Proximal tubule transport (Homo sapiens)

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28Phosphate reabsorption3CFEXV-type H+-ATPaseNHE39, 12Apical sideAmino acid transport1Organic anion secretionBasolateral sideSLC47A2ABCG2SLC7A8SLC47A1Cysorganic anionorganic cationATP6V0D2ATP6V0E1SLC22A2SLC7A9SLC5A2ProATP1B1CA4SLC34A15ATP6V1Doxalate(2−)SLC1A1SLC5A8SLC6A206SLC4A4formate11ATP6V1HSLC12A410ATP6V0A4I-LactateNa+ATP6V1ASLC22A11SLC3A2TMEM27ATP6V0BurateSLC16A10SLC2A1ATP6V1G1SLC34A3GlyABCC4ATP1A1AlaSLC9A3HPO4 2-ABCB1SLC5A5FXYD24SLC7A7SLC6A19OH-ATP6V1FCationic amino acidsAmino acidsATP6V1B1SLC4A2SLC36A211ABCC2ATP6V1C1SLC6A18SLC2A2ATP6V1E1SLC26A67sulfateSLC20A2ATP6V0CSLC3A1hydrogencarbonateAQP1α-ketoglutarateK+Na+K+Na+Na+Na+Na+H+H+Cl-hydrogencarbonateCl-H+H+H2CO3H2OCO2H+CA25H2OCO2HCO3-H+Na+Na+HCO3-AQP1H2OCO2Na+Na+GlucoseGlucoseGlucoseI-Na+Na+Na+Na+LactateSLC3A2TMEM27TMEM27H+H+Na+Na+Na+K+ProCationic amino acidsNa+Anionic amino acidsH+Na+K+H+Na+ProNa+Na+Na+Na+CysNa+Na+Na+Na+Na+Na+H2PO4-H+HPO4 2-HPO4 2-H2PO4 -Cl-Cl-OH-hydrogencarbonateformateoxalate(2−)Amino acidsCationic amino acidsAmino acidsAmino acidsAmino acidsAmino acidsProGlyAlaAnionic amino acidsAmino acidsAmino acidsAmino acidsAmino acidsAmino acidsAmino acidsCationic amino acidssulfateSLC5A1Na+Na+GlucoseGlucoseGlucoseCl-Cl-K+K+α-ketoglutarateα-ketoglutarateα-ketoglutarateorganic anionorganic anionα-ketoglutarateα-ketoglutarateorganic anionorganic anionorganic anionα-ketoglutarateα-ketoglutarateNa+Na+SLC22A7SLC22A6SLC22A8SLC13A3organic anionorganic anionorganic anionorganic anionorganic anionorganic anionα-ketoglutarateα-ketoglutarateurateorganic cationorganic cationorganic cationorganic cationorganic cationorganic cationorganic cationH+H+H+H+Organic cation secretion


Description

This pathway provides an overview of all active transport that occurs in the proximal tubule of the nephron in the kidneys. The proximal tubule plays roles in regulating the pH of the filtrate, secreting organic waste, and reabsorption of NaCl, a large variety of solutes, and amino acids from the filtrate back into the circulation. The apical side indicates the proximal tubule which contains the filtrate after passing through Bowman's capsule, which later becomes the urine after passing through the complete nephron, from which solutes are reabsorbed (taken back into the body) and into which waste is secreted. Impaired ability of reabsorption by the proximal tubule can lead to Fanconi syndrome.

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Ontology Terms

 

