Direct reversal repair (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Damaged base with CH2OH group5'5'3'3'MGMTALKBH2ALKBH35'5'3'3'Damaged base with CH3 group5'5'3'3'Native DNAName: Direct reversal repairOrganism: Homo sapiens


Description

Direct reversal repair is a mechanism of repair where the damaged area or lesion is repaired directly by specialized proteins. It does not involve breakage of the phosphodiester backbone and doesn't require a reference template unlike the other single-strand repair mechanism. Methylation of guanine bases is directly reversed by the protein methyl guanine methyl transferase (MGMT). This is an expensive process because each MGMT molecule can be used only once. Methylation of the bases cytosine and adenine is repaired by ALKBH2 and ALKBH3. This pathway is based on information from REPAIRtoire (https://repairtoire.genesilico.pl/Pathway/13/) and Wikipedia (https://en.wikipedia.org/wiki/DNA_repair).

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Quality Tags

Image:Curated.pngApproved version
Image:NeedsRef.pngAdd references
Image:Wplogo_31.pngCommunity: CPTAC

Ontology Terms

 

Bibliography

  1. ''Direct reversal repair''; REPAIRtoire,

History

View all...
CompareRevisionActionTimeUserComment
136381
Approved
CPTAC
view01:24, 1 February 2025KhanspersModified description
136380view01:23, 1 February 2025Khanspersupdated reference
136379view01:22, 1 February 2025KhanspersOntology Term : 'regulatory pathway' added !
136378view01:21, 1 February 2025Khanspersupdated color on object
136377view01:20, 1 February 2025Khanspersadded reference, added labels to groups
117699view12:21, 22 May 2021EweitzModified title
110595view06:09, 20 May 2020KhanspersOntology Term : 'DNA repair pathway' added !
110594view05:55, 20 May 2020KhanspersModified description
110593view05:39, 20 May 2020Khanspersdecreased board height
110592view05:39, 20 May 2020Khanspersdecreased board height
110591view05:38, 20 May 2020KhanspersNew pathway

External references

DataNodes

Name  ↓Type  ↓Database reference  ↓Comment  ↓
ALKBH2GeneProductENSG00000189046 (Ensembl)
ALKBH3GeneProductENSG00000166199 (Ensembl)
MGMTGeneProductENSG00000170430 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP4931"
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