FOXA2 pathway (Homo sapiens)
From WikiPathways
Description
Role of Foxa2
Quality Tags
Ontology Terms
Bibliography
- Gao N, Le Lay J, Qin W, Doliba N, Schug J, Fox AJ, Smirnova O, Matschinsky FM, Kaestner KH; ''Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell.''; Mol Endocrinol, 2010 PubMed Europe PMC Scholia
- Horton JD; ''Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis.''; Biochem Soc Trans, 2002 PubMed Europe PMC Scholia
- Wolfrum C, Besser D, Luca E, Stoffel M; ''Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization.''; Proc Natl Acad Sci U S A, 2003 PubMed Europe PMC Scholia
- Bochkis IM, Rubins NE, White P, Furth EE, Friedman JR, Kaestner KH; ''Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress.''; Nat Med, 2008 PubMed Europe PMC Scholia
- Wolfrum C, Stoffel M; ''Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion.''; Cell Metab, 2006 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
ABCC2 | GeneProduct | ENSG00000023839 (Ensembl) | |
ABCC3 | GeneProduct | ENSG00000108846 (Ensembl) | |
ABCC4 | GeneProduct | ENSG00000125257 (Ensembl) | |
Acetyl-CoA carboxylase 1 | Protein | Q13085 (Uniprot-TrEMBL) | |
Apolipoprotein B-100 | Protein | P04114 (Uniprot-TrEMBL) | |
ChREBP | Protein | Q9NP71 (Uniprot-TrEMBL) | |
FASN | GeneProduct | ENSG00000169710 (Ensembl) | |
FOXA1 | GeneProduct | ENSG00000129514 (Ensembl) | |
FOXA2 | GeneProduct | ENSG00000125798 (Ensembl) | |
FOXA2 | GeneProduct | ENSG00000125798 (Ensembl) | |
FOXO1 | GeneProduct | ENSG00000150907 (Ensembl) | |
GSTA1 | GeneProduct | ENSG00000243955 (Ensembl) | |
GSTA2 | GeneProduct | ENSG00000244067 (Ensembl) | |
GSTM2 | GeneProduct | ENSG00000213366 (Ensembl) | |
IRS1 | GeneProduct | ENSG00000169047 (Ensembl) | |
IRS2 | GeneProduct | ENSG00000185950 (Ensembl) | |
Insulin | Protein | A6XGL2 (Uniprot-TrEMBL) | |
MTTP | GeneProduct | ENSG00000138823 (Ensembl) | |
PPARGC1B | GeneProduct | ENSG00000155846 (Ensembl) | |
SLC27A5 | GeneProduct | ENSG00000083807 (Ensembl) | |
SLCO1B1 | GeneProduct | ENSG00000134538 (Ensembl) | |
SREBP-1c | Protein | P36956 (Uniprot-TrEMBL) | |
TAGs | Metabolite | 17855 (ChEBI) |
Annotated Interactions
No annotated interactions