LDLRAD4 and what we know about it (Homo sapiens)

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194562, 7, 851063BloodpressureAutophagosomeformationNeurodevelopmentaldisordersEbola viruspathway in hostATG16L1NEDD4PMEPA1TGFBR2hsa-miR-20a-5pSMAD2LDLRAD4LDLRAD4-AS1TGF-B signalingpathwayLDLRAD4SMAD2TGFBR1LDLRAD4NEDD4


A recent GWAS study was tweeted (https://twitter.com/BrentRichards19/status/1251550109931888643) showing an intronic SNP in LDLRAD4 as relevant. This pathway summarizes what is known of the biological role of this gene and its proteins.

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  1. Huttlin EL, Ting L, Bruckner RJ, Gebreab F, Gygi MP, Szpyt J, Tam S, Zarraga G, Colby G, Baltier K, Dong R, Guarani V, Vaites LP, Ordureau A, Rad R, Erickson BK, Wühr M, Chick J, Zhai B, Kolippakkam D, Mintseris J, Obar RA, Harris T, Artavanis-Tsakonas S, Sowa ME, De Camilli P, Paulo JA, Harper JW, Gygi SP; ''The BioPlex Network: A Systematic Exploration of the Human Interactome.''; Cell, 2015 PubMed Europe PMC Scholia
  2. Vo Nguyen TT, Watanabe Y, Shiba A, Noguchi M, Itoh S, Kato M; ''TMEPAI/PMEPA1 enhances tumorigenic activities in lung cancer cells.''; Cancer Sci, 2014 PubMed Europe PMC Scholia
  3. Mo S, Zhang L, Dai W, Han L, Wang R, Xiang W, Wang Z, Li Q, Yu J, Yuan J, Cai S, Cai G; ''Antisense lncRNA LDLRAD4-AS1 promotes metastasis by decreasing the expression of LDLRAD4 and predicts a poor prognosis in colorectal cancer.''; Cell Death Dis, 2020 PubMed Europe PMC Scholia
  4. Yrondi A, Fiori LM, Frey BN, Lam RW, MacQueen GM, Milev R, Müller DJ, Foster JA, Kennedy SH, Turecki G; ''Association Between Side Effects and Blood microRNA Expression Levels and Their Targeted Pathways in Patients With Major Depressive Disorder Treated by a Selective Serotonin Reuptake Inhibitor, Escitalopram: A CAN-BIND-1 Report.''; Int J Neuropsychopharmacol, 2020 PubMed Europe PMC Scholia
  5. Liu Z, Huo X, Zhao S, Yang J, Shi W, Jing L, Li W, Li Y, Ma L, Gao Y, Diao A; ''Low density lipoprotein receptor class A domain containing 4 (LDLRAD4) promotes tumorigenesis of hepatic cancer cells.''; Exp Cell Res, 2017 PubMed Europe PMC Scholia
  6. Wang IK, Sun KT, Tsai TH, Chen CW, Chang SS, Yu TM, Yen TH, Lin FY, Huang CC, Li CY; ''MiR-20a-5p mediates hypoxia-induced autophagy by targeting ATG16L1 in ischemic kidney injury.''; Life Sci, 2015 PubMed Europe PMC Scholia
  7. Nakano N, Maeyama K, Sakata N, Itoh F, Akatsu R, Nakata M, Katsu Y, Ikeno S, Togawa Y, Vo Nguyen TT, Watanabe Y, Kato M, Itoh S; ''C18 ORF1, a novel negative regulator of transforming growth factor-β signaling.''; J Biol Chem, 2014 PubMed Europe PMC Scholia
  8. Itoh S, Itoh F; ''TMEPAI family: involvement in regulation of multiple signalling pathways.''; J Biochem, 2018 PubMed Europe PMC Scholia
  9. Zarrei M, Burton CL, Engchuan W, Young EJ, Higginbotham EJ, MacDonald JR, Trost B, Chan AJS, Walker S, Lamoureux S, Heung T, Mojarad BA, Kellam B, Paton T, Faheem M, Miron K, Lu C, Wang T, Samler K, Wang X, Costain G, Hoang N, Pellecchia G, Wei J, Patel RV, Thiruvahindrapuram B, Roifman M, Merico D, Goodale T, Drmic I, Speevak M, Howe JL, Yuen RKC, Buchanan JA, Vorstman JAS, Marshall CR, Wintle RF, Rosenberg DR, Hanna GL, Woodbury-Smith M, Cytrynbaum C, Zwaigenbaum L, Elsabbagh M, Flanagan J, Fernandez BA, Carter MT, Szatmari P, Roberts W, Lerch J, Liu X, Nicolson R, Georgiades S, Weksberg R, Arnold PD, Bassett AS, Crosbie J, Schachar R, Stavropoulos DJ, Anagnostou E, Scherer SW; ''A large data resource of genomic copy number variation across neurodevelopmental disorders.''; NPJ Genom Med, 2019 PubMed Europe PMC Scholia
  10. Levy D, Ehret GB, Rice K, Verwoert GC, Launer LJ, Dehghan A, Glazer NL, Morrison AC, Johnson AD, Aspelund T, Aulchenko Y, Lumley T, Köttgen A, Vasan RS, Rivadeneira F, Eiriksdottir G, Guo X, Arking DE, Mitchell GF, Mattace-Raso FU, Smith AV, Taylor K, Scharpf RB, Hwang SJ, Sijbrands EJ, Bis J, Harris TB, Ganesh SK, O'Donnell CJ, Hofman A, Rotter JI, Coresh J, Benjamin EJ, Uitterlinden AG, Heiss G, Fox CS, Witteman JC, Boerwinkle E, Wang TJ, Gudnason V, Larson MG, Chakravarti A, Psaty BM, van Duijn CM; ''Genome-wide association study of blood pressure and hypertension.''; Nat Genet, 2009 PubMed Europe PMC Scholia


