Hypoxia-dependent proliferation of myoblasts (Mus musculus)
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Description
Molecular mechanisms involved in myogenic proliferation during hypoxia. Black arrow: activation of the signaling pathway/ protein/ molecule. Blunt red arrow: inhibition of the signaling pathway/protein/ molecule.
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Ontology Terms
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- Majmundar AJ, Skuli N, Mesquita RC, Kim MN, Yodh AG, Nguyen-McCarty M, Simon MC; ''O(2) regulates skeletal muscle progenitor differentiation through phosphatidylinositol 3-kinase/AKT signaling.''; Mol Cell Biol, 2012 PubMed Europe PMC Scholia
- Fonville M, Friesema IH, Hengeveld PD, Docters van Leeuwen A, Jahfari S, Harms MG, van Vliet AJ, Hofhuis A, van Pelt W, Sprong H, van den Wijngaard CC; ''Human exposure to tickborne relapsing fever spirochete Borrelia miyamotoi, the Netherlands.''; Emerg Infect Dis, 2014 PubMed Europe PMC Scholia
- Hauerslev S, Vissing J, Krag TO; ''Muscle atrophy reversed by growth factor activation of satellite cells in a mouse muscle atrophy model.''; PLoS One, 2014 PubMed Europe PMC Scholia
- Chargé SB, Rudnicki MA; ''Cellular and molecular regulation of muscle regeneration.''; Physiol Rev, 2004 PubMed Europe PMC Scholia
- Stitt TN, Drujan D, Clarke BA, Panaro F, Timofeyva Y, Kline WO, Gonzalez M, Yancopoulos GD, Glass DJ; ''The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors.''; Mol Cell, 2004 PubMed Europe PMC Scholia
- KRUPER DC, PATTON RA, KOSKOFF YD; ''Delayed object-quality discriminations in hemicerebrectomized monkeys.''; J Comp Physiol Psychol, 1961 PubMed Europe PMC Scholia
- Zhang GW, Gu TX, Sun XJ, Wang C, Qi X, Wang XB, Li-Ling J; ''Edaravone promotes activation of resident cardiac stem cells by transplanted mesenchymal stem cells in a rat myocardial infarction model.''; J Thorac Cardiovasc Surg, 2016 PubMed Europe PMC Scholia
- Lee SJ, McPherron AC; ''Regulation of myostatin activity and muscle growth.''; Proc Natl Acad Sci U S A, 2001 PubMed Europe PMC Scholia
- Garcia LA, King KK, Ferrini MG, Norris KC, Artaza JN; ''1,25(OH)2vitamin D3 stimulates myogenic differentiation by inhibiting cell proliferation and modulating the expression of promyogenic growth factors and myostatin in C2C12 skeletal muscle cells.''; Endocrinology, 2011 PubMed Europe PMC Scholia
- Wang C, Liu W, Liu Z, Chen L, Liu X, Kuang S; ''Hypoxia Inhibits Myogenic Differentiation through p53 Protein-dependent Induction of Bhlhe40 Protein.''; J Biol Chem, 2015 PubMed Europe PMC Scholia
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| AKT | GeneProduct | 11651 (Entrez Gene)  | |
| AMPK | GeneProduct | ||
| Calcitriol | Protein | P70160 (Uniprot-TrEMBL) | |
| DDIT44 | GeneProduct | 74747 (Entrez Gene) | |
| Elf4E | GeneProduct | ||
| FGF | GeneProduct | 14164 (Entrez Gene) | |
| Fbxo32 | GeneProduct | 67731 (Entrez Gene) | |
| HGF | GeneProduct | 15234 (Entrez Gene) | |
| IGF1 | GeneProduct | 16000 (Entrez Gene) | |
| MSTN | GeneProduct | 17700 (Entrez Gene) | |
| MTOR1 | GeneProduct | 56717 (Entrez Gene) | |
| MYF5 | GeneProduct | 17877 (Entrez Gene) | |
| MYOD1 | GeneProduct | 17927 (Entrez Gene) | |
| MYOG | GeneProduct | 17928 (Entrez Gene) | |
| PI3K | GeneProduct | ||
| PI3KR1 | GeneProduct | ||
| RHEB | GeneProduct | 19744 (Entrez Gene) | |
| Smad2 | GeneProduct | 17126 (Entrez Gene) | |
| Smad3 | GeneProduct | 17127 (Entrez Gene) | |
| TSC1 | GeneProduct | 64930 (Entrez Gene) | |
| TSC2 | GeneProduct | 22084 (Entrez Gene) | |
| Trim63 | GeneProduct | 433766 (Entrez Gene) | |
| VEGF | GeneProduct | 22339 (Entrez Gene) | |
| proliferation and late differentiation |
Annotated Interactions
No annotated interactions
