FOXP3 in COVID-19 (Homo sapiens)
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Description
FOXP3 in Covid-19
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Ontology Terms
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- S Hori, T Nomura, S Sakaguchi; ''Control of regulatory T cell development by the transcription factor Foxp3 ''; Science, 2003 PubMed Europe PMC Scholia
- A Shimizu, S Kondo, H Sabe, N Ishida, T Honjo; ''Structure and function of the interleukin 2 receptor: affinity conversion model''; Immunological reviews, 1986 PubMed Europe PMC Scholia
- E Bettelli, Y Carrier, W Gao, T Korn, TB Strom, M Oukka, HL Weiner, VK Kuchroo; ''Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells ''; Nature, 2006 PubMed Europe PMC Scholia
- M Ono, RJ Tanaka; ''Controversies concerning thymus-derived regulatory T cells: fundamental issues and a new perspective''; Immunology & Cell biology, 2016 PubMed Europe PMC Scholia
- K Freudenberg, N Lindner, S Dohnke, AI Garbe, S Schallenberg, K Kretschmer; ''Critical Role of TGF-β and IL-2 Receptor Signaling in Foxp3 Induction by an Inhibitor of DNA Methylation ''; Frontiers in Immunology, 2018 PubMed Europe PMC Scholia
- D Bending, M Ono; ''From stability to dynamics: understanding molecular mechanisms of regulatory T cells through Foxp3 transcriptional dynamics ''; Clinical and experimental immunology, 2019 PubMed Europe PMC Scholia
- C Orabona, U Grohmann, ML Belladonna, F Fallarino, G Vacca, R Bianchi, S Bozza, C Volpi, BL Salomon, MC Fioretti, L Romani, P Pucetti; ''CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86''; Nature immunology, 2004 PubMed Europe PMC Scholia
- B Kalfaoglu, J Almeida-Santos, CA Tye, Y Satou, M Ono; ''T-Cell Hyperactivation and Paralysis in Severe COVID-19 Infection Revealed by Single-Cell Analysis ''; Frontiers in Immunology, 2020 PubMed Europe PMC Scholia
- C Huang, Y Wang, X Li, L Ren, J Zhao, Y Hu, L Zhang, G Fan, J Xu, X Gu, Z Cheng, T Yu, J Xia, Y Wei, W Wu, X Xie, W Yin, H Li, M Liu, Y Xiao, H Gao, L Guo, J Xie, G Wang, R Jiang, Z Gao, Q Jin, J Wang, B Cao; ''Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China''; Lancet, 2020 PubMed Europe PMC Scholia
- H Shi, W Wang, J Yin, Y Ouyang, L Pang, Y Feng, L Qiao, X Guo, H Shi, R Jin, D Chen; ''The inhibition of IL-2/IL-2R gives rise to CD8 + T cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumonia ''; Cell death and disease, 2020 PubMed Europe PMC Scholia
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| CD28 | Protein | P10747 (Uniprot-TrEMBL)  | |
| CD80 | Protein | P33681 (Uniprot-TrEMBL) | |
| CD86 | Protein | P42081 (Uniprot-TrEMBL) | |
| FOXP3 | Protein | B7ZLG1 (Uniprot-TrEMBL) | |
| FOXP3 | GeneProduct | ENSG00000049768 (Ensembl) | |
| IL2 | GeneProduct | IL2 (HGNC) | |
| IL2RA | GeneProduct | IL2RA (HGNC) | |
| IL2RB | GeneProduct | IL2RB (HGNC) | |
| IL2RG | GeneProduct | IL2RG (HGNC) | |
| IL6 | GeneProduct | IL6 (HGNC) | |
| IL6R | GeneProduct | IL6R (HGNC) | |
| IL6ST | GeneProduct | IL6ST (HGNC) | |
| IL7R | GeneProduct | IL7R (HGNC) | |
| MHC-II alpha | Complex | PF00993 (Pfam) | |
| MHC-II beta | Protein | PF00969 (Pfam) | |
| STAT3 | GeneProduct | STAT3 (HGNC) | |
| STAT5A | GeneProduct | ENSG00000126561 (Ensembl) | |
| STAT5B | GeneProduct | ENSG00000173757 (Ensembl) | |
| TCR | Protein |
Annotated Interactions
No annotated interactions
