STING pathway in Kawasaki-like disease and COVID-19 (Homo sapiens)

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1IntravenousimmunoglobulinsCytosolic DNA(viral DNA and damaged mtDNA)Calcium releaseCytokinesIKBKEVitamin D3FCGR2ANLRP3IFNB1IL1BAngiotensin IIF3PyroptosisAspirinGSDMDITPR1CHUKcGAMPTBK1NLRX1STING1IRF3PIRF3PCGASIKBKBPIKBKGNucleusRELANFKBIAPRELNFKB1NFKBIEPRELARELNFKB1NFKBIANFKBIERELANFKBIARELNFKB1NFKBIE


Description

Triggering of the STING pathway by foreign DNA or damaged mitochondrial DNA can activate multiple downstream responses.

The STING pathway is relevant to Kawasaki-like disease in COVID-19.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Berthelot JM, Drouet L, Lioté F; ''Kawasaki-like diseases and thrombotic coagulopathy in COVID-19: delayed over-activation of the STING pathway?''; Emerg Microbes Infect, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129327view14:05, 26 March 2024MkutmonOntology Term : 'disease pathway' added !
123345view09:50, 17 July 2022EgonwAdded two more identifiers
120610view02:18, 18 December 2021EweitzRefine graphics
120609view00:17, 18 December 2021EweitzTighten graphics, refine case
118842view09:21, 2 June 2021EweitzOntology Term : 'COVID-19' added !
118841view09:21, 2 June 2021EweitzOntology Term : 'DOID:934' removed !
115144view18:43, 28 January 2021Khanspersupdated node to label
114103view18:35, 22 December 2020EgonwA class of gene products
114102view18:29, 22 December 2020EgonwConverted Labels to DataNodes
114038view17:53, 17 December 2020EgonwReplaced a ChEBI ID of a dizwitterion with the uncharged alternative with a Wikidata mapping.
113917view03:07, 9 December 2020KhanspersOntology Term : 'viral infectious disease' added !
113916view03:06, 9 December 2020KhanspersOntology Term : 'pattern recognition receptor mediated signaling pathway' added !
113915view22:23, 8 December 2020KhanspersOntology Term : 'Kawasaki disease' added !
113914view22:07, 8 December 2020KhanspersModified description
113913view22:02, 8 December 2020Khanspersadded F3 gene, removed calcium
113825view08:26, 30 November 2020FehrhartModified description
113665view22:48, 10 November 2020KhanspersWork on progress
113664view21:46, 10 November 2020Khansperswork in progress
111341view22:21, 28 July 2020Khansperswork in progress
111340view21:55, 28 July 2020KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Angiotensin IIMetaboliteCHEBI:2719 (ChEBI)
AspirinMetaboliteCHEBI:15365 (ChEBI)
CGASGeneProductENSG00000164430 (Ensembl)
CHUKGeneProductENSG00000213341 (Ensembl)
Calcium releasePathway
CytokinesGeneProductQ212354 (Wikidata)
Cytosolic DNA (viral DNA and damaged mtDNA)GeneProductQ7430 (Wikidata)
F3GeneProductENSG00000117525 (Ensembl)
FCGR2AGeneProductENSG00000143226 (Ensembl)
GSDMDGeneProductENSG00000104518 (Ensembl)
IFNB1GeneProductENSG00000171855 (Ensembl)
IKBKBGeneProductENSG00000104365 (Ensembl)
IKBKEGeneProductENSG00000263528 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl) NEMO
IL1BGeneProductENSG00000125538 (Ensembl)
IRF3GeneProductENSG00000126456 (Ensembl)
ITPR1GeneProductENSG00000150995 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKBIAGeneProductENSG00000100906 (Ensembl)
NFKBIEGeneProductENSG00000146232 (Ensembl)
NLRP3GeneProductENSG00000162711 (Ensembl)
NLRX1GeneProductENSG00000160703 (Ensembl)
PyroptosisPathway
RELAGeneProductENSG00000173039 (Ensembl) RelA
RELGeneProductENSG00000162924 (Ensembl) c-Rel
STING1GeneProductENSG00000184584 (Ensembl)
TBK1GeneProductENSG00000183735 (Ensembl)
Vitamin D3MetaboliteCHEBI:28940 (ChEBI)
cGAMPMetaboliteCHEBI:71580 (ChEBI)

Annotated Interactions

No annotated interactions

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