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124593view06:34, 13 November 2022EgonwBinding (is this the right way to model this?)
120598view21:34, 17 December 2021EweitzFix WP-PathVisio padding inconsistency with hsa-miR-20a-5p
120595view21:05, 17 December 2021EweitzRefine graphics, case
120594view20:57, 17 December 2021EweitzModified description
114084view08:07, 21 December 2020EgonwConverted three Labels to pathway DataNodes.
112888view13:14, 15 October 2020Fehrhartupdated miR nomenclature and WP style
110671view20:32, 27 May 2020EgonwMade the pathway clickable
110162view13:27, 22 April 2020EgonwModified title
110144view14:47, 20 April 2020EgonwFixed the miRNA identifer (HT Susan)
110143view11:13, 20 April 2020EgonwAdded an affinity study showing that NEDD4 and LDLRAD4 bind.
110142view11:03, 20 April 2020EgonwOntology Term : 'disease by infectious agent' added !
110141view11:03, 20 April 2020EgonwOntology Term : 'disease pathway' added !
110140view10:49, 20 April 2020EgonwAnother reference (but starting to think the left-hand complex may not actually be a complex).
110139view10:42, 20 April 2020EgonwAdded another reference. Many questions remain
110138view10:11, 20 April 2020EgonwFixed the data source (HT Freddie)
110137view10:08, 20 April 2020EgonwAdded another interesting lead, here for autophagosome formation.
110136view09:49, 20 April 2020EgonwAdded lncRNA silencing of LDLRAD4
110135view09:42, 20 April 2020EgonwAdded an link to blood pressure
110134view09:34, 20 April 2020EgonwAdded a paper that links LDLRAD4 to neurodevelopmental disorders.
110133view09:27, 20 April 2020EgonwMore detail
110132view09:14, 20 April 2020EgonwAdded a second reference.
110131view09:10, 20 April 2020EgonwCorrect pathway :(
110130view09:06, 20 April 2020EgonwAdded another conclusion of that paper.
110129view08:39, 20 April 2020EgonwFirst interaction found.
110127view07:48, 20 April 2020EgonwNew pathway

External references


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NameTypeDatabase referenceComment
ATG16L1GeneProductENSG00000085978 (Ensembl)
Autophagosome formationPathway
Blood pressurePathway
Ebola virus pathway in hostPathwayWP4217 (WikiPathways)
LDLRAD4-AS1RnaENSG00000267690 (Ensembl) lncRNA
LDLRAD4GeneProductENSG00000168675 (Ensembl) Also known as C18ORF1
NEDD4GeneProductENSG00000069869 (Ensembl)
Neurodevelopmental disordersPathway
PMEPA1GeneProductENSG00000124225 (Ensembl) Also known as TMEPAI
SMAD2GeneProductENSG00000175387 (Ensembl)
TGF-B signaling pathwayPathwayWP3874 (WikiPathways)
TGFBR1GeneProductENSG00000106799 (Ensembl)
TGFBR2GeneProductENSG00000163513 (Ensembl)
hsa-miR-20a-5pRnaMIMAT0000075 (miRBase mature sequence)

Annotated Interactions

No annotated interactions

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