Genes associated with the development of rheumatoid arthritis (Homo sapiens)

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Bibliography

1. Carlton VE, Hu X, Chokkalingam AP, Schrodi SJ, Brandon R, Alexander HC, Chang M, Catanese JJ, Leong DU, Ardlie KG, Kastner DL, Seldin MF, Criswell LA, Gregersen PK, Beasley E, Thomson G, Amos CI, Begovich AB; ''PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis.''; Am J Hum Genet, 2005 PubMed Europe PMC Scholia
2. Begovich AB, Carlton VE, Honigberg LA, Schrodi SJ, Chokkalingam AP, Alexander HC, Ardlie KG, Huang Q, Smith AM, Spoerke JM, Conn MT, Chang M, Chang SY, Saiki RK, Catanese JJ, Leong DU, Garcia VE, McAllister LB, Jeffery DA, Lee AT, Batliwalla F, Remmers E, Criswell LA, Seldin MF, Kastner DL, Amos CI, Sninsky JJ, Gregersen PK; ''A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.''; Am J Hum Genet, 2004 PubMed Europe PMC Scholia
3. Barton A, Bowes J, Eyre S, Symmons D, Worthington J, Silman A; ''Investigation of polymorphisms in the PADI4 gene in determining severity of inflammatory polyarthritis.''; Ann Rheum Dis, 2005 PubMed Europe PMC Scholia
4. Takata Y, Inoue H, Sato A, Tsugawa K, Miyatake K, Hamada D, Shinomiya F, Nakano S, Yasui N, Tanahashi T, Itakura M; ''Replication of reported genetic associations of PADI4, FCRL3, SLC22A4 and RUNX1 genes with rheumatoid arthritis: results of an independent Japanese population and evidence from meta-analysis of East Asian studies.''; J Hum Genet, 2008 PubMed Europe PMC Scholia
5. Klareskog L, Padyukov L, Rönnelid J, Alfredsson L; ''Genes, environment and immunity in the development of rheumatoid arthritis.''; Curr Opin Immunol, 2006 PubMed Europe PMC Scholia
6. Suzuki A, Yamada R, Chang X, Tokuhiro S, Sawada T, Suzuki M, Nagasaki M, Nakayama-Hamada M, Kawaida R, Ono M, Ohtsuki M, Furukawa H, Yoshino S, Yukioka M, Tohma S, Matsubara T, Wakitani S, Teshima R, Nishioka Y, Sekine A, Iida A, Takahashi A, Tsunoda T, Nakamura Y, Yamamoto K; ''Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis.''; Nat Genet, 2003 PubMed Europe PMC Scholia
7. Gregersen PK; ''Pathways to gene identification in rheumatoid arthritis: PTPN22 and beyond.''; Immunol Rev, 2005 PubMed Europe PMC Scholia
8. Viken MK, Olsson M, Flåm ST, Førre O, Kvien TK, Thorsby E, Lie BA; ''The PTPN22 promoter polymorphism -1123G>C association cannot be distinguished from the 1858C>T association in a Norwegian rheumatoidarthritis material.''; Tissue Antigens, 2007 PubMed Europe PMC Scholia
9. Swanberg M, Lidman O, Padyukov L, Eriksson P, Akesson E, Jagodic M, Lobell A, Khademi M, Börjesson O, Lindgren CM, Lundman P, Brookes AJ, Kere J, Luthman H, Alfredsson L, Hillert J, Klareskog L, Hamsten A, Piehl F, Olsson T; ''MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction.''; Nat Genet, 2005 PubMed Europe PMC Scholia
10. Silman AJ, MacGregor AJ, Thomson W, Holligan S, Carthy D, Farhan A, Ollier WE; ''Twin concordance rates for rheumatoid arthritis: results from a nationwide study.''; Br J Rheumatol, 1993 PubMed Europe PMC Scholia
11. van Oene M, Wintle RF, Liu X, Yazdanpanah M, Gu X, Newman B, Kwan A, Johnson B, Owen J, Greer W, Mosher D, Maksymowych W, Keystone E, Rubin LA, Amos CI, Siminovitch KA; ''Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations.''; Arthritis Rheum, 2005 PubMed Europe PMC Scholia
12. Gregersen PK, Silver J, Winchester RJ; ''The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis.''; Arthritis Rheum, 1987 PubMed Europe PMC Scholia
13. Caponi L, Petit-Teixeira E, Sebbag M, Bongiorni F, Moscato S, Pratesi F, Pierlot C, Osorio J, Chapuy-Regaud S, Guerrin M, Cornelis F, Serre G, Migliorini P; ''A family based study shows no association between rheumatoid arthritis and the PADI4 gene in a white French population.''; Ann Rheum Dis, 2005 PubMed Europe PMC Scholia
14. Firestein GS; ''The disease formerly known as rheumatoid arthritis.''; Arthritis Res Ther, 2014 PubMed Europe PMC Scholia

History

External references

DataNodes

Name	Type	Database reference	Comment
BLK	GeneProduct	ENSG00000136573 (Ensembl)
CCR6	GeneProduct	ENSG00000112486 (Ensembl)
CD244	GeneProduct	ENSG00000122223 (Ensembl)
CD40	GeneProduct	ENSG00000101017 (Ensembl)
CIITA	GeneProduct	ENSG00000179583 (Ensembl)
CTLA4	GeneProduct	ENSG00000163599 (Ensembl)
FCRL3	GeneProduct	ENSG00000160856 (Ensembl)
HLA-DRB1	GeneProduct	ENSG00000196126 (Ensembl)
IL2RA	GeneProduct	ENSG00000134460 (Ensembl)	rs1953126 associated with RA
IL6ST	GeneProduct	ENSG00000134352 (Ensembl)
IRF5	GeneProduct	ENSG00000128604 (Ensembl)
ITGAV	GeneProduct	ENSG00000138448 (Ensembl)	rs1953126 associated with RA
PADI4	GeneProduct	ENSG00000159339 (Ensembl)
PHF19	GeneProduct	ENSG00000119403 (Ensembl)	rs1953126 associated with RA
PTPN22	GeneProduct	ENSG00000134242 (Ensembl)
SLC22A4	GeneProduct	ENSG00000197208 (Ensembl)
STAT4	GeneProduct	ENSG00000138378 (Ensembl)
TRAF1	GeneProduct	ENSG00000056558 (Ensembl)
chronic inflammation	Pathway
citrullination	Pathway

Annotated Interactions

No annotated interactions