GPR143 in melanocytes and retinal pigment epithelium cells (Homo sapiens)

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51113, 15, 16151128, 143, 7114152, 910410, 16158, 14166156, 9151521512221115TYRMLANAGNAQADCY2GNASPRKACGTYRP1PLCB3ATPDAGPMELPPiARRB2L-DOPADCTGPR143DCTcAMPTYRP1TYRCREB1ASIPARRB1PRKCBMITFGNA15SERPINF1IQDopamineADCY4GPR143PRKACBADCY9PMELPLCB4Ca2+PLCB1PRKACAITPR1PLCB2POMCVEGFAL-tyrosineDHICAMC1RIP3DQDopachrome11DHI15MART-1MITFCREB1


Description

A model demonstrating the place of the GPR143 gene in the pathogenesis of ocular albinism type 1. The latter shows the interactions between GPR143 and the different genes responsible for melanogenesis as well as growth factors such as SERPINF1 and VEGF in melanocytes or the retinal pigment epithelium.

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Ontology Terms

 

Bibliography

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  1. ''''; , PubMed Europe PMC Scholia
  2. Innamorati G, Piccirillo R, Bagnato P, Palmisano I, Schiaffino MV; ''The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor.''; Pigment Cell Res, 2006 PubMed Europe PMC Scholia
  3. McKay BS; ''Pigmentation and vision: Is GPR143 in control?''; J Neurosci Res, 2019 PubMed Europe PMC Scholia
  4. Gonzalez GA, Montminy MR; ''Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133.''; Cell, 1989 PubMed Europe PMC Scholia
  5. Hoashi T, Watabe H, Muller J, Yamaguchi Y, Vieira WD, Hearing VJ; ''MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  6. Lopez VM, Decatur CL, Stamer WD, Lynch RM, McKay BS; ''L-DOPA is an endogenous ligand for OA1.''; PLoS Biol, 2008 PubMed Europe PMC Scholia
  7. Figueroa AG, McKay BS; ''A G-Protein Coupled Receptor and Macular Degeneration.''; Cells, 2020 PubMed Europe PMC Scholia
  8. Wilson BD, Ollmann MM, Kang L, Stoffel M, Bell GI, Barsh GS; ''Structure and function of ASP, the human homolog of the mouse agouti gene.''; Hum Mol Genet, 1995 PubMed Europe PMC Scholia
  9. ''''; , PubMed Europe PMC Scholia
  10. De Filippo E, Schiedel AC, Manga P; ''Interaction between G Protein-Coupled Receptor 143 and Tyrosinase: Implications for Understanding Ocular Albinism Type 1.''; J Invest Dermatol, 2017 PubMed Europe PMC Scholia
  11. D'Mello SA, Finlay GJ, Baguley BC, Askarian-Amiri ME; ''Signaling Pathways in Melanogenesis.''; Int J Mol Sci, 2016 PubMed Europe PMC Scholia
  12. Giordano F, Bonetti C, Surace EM, Marigo V, Raposo G; ''The ocular albinism type 1 (OA1) G-protein-coupled receptor functions with MART-1 at early stages of melanogenesis to control melanosome identity and composition.''; Hum Mol Genet, 2009 PubMed Europe PMC Scholia
  13. Möller K, Sigurbjornsdottir S, Arnthorsson AO, Pogenberg V, Dilshat R, Fock V, Brynjolfsdottir SH, Bindesboll C, Bessadottir M, Ogmundsdottir HM, Simonsen A, Larue L, Wilmanns M, Thorsson V, Steingrimsson E, Ogmundsdottir MH; ''MITF has a central role in regulating starvation-induced autophagy in melanoma.''; Sci Rep, 2019 PubMed Europe PMC Scholia
  14. Schiaffino MV; ''Signaling pathways in melanosome biogenesis and pathology.''; Int J Biochem Cell Biol, 2010 PubMed Europe PMC Scholia
  15. Pillaiyar T, Manickam M, Jung SH; ''Recent development of signaling pathways inhibitors of melanogenesis.''; Cell Signal, 2017 PubMed Europe PMC Scholia
