Adverse outcome pathway for mitochondrial complex 1 (C1) inhibition (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Liver injuryBrain injuryKidney injuryKidneyChemical induced Fanconi syndromeLiverBrainCell deathAutophagyNecrosisApoptosisFerroptosisDecreased Na/K ATPase activityMitochondrial dysfunctionDecreased mitochondrial oxidative phosphorylationDegeneration of DA neurons of nigrostratial pathwayDeguelinDecreased proximal tubule vectorial transportParkinsonian motor deficitsNeuroinflammationInhibition of mitochondrial Complex IIncreased ROSImpaired proteostasisUPRRotenoneName: Adverse outcome pathway for mitochondrial complex 1 (C1) inhibitionOrganism: Homo sapiens


Description

Adverse Outcome Pathway (AOP) network for mitochondrial Complex 1 (C1) inhibition leading to adverse outcomes in kidney, brain and liver. Adverse Outcome Pathways (AOPs), in general, are defined as a sequence of key events that begins with a molecular initiating event (MIE) and leads to an Adverse Outcome. At that level, AOPs are described in the [AOPWiki](https://aopwiki.org/). This AOP network is based on 3 AOPs: [AOPwiki:3](https://aopwiki.org/aops/3), [AOPwiki:273](https://aopwiki.org/aops/273) and [AOPwiki:276](https://aopwiki.org/aops/276).

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Quality Tags

Image:NeedsWork.pngNeeds work
Image:NeedsRef.pngAdd references
Image:Wplogo_31.pngCommunity: Adverse Outcome Pathways
Image:Curated.pngApproved version

Ontology Terms

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
137835
Approved
view13:48, 8 March 2025EweitzRefine padding
137834view13:47, 8 March 2025EweitzEconomize layout
137793view06:26, 8 March 2025EgonwModified description
116532
AOP
view11:59, 7 May 2021EweitzModified title
115242view17:13, 7 February 2021EgonwReplaced a link to a deleted pathway to another pathway about necrosis
111416view10:33, 7 August 2020Marvin M2Modified description
111407view16:10, 6 August 2020EveloModified description
111406view16:09, 6 August 2020EveloModified description
111405view16:05, 6 August 2020EveloModified description
111404view16:04, 6 August 2020EveloModified description
111403view15:51, 6 August 2020EveloOntology Term : 'Parkinson's disease' added !
111402view15:43, 6 August 2020EveloModified description
111401view15:43, 6 August 2020EveloOntology Term : 'Fanconi-like syndrome' added !
111400view15:42, 6 August 2020EveloOntology Term : 'altered energy metabolic pathway' added !
111399view15:39, 6 August 2020EveloModified title
110993view17:50, 25 June 2020Marvin M2Modified title
110831view12:58, 11 June 2020AnnabayaEdit pathway node shapes
110381view15:34, 8 May 2020AnnabayaOntology Term : 'immune response pathway' added !
110378view15:29, 8 May 2020AnnabayaAdd pathway identifiers
110314view22:12, 3 May 2020Marvin M2Connected unconnected lines
110303view06:37, 3 May 2020EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
110271view13:53, 1 May 2020AnnabayaModified title
110270view13:51, 1 May 2020AnnabayaNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ApoptosisPathwayWP1772 (WikiPathways)
AutophagyPathwayWP4923 (WikiPathways)
Decreased mitochondrial oxidative phosphorylationPathwayWP111 (WikiPathways)
Decreased proximal tubule vectorial transportPathwayWP4917 (WikiPathways)
Degeneration of DA neurons of nigrostratial pathwayPathwayWP2855 (WikiPathways)
DeguelinMetaboliteCHEBI:4357 (ChEBI)
FerroptosisPathwayWP4313 (WikiPathways)
Impaired proteostasisPathwayWP4918 (WikiPathways)
Increased ROSPathwayWP3941 (WikiPathways)
Inhibition of mitochondrial Complex IPathwayWP4324 (WikiPathways)
NecrosisPathwayWP5022 (WikiPathways)
NeuroinflammationPathwayWP4919 (WikiPathways)
Parkinsonian motor deficitsPathwayWP2371 (WikiPathways)
RotenoneMetaboliteCHEBI:28201 (ChEBI)
UPRPathwayWP4925 (WikiPathways)

Annotated Interactions

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