Angiotensin II receptor type 1 pathway (Homo sapiens)

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2, 4-62, 4-71, 6FibrosisMyofibroblast transitionPro-oxidantLung vascular smooth muscle cellIntrinsic coagulation pathwayContractionprostaglandins, VEGF, basic-FGF,PDGF-sJNKLung fibroblastAlveolar epithelial cellTGFBR1Ang 1-7NOX4MKKMAPK1MAS1TGFBR2RACK1ACE2RasRAFAngiotensinogenSMAD4PDGFDIL11RAACTA2SP1AGTR1SMAD3JUNDInterleukin-11 signaling pathwayIL11Angiotensin IICTGFF12HIF1A3ApoptosisTGFB1Cell cycleIL6STPTPN11COL1A1Complement and coagulation cascadesAGTR1AGTR1COL1A2TGFB1IL11COL1A1COL1A2Angiotensin IIAngiotensin IITGFB1RAS / NRASSMAD3PAngiotensinogenMAPK1PNOX4COL1A1COL1A1RasRAFMKKMAPK1MAPK1PTGFB1TGFBR1TGFBR2SMAD3SMAD4SMAD3PROS, NF-kappa-B and inflammatory mediators leading to cytokine stormGeneLegendComplexActivatesInhibitsMetabolitePathwayDirect interactionIndirect interactionCatalysisNecessary stimulationTransportationPhosphorylatedPProtein kinase CfamilyROS, NF-kappa-B and inflammatory mediators leading to cytokine stormFibrosis