  16. Vachtenheim J, Borovanský J; ''"Transcription physiology" of pigment formation in melanocytes: central role of MITF.''; Exp Dermatol, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129343view09:20, 27 March 2024MkutmonOntology Term : 'disease pathway' added !
120578view17:48, 17 December 2021EweitzFix WP-PathVisio graphics mismatch for CREB1 interaction
120577view17:41, 17 December 2021EweitzTighten layout
120576view13:05, 17 December 2021EweitzUse gene symbol
120575view13:00, 17 December 2021EweitzTighten layout
117844view15:15, 22 May 2021EweitzModified title
113647view18:24, 9 November 2020EgonwReplaced an old HMDB identifier
111385view12:20, 5 August 2020Marvin M2Ontology Term : 'retinal pigment epithelial cell' added !
111384view12:20, 5 August 2020Marvin M2Ontology Term : 'melanocyte' added !
111383view12:19, 5 August 2020Marvin M2Ontology Term : 'ocular albinism' added !
111027view05:05, 1 July 2020EgonwReplaced secondary ChEBI identifiers with primairy identifiers.
111001view14:35, 26 June 2020Victor MarxAddition of a new mtabolite (Dopamine) / New title
111000view12:53, 26 June 2020Victor MarxThe MC1R protein databased was change from Swissprot to TrEMBL
110998view07:15, 26 June 2020FehrhartGPR143 change
110945view15:14, 23 June 2020Victor MarxNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADCY2GeneProductENSG00000078295 (Ensembl)
ADCY4GeneProductENSG00000129467 (Ensembl)
ADCY9GeneProductENSG00000162104 (Ensembl)
ARRB1GeneProductENSG00000137486 (Ensembl)
ARRB2GeneProductENSG00000141480 (Ensembl)
ASIPGeneProductENSG00000101440 (Ensembl)
ATPMetaboliteCHEBI:30616 (ChEBI)
CREB1GeneProductENSG00000118260 (Ensembl) phosphorylated by PRKACA/B/G
Ca2+MetaboliteCHEBI:29108 (ChEBI)
DAGMetaboliteCHEBI:17815 (ChEBI)
DCTGeneProductENSG00000080166 (Ensembl)
DCTProteinP40126 (Uniprot-TrEMBL)
DHICAMetaboliteCHEBI:2003 (ChEBI)
DHIMetaboliteCHEBI:27404 (ChEBI)
DQMetaboliteCHEBI:16852 (ChEBI)
Dopachrome MetaboliteHMDB0012931 (HMDB)
DopamineMetaboliteCHEBI:18243 (ChEBI)
GNA15GeneProductENSG00000060558 (Ensembl)
GNAQGeneProductENSG00000156052 (Ensembl)
GNASGeneProductENSG00000087460 (Ensembl)
GPR143GeneProductENSG00000101850 (Ensembl)
GPR143ProteinP51810 (Uniprot-TrEMBL)
IP3MetaboliteCHEBI:18228 (ChEBI)
IQMetaboliteCHEBI:27406 (ChEBI)
ITPR1GeneProductENSG00000150995 (Ensembl) https://www.wikipathways.org/index.php/Pathway:WP35
L-DOPAMetaboliteCHEBI:15765 (ChEBI)
L-tyrosineMetaboliteCHEBI:17895 (ChEBI)
MART-1ProteinQ16655 (Uniprot-TrEMBL)
MC1RProteinQ01726 (Uniprot-TrEMBL)
MITFGeneProductENSG00000187098 (Ensembl)
MITFProteinO75030 (Uniprot-TrEMBL)
MLANAGeneProductENSG00000120215 (Ensembl)
PLCB1GeneProductENSG00000182621 (Ensembl)
PLCB2GeneProductENSG00000137841 (Ensembl)
PLCB3GeneProductENSG00000149782 (Ensembl)
PLCB4GeneProductPLCB4 (HGNC)
PMELGeneProductENSG00000185664 (Ensembl)
PMELProteinP40967 (Uniprot-TrEMBL)
POMCGeneProductENSG00000115138 (Ensembl)
PPiMetaboliteCHEBI:29888 (ChEBI)
PRKACAGeneProductENSG00000072062 (Ensembl)
PRKACBGeneProductENSG00000142875 (Ensembl)
PRKACGGeneProductENSG00000165059 (Ensembl)
PRKCBGeneProductENSG00000166501 (Ensembl)
SERPINF1GeneProductENSG00000132386 (Ensembl)
TYRGeneProductENSG00000077498 (Ensembl)
TYRP1GeneProductENSG00000107165 (Ensembl)
TYRP1ProteinP17643 (Uniprot-TrEMBL)
VEGFAGeneProductENSG00000112715 (Ensembl)
cAMPMetaboliteCHEBI:17489 (ChEBI)

Annotated Interactions

No annotated interactions

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