MAPK pathway in congenital thyroid cancer (Homo sapiens)

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14, 18, 1942, 25, 3024, 28KSR124NucleusCytoplasmMAP2K23, 1912, 1914, 19, 284, 1214, 19, 289, 12, 1920, 2323, 2814, 1914, 193, 1923, 28ELK1c-FOSc-MYCc-JUNCRAFRASGTP1, 5, 7, 10-13, 15...MAP2K1SOS218MAPK31918, 20ALK tyrosine kinase receptor3, 6, 8, 17, 19GDPMAPK3SHC118, 203BRAF18, 20-22, 28...SOS1GRB2193


Description

The MAPK pathway involved in the progression of different diseases such as diabetes, developmental abnormalities and cancer since it has a essential role in the regulation a wide variety of cellular processes such as proliferation, differentiation and apoptosis. consequently, dysregulation of MAPK pathway leads to the occurrence of the related disease

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Bibliography

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  16. Gupta S, Ramjaun AR, Haiko P, Wang Y, Warne PH, Nicke B, Nye E, Stamp G, Alitalo K, Downward J; ''Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice.''; Cell, 2007 PubMed Europe PMC Scholia
  17. Stoica GE, Kuo A, Aigner A, Sunitha I, Souttou B, Malerczyk C, Caughey DJ, Wen D, Karavanov A, Riegel AT, Wellstein A; ''Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
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  21. Melo M, Gaspar da Rocha A, Batista R, Vinagre J, Martins MJ, Costa G, Ribeiro C, Carrilho F, Leite V, Lobo C, Cameselle-Teijeiro JM, Cavadas B, Pereira L, Sobrinho-Simões M, Soares P; ''TERT, BRAF, and NRAS in Primary Thyroid Cancer and Metastatic Disease.''; J Clin Endocrinol Metab, 2017 PubMed Europe PMC Scholia
  22. Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE, Fagin JA; ''High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.''; Cancer Res, 2003 PubMed Europe PMC Scholia
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  24. Lavoie H, Sahmi M, Maisonneuve P, Marullo SA, Thevakumaran N, Jin T, Kurinov I, Sicheri F, Therrien M; ''MEK drives BRAF activation through allosteric control of KSR proteins.''; Nature, 2018 PubMed Europe PMC Scholia
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  29. Landa I, Ibrahimpasic T, Boucai L, Sinha R, Knauf JA, Shah RH, Dogan S, Ricarte-Filho JC, Krishnamoorthy GP, Xu B, Schultz N, Berger MF, Sander C, Taylor BS, Ghossein R, Ganly I, Fagin JA; ''Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers.''; J Clin Invest, 2016 PubMed Europe PMC Scholia
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  32. Nikiforova MN, Kimura ET, Gandhi M, Biddinger PW, Knauf JA, Basolo F, Zhu Z, Giannini R, Salvatore G, Fusco A, Santoro M, Fagin JA, Nikiforov YE; ''BRAF mutations in thyroid tumors are restricted to papillary carcinomas and anaplastic or poorly differentiated carcinomas arising from papillary carcinomas.''; J Clin Endocrinol Metab, 2003 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
120795view20:56, 8 January 2022AlexanderPicoReverted to version '17:17, 22 December 2021' by AlexanderPico
120794view20:56, 8 January 2022AlexanderPicoReverted to version '22:59, 29 June 2020' by AlexanderPico
120666view00:17, 23 December 2021EweitzOntology Term : 'PW:0000001' removed !
111017view05:59, 30 June 2020FehrhartOntology Term : 'thyroid cancer' added !
111016view05:58, 30 June 2020FehrhartOntology Term : 'thyroid cancer pathway' added !
111015view05:58, 30 June 2020FehrhartOntology Term : 'altered Erk5 MAPK signaling pathway' added !
111014view05:57, 30 June 2020FehrhartOntology Term : 'Pathway Ontology' added !
111007view06:16, 29 June 2020FehrhartModified title
111002view17:42, 26 June 2020Omranhasanrename Nucleus
110897view11:21, 18 June 2020OmranhasanModified description
110880view11:38, 17 June 2020OmranhasanAdd a KSR1 scaffolding protein with references
110838view09:15, 12 June 2020Omranhasanvisualization
110833view22:19, 11 June 2020Omranhasanadding annotation to the pathway components add visualization
110826view11:19, 10 June 2020Omranhasan_ redrawing the (GDP=>GTP) interaction _adding references to the interactions
110778view11:18, 4 June 2020Omranhasanconnecting nodes
110777view09:23, 4 June 2020Omranhasanconnecting tyrosine kinase receptor to the the adopter proteins ( GRB2,SHC1)
110771view20:56, 3 June 2020EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
110769view13:16, 3 June 2020Omranhasantest
110680view11:18, 28 May 2020Fehrharttest2
110679view11:15, 28 May 2020Fehrharttest
110678view11:14, 28 May 2020Fehrhartconnected a line for test
110520view06:48, 17 May 2020EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
110505view11:53, 15 May 2020OmranhasanNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment

RAS

ProteinENSG00000133703 (Ensembl) RAS protein has three isoforms ( K,N and H RAS). the isoforms differ in ability of activating RAF protein, the isoform which is responsable the most of activating of Raf protein is Kras> also, HRAS has the ability of activating the RAF proteins but less efficiently than KRAS. (PMID: 9727023)
ALK tyrosine kinase receptorProteinQ9UM73 (Uniprot-TrEMBL)
BRAFGeneProductENSG00000157764 (Ensembl)
CRAF GeneProductENSG00000132155 (Ensembl)
ELK1GeneProductENSG00000126767 (Ensembl)
GDPMetaboliteCHEBI:17552 (ChEBI)
GRB2ProteinQ75VX8 (Uniprot-TrEMBL)
GTPMetaboliteCHEBI:15996 (ChEBI)
KSR1GeneProductENSG00000141068 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAPK3 GeneProductENSG00000102882 (Ensembl) Also known as ERK
MAPK3GeneProductENSG00000102882 (Ensembl)
  • Also known as ERK
  • Type your comment here
SHC1GeneProductENSG00000160691 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProductENSG00000100485 (Ensembl)
c-FOSGeneProductENSG00000170345 (Ensembl)
c-JUNGeneProductENSG00000177606 (Ensembl)
c-MYCGeneProductENSG00000136997 (Ensembl)

Annotated Interactions

No annotated interactions

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