Peroxiredoxin 2 induced ovarian failure (Homo sapiens)

Description

This pathway summarizes the influence of reactive oxygen species on ovarian aging, ovarian failure and therefore female infertility.

HomologyMapper: This pathway was inferred from Mus musculus pathway [WP4835_109250.gpml] with a 62.0% conversion rate.

View approved pathways at the new wikipathways.org.

Park SJ, Kim JH, Lee DG, Kim JM, Lee DS; ''Peroxiredoxin 2 deficiency accelerates age-related ovarian failure through the reactive oxygen species-mediated JNK pathway in mice.''; Free Radic Biol Med, 2018 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
110299	view	15:10, 2 May 2020	Egonw	Replaced secondary ChEBI identifiers with a primary identifiers.
110067	view	08:43, 16 April 2020	Fehrhart	Ontology Term : 'ovarian dysfunction' added !
110066	view	08:42, 16 April 2020	Fehrhart	Ontology Term : 'c-Jun N-terminal kinases MAPK signaling pathway' added !
110065	view	08:41, 16 April 2020	Fehrhart	Modified description
110064	view	08:39, 16 April 2020	Fehrhart	Graphical adjustments
110063	view	08:37, 16 April 2020	Fehrhart	Added reference
109748	view	15:08, 30 March 2020	Bas Lahaije	New pathway

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Name	Type	Database reference	Comment
BAX	GeneProduct	ENSG00000087088 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000003873
CASP3	Protein	ENSG00000164305 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:A0A1B0GRX1
CYP11A1	Protein	ENSG00000140459 (Ensembl)	Mitochondrial Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9QZ82
Cytochrome C	Metabolite	CHEBI:18070 (ChEBI)	Somatic Multiple homologues found: En:ENSG00000172115;En:ENSG00000172115;
Estradiol-17beta	Metabolite	CHEBI:16469 (ChEBI)
HSD3B2	Protein	ENSG00000203859 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:E9PXG7
JNK	Protein	P53779 (Uniprot-TrEMBL)
PARP2	GeneProduct	ENSG00000129484 (Ensembl)
Peroxiredoxin-2	Protein	P32119 (Uniprot-TrEMBL)	No homologues found for original id S:Q61171
Progesterone	Metabolite	DB00396 (DrugBank)
Reactive oxygen species	Metabolite	CHEBI:26523 (ChEBI)
STAR	Protein	ENSG00000147465 (Ensembl)	Mitichondrial Type your comment here Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:P51557

No annotated interactions