Adverse outcome pathway for mitochondrial complex 1 (C1) inhibition (Homo sapiens)
From WikiPathways
Description
Adverse Outcome Pathway (AOP) network for mitochondrial Complex 1 (C1) inhibition leading to adverse outcomes in kidney, brain and liver.
Adverse Outcome Pathways (AOPs), in general, are defined as a sequence of key events that begins with a molecular initiating event (MIE) and leads to an Adverse Outcome. At that level, AOPs are described in the [AOPWiki](https://aopwiki.org/). This AOP network is based on 3 AOPs: [AOPwiki:3](https://aopwiki.org/aops/3), [AOPwiki:273](https://aopwiki.org/aops/273) and [AOPwiki:276](https://aopwiki.org/aops/276).
Quality Tags
Ontology Terms
Pathway Ontology : immune response pathway altered energy metabolic pathway
Disease : Fanconi-like syndrome Parkinson's disease
Bibliography
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History
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External references
DataNodes
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Name ![]() | Type ![]() | Database reference ![]() | Comment ![]() |
---|---|---|---|
Apoptosis | Pathway | WP1772 (WikiPathways) ![]() | |
Autophagy | Pathway | WP4923 (WikiPathways) ![]() | |
Decreased mitochondrial oxidative phosphorylation | Pathway | WP111 (WikiPathways) ![]() | |
Decreased proximal tubule vectorial transport | Pathway | WP4917 (WikiPathways) ![]() | |
Degeneration of DA neurons of nigrostratial pathway | Pathway | WP2855 (WikiPathways) ![]() | |
Deguelin | Metabolite | CHEBI:4357 (ChEBI) ![]() | |
Ferroptosis | Pathway | WP4313 (WikiPathways) ![]() | |
Impaired proteostasis | Pathway | WP4918 (WikiPathways) ![]() | |
Increased ROS | Pathway | WP3941 (WikiPathways) ![]() | |
Inhibition of mitochondrial Complex I | Pathway | WP4324 (WikiPathways) ![]() | |
Necrosis | Pathway | WP5022 (WikiPathways) ![]() | |
Neuroinflammation | Pathway | WP4919 (WikiPathways) ![]() | |
Parkinsonian motor deficits | Pathway | WP2371 (WikiPathways) ![]() | |
Rotenone | Metabolite | CHEBI:28201 (ChEBI) ![]() | |
UPR | Pathway | WP4925 (WikiPathways) ![]() |
Annotated Interactions
No annotated interactions