Adverse outcome pathway for mitochondrial complex 1 (C1) inhibition (Homo sapiens)
From WikiPathways
Description
Adverse Outcome Pathway (AOP) network for mitochondrial Complex 1 (C1) inhibition leading to adverse outcomes in kidney, brain and liver.
Adverse Outcome Pathways (AOPs), in general, are defined as a sequence of key events that begins with a molecular initiating event (MIE) and leads to an Adverse Outcome. At that level, AOPs are described in the [AOPWiki](https://aopwiki.org/). This AOP network is based on 3 AOPs: [AOPwiki:3](https://aopwiki.org/aops/3), [AOPwiki:273](https://aopwiki.org/aops/273) and [AOPwiki:276](https://aopwiki.org/aops/276).
Quality Tags
Ontology Terms
Saving...Bibliography
No bibliography
History
View all... |
External references
DataNodes
| View all... |
Name  | Type | Database reference | Comment |
|---|---|---|---|
| Apoptosis | Pathway | WP1772 (WikiPathways)  | |
| Autophagy | Pathway | WP4923 (WikiPathways) | |
| Decreased mitochondrial oxidative phosphorylation | Pathway | WP111 (WikiPathways) | |
| Decreased proximal tubule vectorial transport | Pathway | WP4917 (WikiPathways) | |
| Degeneration of DA neurons of nigrostratial pathway | Pathway | WP2855 (WikiPathways) | |
| Deguelin | Metabolite | CHEBI:4357 (ChEBI) | |
| Ferroptosis | Pathway | WP4313 (WikiPathways) | |
| Impaired proteostasis | Pathway | WP4918 (WikiPathways) | |
| Increased ROS | Pathway | WP3941 (WikiPathways) | |
| Inhibition of mitochondrial Complex I | Pathway | WP4324 (WikiPathways) | |
| Necrosis | Pathway | WP5022 (WikiPathways) | |
| Neuroinflammation | Pathway | WP4919 (WikiPathways) | |
| Parkinsonian motor deficits | Pathway | WP2371 (WikiPathways) | |
| Rotenone | Metabolite | CHEBI:28201 (ChEBI) | |
| UPR | Pathway | WP4925 (WikiPathways) |
Annotated Interactions
No annotated interactions
