Pathogenesis of SARS-CoV-2 mediated by nsp9-nsp10 complex (Homo sapiens)

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ActivationNeutrophil activation T cell surface moleculesT cell receptor(TCR) subunitsChemotaxisImmunoglobulin subunitsTCR signaling kinasesMHC class II moleculesCD2LBPPRG3CD8BIGHEHLA-DRANLRP1nsp10HLA-DRB5CD8AHLA-DRB1CRPIGHG1IGLC2MMP25nsp9SARS-CoV-2 ORFsNKRFIGHG4IGHG2CD4IL-8HLA-DRB4IGLL1IL-61CD247CD3GLCKCD3EZAP70TRBC1FYNTRACNegative regulation of gene expressionPositive regulation of gene expression


Description

Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis

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Ontology Terms

 

Bibliography

  1. Qiming Liang, Jingjiao Li, Mingquan Guo, Xiaoxu Tian, Chengrong Liu, Xin Wang, Xing Yang, Ping Wu, Zixuan Xiao, View ORCID ProfileYafei Qu, Yue Yin, Joyce Fu, Zhaoqin Zhu, Zhenshan Liu, Chao Peng, Tongyu Zhu; ''Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis''; https://doi.org/10.1101/2020.03.31.019216, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
124646view13:05, 18 November 2022IsabelWassinkChanged viral protein shape to rounded rectangles
120646view15:34, 22 December 2021EweitzTighten graphics, fix labels
119112view13:26, 17 June 2021Finterlyadded PMID
118879view12:06, 3 June 2021EweitzOntology Term : 'COVID-19' added !
116727view10:25, 11 May 2021EweitzModified title
111618view20:42, 29 August 2020EgonwModified title
111113view09:20, 13 July 2020EgonwMade the include pathway clickable
110229view14:23, 27 April 2020EgonwAdded the NCBI gene identifier for LBP
110023view19:22, 12 April 2020AlexanderPicoOntology Term : 'regulatory pathway' added !
110022view19:21, 12 April 2020AlexanderPicoOntology Term : 'inflammatory response pathway' added !
110021view19:21, 12 April 2020AlexanderPicoOntology Term : 'disease pathway' added !
110020view19:20, 12 April 2020AlexanderPicoOntology Term : 'severe acute respiratory syndrome' added !
110019view19:20, 12 April 2020AlexanderPicoModified title
110017view19:18, 12 April 2020AlexanderPicoUpdated representation of ORFs and interactions per standards
109953view18:43, 7 April 2020EgonwAdded two identifiers.
109923view17:40, 6 April 2020Khanspersfixed unconnected
109916view16:58, 6 April 2020KhanspersOntology Term : 'viral infectious disease' added !
109904view19:59, 5 April 2020Rex D A BInteractions
109895view18:25, 4 April 2020Rex D A BNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CD247GeneProduct919 (Entrez Gene)
CD2GeneProduct914 (Entrez Gene)
CD3EGeneProduct916 (Entrez Gene)
CD3G GeneProduct917 (Entrez Gene)
CD4GeneProduct920 (Entrez Gene)
CD8AGeneProduct925 (Entrez Gene)
CD8BGeneProduct926 (Entrez Gene)
CRPGeneProduct1401 (Entrez Gene)
FYNGeneProduct2534 (Entrez Gene)
HLA-DRAGeneProduct3122 (Entrez Gene)
HLA-DRB1GeneProduct3123 (Entrez Gene)
HLA-DRB4GeneProduct3126 (Entrez Gene)
HLA-DRB5GeneProduct3127 (Entrez Gene)
IGHEGeneProduct3497 (Entrez Gene)
IGHG1GeneProduct3500 (Entrez Gene)
IGHG2GeneProduct3501 (Entrez Gene)
IGHG4GeneProduct3503 (Entrez Gene)
IGLC2GeneProduct3538 (Entrez Gene)
IGLL1GeneProduct3543 (Entrez Gene)
IL-6GeneProduct3569 (Entrez Gene)
IL-8GeneProduct3576 (Entrez Gene)
LBPGeneProduct3929 (Entrez Gene)
LCKGeneProduct3932 (Entrez Gene)
MMP25 GeneProduct64386 (Entrez Gene)
NKRFGeneProduct55922 (Entrez Gene)
NLRP1GeneProduct5725029 (Entrez Gene)
PRG3GeneProduct10394 (Entrez Gene)
SARS-CoV-2 ORFsPathwayWP4846 (WikiPathways)
TRACGeneProduct28755 (Entrez Gene)
TRBC1 GeneProduct28639 (Entrez Gene)
ZAP70GeneProduct7535 (Entrez Gene)
nsp10ProteinQ87917572 (Wikidata)
nsp9ProteinQ89686805 (Wikidata)

Annotated Interactions

No annotated interactions

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