MAPK pathway in congenital thyroid cancer (Homo sapiens)

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3, 4, 15120, 21, 2913, 31KSR113NucleusCytoplasmMAP2K23, 163, 113, 15, 311, 113, 15, 313, 11, 1822, 2727, 313, 153, 153, 1627, 31ELK1FOSMYCJUNCRAFRASGTP6, 8-12, 14...MAP2K1SOS24MAPK334, 22ALK3, 5, 16, 28, 30GDPMAPK3SHC14, 2216BRAF2, 4, 7, 22, 25...SOS1GRB2316


Description

The MAPK pathway involved in the progression of different diseases such as diabetes, developmental abnormalities and cancer since it has a essential role in the regulation a wide variety of cellular processes such as proliferation, differentiation and apoptosis. consequently, dysregulation of MAPK pathway leads to the occurrence of the related disease

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Bibliography

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  1. Bos JL, Rehmann H, Wittinghofer A; ''GEFs and GAPs: critical elements in the control of small G proteins.''; Cell, 2007 PubMed Europe PMC Scholia
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  9. Saavedra HI, Knauf JA, Shirokawa JM, Wang J, Ouyang B, Elisei R, Stambrook PJ, Fagin JA; ''The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway.''; Oncogene, 2000 PubMed Europe PMC Scholia
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  13. Lavoie H, Sahmi M, Maisonneuve P, Marullo SA, Thevakumaran N, Jin T, Kurinov I, Sicheri F, Therrien M; ''MEK drives BRAF activation through allosteric control of KSR proteins.''; Nature, 2018 PubMed Europe PMC Scholia
  14. Vitagliano D, Portella G, Troncone G, Francione A, Rossi C, Bruno A, Giorgini A, Coluzzi S, Nappi TC, Rothstein JL, Pasquinelli R, Chiappetta G, Terracciano D, Macchia V, Melillo RM, Fusco A, Santoro M; ''Thyroid targeting of the N-ras(Gln61Lys) oncogene in transgenic mice results in follicular tumors that progress to poorly differentiated carcinomas.''; Oncogene, 2006 PubMed Europe PMC Scholia
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  23. Landa I, Ibrahimpasic T, Boucai L, Sinha R, Knauf JA, Shah RH, Dogan S, Ricarte-Filho JC, Krishnamoorthy GP, Xu B, Schultz N, Berger MF, Sander C, Taylor BS, Ghossein R, Ganly I, Fagin JA; ''Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers.''; J Clin Invest, 2016 PubMed Europe PMC Scholia
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  31. Lavoie H, Therrien M; ''Regulation of RAF protein kinases in ERK signalling.''; Nat Rev Mol Cell Biol, 2015 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
134862view20:13, 27 July 2024EweitzUse gene symbols
134861view20:10, 27 July 2024EweitzStandardize metabolite color, refine alignment
134860view20:09, 27 July 2024EweitzEconomize layout
134855view19:56, 27 July 2024EweitzFix truncated text, economize layout
134356view05:45, 21 July 2024EgonwRemoved a template comment
120795view20:56, 8 January 2022AlexanderPicoReverted to version '17:17, 22 December 2021' by AlexanderPico
120794view20:56, 8 January 2022AlexanderPicoReverted to version '22:59, 29 June 2020' by AlexanderPico
120666view00:17, 23 December 2021EweitzOntology Term : 'PW:0000001' removed !
111017view05:59, 30 June 2020FehrhartOntology Term : 'thyroid cancer' added !
111016view05:58, 30 June 2020FehrhartOntology Term : 'thyroid cancer pathway' added !
111015view05:58, 30 June 2020FehrhartOntology Term : 'altered Erk5 MAPK signaling pathway' added !
111014view05:57, 30 June 2020FehrhartOntology Term : 'Pathway Ontology' added !
111007view06:16, 29 June 2020FehrhartModified title
111002view17:42, 26 June 2020Omranhasanrename Nucleus
110897view11:21, 18 June 2020OmranhasanModified description
110880view11:38, 17 June 2020OmranhasanAdd a KSR1 scaffolding protein with references
110838view09:15, 12 June 2020Omranhasanvisualization
110833view22:19, 11 June 2020Omranhasanadding annotation to the pathway components add visualization
110826view11:19, 10 June 2020Omranhasan_ redrawing the (GDP=>GTP) interaction _adding references to the interactions
110778view11:18, 4 June 2020Omranhasanconnecting nodes
110777view09:23, 4 June 2020Omranhasanconnecting tyrosine kinase receptor to the the adopter proteins ( GRB2,SHC1)
110771view20:56, 3 June 2020EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
110769view13:16, 3 June 2020Omranhasantest
110680view11:18, 28 May 2020Fehrharttest2
110679view11:15, 28 May 2020Fehrharttest
110678view11:14, 28 May 2020Fehrhartconnected a line for test
110520view06:48, 17 May 2020EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
110505view11:53, 15 May 2020OmranhasanNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment

RAS

ProteinENSG00000133703 (Ensembl) RAS protein has three isoforms ( K,N and H RAS). the isoforms differ in ability of activating RAF protein, the isoform which is responsable the most of activating of Raf protein is Kras> also, HRAS has the ability of activating the RAF proteins but less efficiently than KRAS. (PMID: 9727023)
ALKProteinQ9UM73 (Uniprot-TrEMBL)
BRAFGeneProductENSG00000157764 (Ensembl)
CRAF GeneProductENSG00000132155 (Ensembl)
ELK1GeneProductENSG00000126767 (Ensembl)
FOSGeneProductENSG00000170345 (Ensembl) c-FOS
GDPMetaboliteCHEBI:17552 (ChEBI)
GRB2ProteinQ75VX8 (Uniprot-TrEMBL)
GTPMetaboliteCHEBI:15996 (ChEBI)
JUNGeneProductENSG00000177606 (Ensembl)
KSR1GeneProductENSG00000141068 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAPK3 GeneProductENSG00000102882 (Ensembl) Also known as ERK
MAPK3GeneProductENSG00000102882 (Ensembl) Also known as ERK
MYCGeneProductENSG00000136997 (Ensembl)
SHC1GeneProductENSG00000160691 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProductENSG00000100485 (Ensembl)

Annotated Interactions

No annotated interactions

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