Bibliography

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  1. Verrey F, Singer D, Ramadan T, Vuille-dit-Bille RN, Mariotta L, Camargo SM; ''Kidney amino acid transport.''; Pflugers Arch, 2009 PubMed Europe PMC Scholia
  2. Koeppen, B. M., Stanton, B. A.; ''Renal physiology (6th ed., Ser. Mosby physiology series)''; Elsevier, 2019
  3. Curthoys NP, Moe OW; ''Proximal tubule function and response to acidosis.''; Clin J Am Soc Nephrol, 2014 PubMed Europe PMC Scholia
  4. Portulano C, Paroder-Belenitsky M, Carrasco N; ''The Na+/I- symporter (NIS): mechanism and medical impact.''; Endocr Rev, 2014 PubMed Europe PMC Scholia
  5. Purkerson JM, Schwartz GJ; ''The role of carbonic anhydrases in renal physiology.''; Kidney Int, 2007 PubMed Europe PMC Scholia
  6. Gopal E, Fei YJ, Sugawara M, Miyauchi S, Zhuang L, Martin P, Smith SB, Prasad PD, Ganapathy V; ''Expression of slc5a8 in kidney and its role in Na(+)-coupled transport of lactate.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  7. Aronson PS; ''Essential roles of CFEX-mediated Cl(-)-oxalate exchange in proximal tubule NaCl transport and prevention of urolithiasis.''; Kidney Int, 2006 PubMed Europe PMC Scholia
  8. Clausen MV, Hilbers F, Poulsen H; ''The Structure and Function of the Na,K-ATPase Isoforms in Health and Disease.''; Front Physiol, 2017 PubMed Europe PMC Scholia
  9. Sarkar J, Wen X, Simanian EJ, Paine ML; ''V-type ATPase proton pump expression during enamel formation.''; Matrix Biol, 2016 PubMed Europe PMC Scholia
  10. Liapis H, Nag M, Kaji DM; ''K-Cl cotransporter expression in the human kidney.''; Am J Physiol, 1998 PubMed Europe PMC Scholia
  11. Skelton LA, Boron WF, Zhou Y; ''Acid-base transport by the renal proximal tubule.''; J Nephrol, 2010 PubMed Europe PMC Scholia
  12. Wagner CA, Finberg KE, Breton S, Marshansky V, Brown D, Geibel JP; ''Renal vacuolar H+-ATPase.''; Physiol Rev, 2004 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
119111view13:24, 17 June 2021FinterlyAdded ISBN for book citation
110974view14:01, 25 June 2020Fehrhartchanged MIM conversion to graphical line
110418view14:46, 9 May 2020Marvin M2Modified description
110417view14:42, 9 May 2020Marvin M2Connected unconnected lines
110405view03:02, 9 May 2020Marvin M2Modified description
110404view03:02, 9 May 2020Marvin M2Ontology Term : 'Fanconi syndrome' added !
110403view02:56, 9 May 2020Marvin M2Ontology Term : 'transport pathway' added !
110402view02:52, 9 May 2020Marvin M2Ontology Term : 'epithelial cell of proximal tubule' added !
110401view02:41, 9 May 2020Marvin M2Modified description
110400view02:28, 9 May 2020Marvin M2completed pathway figure
110368view15:13, 8 May 2020AnnabayaAdd amino acid transport and V-type H+-ATPase
110339view02:12, 7 May 2020Marvin M2New pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABCB1GeneProductENSG00000085563 (Ensembl)
ABCC2GeneProductENSG00000023839 (Ensembl)
ABCC4GeneProductENSG00000125257 (Ensembl)
ABCG2GeneProductENSG00000118777 (Ensembl)
AQP1GeneProductENSG00000240583 (Ensembl)
ATP1A1GeneProductENSG00000163399 (Ensembl)
ATP1B1GeneProductENSG00000143153 (Ensembl)
ATP6V0A4GeneProductENSG00000105929 (Ensembl)
