12GeneProductENSG00000188130 (Ensembl)
MAPK13GeneProductENSG00000156711 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MCL1GeneProductENSG00000143384 (Ensembl)
MProteinP59596 (Uniprot-TrEMBL)
NProteinP59595 (Uniprot-TrEMBL)
OC43 infectionPathway
OC43 infectionPathway
SProteinP59594 (Uniprot-TrEMBL)
TNFGeneProductENSG00000232810 (Ensembl)
tBIDGeneProductPRO_0000223233 (Uniprot-TrEMBL) BH3-interacting domain death agonist, truncated, p15

Annotated Interactions

No annotated interactions

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