Nephrogenesis (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none 2. Primed nephron progenitorFrom ureteric bud4. Comma-shaped stage1. Induction of pretubular aggregate3. Epithelialized renal vesicleStromal progenitorFOXD1TCF21MEIS1ALDH1A2Nephron progenitor cellOSR1FGF20GREB1LSIX2BMP7Pretubular aggregateFGF8WNT4LHX1WNT9BWNT3AJAG1PAX2RSPO1RSPO3NOTCH2Name: NephrogenesisOrganism: Homo sapiens


Description

This pathway describes the gene signaling pathways active in early nephrogenesis in human development. Mutations in essential genes can lead to development of CAKUT (congenital anomalies of the kidney and urinary tract).

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Quality Tags

Image:Wplogo_31.pngCommunity: Rare Diseases
Image:Curated.pngApproved version

Ontology Terms

Disease : Fanconi's anemia
 

Bibliography

  1. Cheng HT, Kim M, Valerius MT, Surendran K, Schuster-Gossler K, Gossler A, McMahon AP, Kopan R; ''Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron.''; Development, 2007 PubMed Europe PMC Scholia
  2. Vivante A, Mark-Danieli M, Davidovits M, Harari-Steinberg O, Omer D, Gnatek Y, Cleper R, Landau D, Kovalski Y, Weissman I, Eisenstein I, Soudack M, Wolf HR, Issler N, Lotan D, Anikster Y, Dekel B; ''Renal hypodysplasia associates with a WNT4 variant that causes aberrant canonical WNT signaling.''; J Am Soc Nephrol, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134598
RARE
Approved
view01:11, 23 July 2024EweitzModified description
134597view01:10, 23 July 2024EweitzStandardize case
118777view15:58, 1 June 2021FehrhartOntology Term : 'CAKUT' added !
118775view15:56, 1 June 2021Fehrhartadded WNT4 interaction with WNT3A
115258view09:18, 8 February 2021FehrhartModified description
115255view09:02, 8 February 2021FehrhartOntology Term : 'kidney disease' added !
115254view09:02, 8 February 2021FehrhartOntology Term : 'Notch signaling pathway' added !
115253view09:01, 8 February 2021FehrhartOntology Term : 'signaling pathway' added !
115249view08:47, 8 February 2021FehrhartNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ALDH1A2GeneProductENSG00000128918 (Ensembl)
BMP7GeneProductENSG00000101144 (Ensembl)
FGF20GeneProductENSG00000078579 (Ensembl)
FGF8GeneProductENSG00000107831 (Ensembl)
FOXD1GeneProductENSG00000251493 (Ensembl)
GREB1LGeneProductENSG00000141449 (Ensembl)
JAG1GeneProductENSG00000101384 (Ensembl)
LHX1GeneProductENSG00000274577 (Ensembl)
MEIS1GeneProductENSG00000143995 (Ensembl)
NOTCH2GeneProductENSG00000134250 (Ensembl)
OSR1GeneProductENSG00000143867 (Ensembl)
PAX2GeneProductENSG00000075891 (Ensembl)
RSPO1GeneProductENSG00000169218 (Ensembl)
RSPO3GeneProductENSG00000146374 (Ensembl)
SIX2GeneProductENSG00000170577 (Ensembl)
TCF21GeneProductENSG00000118526 (Ensembl)
WNT3AGeneProductENSG00000154342 (Ensembl)
WNT4GeneProductENSG00000162552 (Ensembl)
WNT9B GeneProductENSG00000158955 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5052"
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