ATP6V0BGeneProductENSG00000117410 (Ensembl)
ATP6V0CGeneProductENSG00000185883 (Ensembl)
ATP6V0D2GeneProductENSG00000147614 (Ensembl)
ATP6V0E1GeneProductENSG00000113732 (Ensembl)
ATP6V1AGeneProductENSG00000114573 (Ensembl)
ATP6V1B1GeneProductENSG00000116039 (Ensembl)
ATP6V1C1GeneProductENSG00000155097 (Ensembl)
ATP6V1DGeneProductENSG00000100554 (Ensembl)
ATP6V1E1GeneProductENSG00000131100 (Ensembl)
ATP6V1FGeneProductENSG00000128524 (Ensembl)
ATP6V1G1GeneProductENSG00000136888 (Ensembl)
ATP6V1HGeneProductENSG00000047249 (Ensembl)
AlaMetabolite16449 (ChEBI)
Amino acidsMetabolite33709 (ChEBI)
Anionic amino acidsMetaboliteCHEBI:64898 (ChEBI)
CA2GeneProductENSG00000104267 (Ensembl)
CA4GeneProductENSG00000167434 (Ensembl)
CO2Metabolite16526 (ChEBI)
Cationic amino acidsMetaboliteCHEBI:58942 (ChEBI)
Cl-Metabolite17996 (ChEBI)
CysMetabolite17376 (ChEBI)
FXYD2GeneProductENSG00000137731 (Ensembl)
GlucoseMetabolite17234 (ChEBI)
GlyMetabolite15428 (ChEBI)
H+MetaboliteCHEBI:15378 (ChEBI)
H2CO3Metabolite28976 (ChEBI)
H2OMetabolite15377 (ChEBI)
H2PO4 -Metabolite39745 (ChEBI)
H2PO4-Metabolite39745 (ChEBI)
HCO3-Metabolite17544 (ChEBI)
HPO4 2-Metabolite43474 (ChEBI)
I-Metabolite16382 (ChEBI)
K+Metabolite29103 (ChEBI)
LactateMetabolite24996 (ChEBI)
Na+Metabolite29101 (ChEBI)
OH-Metabolite16234 (ChEBI)
ProMetabolite26271 (ChEBI)
SLC12A4GeneProductENSG00000124067 (Ensembl)
SLC13A3GeneProductENSG00000158296 (Ensembl)
SLC16A10GeneProductENSG00000112394 (Ensembl)
SLC1A1GeneProductENSG00000106688 (Ensembl)
SLC20A2GeneProductENSG00000168575 (Ensembl)
SLC22A11GeneProductENSG00000168065 (Ensembl)
SLC22A2GeneProductENSG00000112499 (Ensembl)
SLC22A6GeneProductENSG00000197901 (Ensembl)
SLC22A7GeneProductENSG00000137204 (Ensembl)
SLC22A8GeneProductENSG00000149452 (Ensembl)
SLC26A6GeneProductENSG00000225697 (Ensembl)
SLC2A1GeneProductENSG00000117394 (Ensembl)
SLC2A2GeneProductENSG00000163581 (Ensembl)
SLC34A1GeneProductENSG00000131183 (Ensembl)
SLC34A3GeneProductENSG00000198569 (Ensembl)
SLC36A2GeneProductENSG00000186335 (Ensembl)
SLC3A1GeneProductENSG00000138079 (Ensembl)
SLC3A2GeneProductENSG00000168003 (Ensembl)
SLC47A1GeneProductENSG00000142494 (Ensembl)
SLC47A2GeneProductENSG00000180638 (Ensembl)
SLC4A2GeneProductENSG00000164889 (Ensembl)
SLC4A4GeneProductENSG00000080493 (Ensembl)
SLC5A1GeneProductENSG00000100170 (Ensembl)
SLC5A2GeneProductENSG00000140675 (Ensembl)
SLC5A5GeneProductENSG00000105641 (Ensembl)
SLC5A8GeneProductENSG00000256870 (Ensembl)
SLC6A18GeneProductENSG00000164363 (Ensembl)
SLC6A19GeneProductENSG00000174358 (Ensembl)
SLC6A20GeneProductENSG00000163817 (Ensembl)
SLC7A7GeneProductENSG00000155465 (Ensembl)
SLC7A8GeneProductENSG00000092068 (Ensembl)
SLC7A9GeneProductENSG00000021488 (Ensembl)
SLC9A3GeneProductENSG00000066230 (Ensembl)
TMEM27GeneProductENSG00000147003 (Ensembl)
formateMetabolite15740 (ChEBI)
hydrogencarbonateMetabolite17544 (ChEBI)
organic anionMetabolite25696 (ChEBI)
organic cationMetaboliteCHEBI:25697 (ChEBI)
oxalate(2−)Metabolite30623 (ChEBI)
sulfateMetabolite16189 (ChEBI)
urateMetabolite46818 (ChEBI)
α-ketoglutarateMetabolite16810 (ChEBI)

Annotated Interactions

No annotated interactions

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