Description

Angiotensin II binds its type-1 receptor (AGTR1) triggering distinct pathways in various cell types. Here the pathways in lung fibroblasts, lung vascular smooth muscle cells, and alveolar epithelium are detailed.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. López-Bergami P, Habelhah H, Bhoumik A, Zhang W, Wang LH, Ronai Z; ''RACK1 mediates activation of JNK by protein kinase C [corrected].''; Mol Cell, 2005 PubMed Europe PMC Scholia
  2. Ford CM, Li S, Pickering JG; ''Angiotensin II stimulates collagen synthesis in human vascular smooth muscle cells. Involvement of the AT(1) receptor, transforming growth factor-beta, and tyrosine phosphorylation.''; Arterioscler Thromb Vasc Biol, 1999 PubMed Europe PMC Scholia
  3. van der Meijden PE, Munnix IC, Auger JM, Govers-Riemslag JW, Cosemans JM, Kuijpers MJ, Spronk HM, Watson SP, Renné T, Heemskerk JW; ''Dual role of collagen in factor XII-dependent thrombus formation.''; Blood, 2009 PubMed Europe PMC Scholia
  4. Zhang K, Phan SH; ''Cytokines and pulmonary fibrosis.''; Biol Signals, 1996 PubMed Europe PMC Scholia
  5. Chappell MC; ''Emerging evidence for a functional angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS receptor axis: more than regulation of blood pressure?''; Hypertension, 2007 PubMed Europe PMC Scholia
  6. Uhal BD, Li X, Piasecki CC, Molina-Molina M; ''Angiotensin signalling in pulmonary fibrosis.''; Int J Biochem Cell Biol, 2012 PubMed Europe PMC Scholia
  7. Ng B, Cook SA, Schafer S; ''Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway.''; Exp Mol Med, 2020 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
128622view01:17, 17 February 2024EweitzUpgrade disease nodes, refinement alignments, economize layout
128621view01:06, 17 February 2024EweitzEconomize layout
128620view00:49, 17 February 2024EweitzRefine legend, economize layout
128619view00:33, 17 February 2024EweitzEconomize layout
128618view00:22, 17 February 2024EweitzEconomize layout
128614view00:02, 17 February 2024EweitzEconomize layout
128613view23:38, 16 February 2024EweitzStandardize case
128585view23:26, 14 February 2024EweitzOntology Term : 'epithelial cell' added !
128584view23:25, 14 February 2024EweitzOntology Term : 'smooth muscle cell' added !
128583view23:24, 14 February 2024EweitzOntology Term : 'vascular associated smooth muscle cell' added !
128582view23:24, 14 February 2024EweitzOntology Term : 'fibroblast of lung' added !
125920view05:57, 20 March 2023EgonwNot a mim-conversion
125625view20:09, 5 March 2023AlexanderPicoModified description
125259view11:43, 31 January 2023EgonwRemoved two more duplicate references
125258view11:41, 31 January 2023EgonwRemoved duplicate references and fixed character encoding issues
119016view18:50, 9 June 2021EgonwNot a mim-conversion
118782view18:31, 1 June 2021RaatsSlegend changes
118202view08:00, 26 May 2021RaatsSID fix and legend addition
117648view11:42, 22 May 2021EweitzModified title
116387view12:55, 6 May 2021RaatsSfixed unclickable pathway
116386view12:54, 6 May 2021RaatsSfixed unclickable pathway link
116385view11:23, 6 May 2021RaatsSReplaced nodes with a new pathway.
116324view12:36, 30 April 2021Marvin M2double datanode pathway removed
116323view12:24, 30 April 2021Marvin M2minor edits, WP IDs fixed
116272view11:22, 23 April 2021RaatsSModified description
116271view11:17, 23 April 2021RaatsSExpanded and elaborated the pathway
115405view21:28, 17 February 2021KhanspersOntology Term : 'angiotensin II signaling pathway' added !
115404view21:28, 17 February 2021KhanspersOntology Term : 'signaling pathway' added !
114331view10:31, 8 January 2021Marvin M2small graphical update
114330view11:21, 7 January 2021Marvin M2Added pathway link for coagulation
114329view11:18, 7 January 2021Marvin M2Updated layout, added link to coagulation
114328view10:58, 7 January 2021Marvin M2rounded rectangles for pathways
114327view10:57, 7 January 2021Marvin M2New pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACE2ProteinQ9BYF1 (Uniprot-TrEMBL)
ACTA2GeneProductENSG00000107796 (Ensembl)
AGTR1GeneProductENSG00000144891 (Ensembl)
Ang 1-7MetaboliteCHEBI:55438 (ChEBI)
Angiotensin IIMetaboliteCHEBI:58506 (ChEBI)
AngiotensinogenProteinP01019 (Uniprot-TrEMBL)
ApoptosisPathwayWP254 (WikiPathways)
COL1A1GeneProductENSG00000108821 (Ensembl)
COL1A2GeneProductENSG00000164692 (Ensembl)
CTGFGeneProductENSG00000118523 (Ensembl)
Cell cyclePathwayWP179 (WikiPathways)
Complement and coagulation cascadesPathwayWP558 (WikiPathways)
F12GeneProductENSG00000131187 (Ensembl)
FibrosisQ605709 (Wikidata)
HIF1AGeneProductENSG00000100644 (Ensembl)
IL11GeneProductENSG00000095752 (Ensembl)
IL11RAGeneProductENSG00000137070 (Ensembl)
IL6STGeneProductENSG00000134352 (Ensembl)
Interleukin-11 signaling pathwayPathwayWP2332 (WikiPathways)
JUNDGeneProductENSG00000130522 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAS1GeneProductENSG00000130368 (Ensembl)
MKKGeneProductENSG00000108984 (Ensembl)
NOX4GeneProduct50507 (Entrez Gene)
PDGFDGeneProductENSG00000170962 (Ensembl)
PTPN11GeneProductENSG00000179295 (Ensembl)
RACK1GeneProductENSG00000204628 (Ensembl)
RAFGeneProductENSG00000132155 (Ensembl)
RAS / NRASPathwayWP4818 (WikiPathways)
ROS, NF-kappa-B and

inflammatory mediators

leading to cytokine storm		PathwayWP5095 (WikiPathways)
RasGeneProductENSG00000126458 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SP1GeneProductENSG00000185591 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFBR1GeneProductENSG00000106799 (Ensembl)
TGFBR2GeneProductENSG00000163513 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5036"
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