Modulators of TCR signaling and T cell activation (Homo sapiens)

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Description

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Ontology Terms

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Bibliography

1. Shifrut E, Carnevale J, Tobin V, Roth TL, Woo JM, Bui CT, Li PJ, Diolaiti ME, Ashworth A, Marson A; ''Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function.''; Cell, 2018 PubMed Europe PMC Scholia
2. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

External references

DataNodes

Name	Type	Database reference	Comment
AGO1	GeneProduct	ENSG00000092847 (Ensembl)
AKT1	Protein	ENSG00000142208 (Ensembl)
ARIH2	GeneProduct	ENSG00000177479 (Ensembl)
BCL10	Protein	ENSG00000142867 (Ensembl)
CARD11	Protein	ENSG00000198286 (Ensembl)
CBLB	Protein	868 (Entrez Gene)
CD247	Protein	ENSG00000198821 (Ensembl)
CD28	Protein	ENSG00000178562 (Ensembl)
CD3D	Protein	ENSG00000167286 (Ensembl)
CD3E	Protein	916 (Entrez Gene)
CD3E	Protein	ENSG00000198851 (Ensembl)
CD3G	Protein	ENSG00000160654 (Ensembl)
CD5	GeneProduct	ENSG00000110448 (Ensembl)
CD8A	Protein	ENSG00000153563 (Ensembl)
CDKN1B	GeneProduct	ENSG00000111276 (Ensembl)
CHUK	Protein	ENSG00000213341 (Ensembl)
CUL5	GeneProduct	ENSG00000166266 (Ensembl)
DAG	Metabolite	18035 (ChEBI)
DGKA	GeneProduct	ENSG00000065357 (Ensembl)
DGKZ	GeneProduct	ENSG00000149091 (Ensembl)
FIBP	GeneProduct	ENSG00000172500 (Ensembl)
GNA13	GeneProduct	ENSG00000120063 (Ensembl)
GRAP2	Protein	ENSG00000100351 (Ensembl)
GRB2	Protein	ENSG00000177885 (Ensembl)
IKBKB	Protein	ENSG00000104365 (Ensembl)
IKBKG	Protein	ENSG00000269335 (Ensembl)
ITK	Protein	ENSG00000113263 (Ensembl)
LAT	Protein	ENSG00000213658 (Ensembl)
LCK	Protein	ENSG00000182866 (Ensembl)
LCP2	Protein	ENSG00000043462 (Ensembl)
MALT1	Protein	ENSG00000172175 (Ensembl)
MAP3K14	Protein	ENSG00000006062 (Ensembl)
MAP3K8	Protein	ENSG00000107968 (Ensembl)
MAP4K1	Protein	ENSG00000104814 (Ensembl)
MEF2D	GeneProduct	ENSG00000116604 (Ensembl)
NDUFB10	GeneProduct	ENSG00000140990 (Ensembl)
NFKB1	Protein	ENSG00000109320 (Ensembl)
NFKBIA	Protein	ENSG00000100906 (Ensembl)
PCBP2	GeneProduct	ENSG00000197111 (Ensembl)
PDPK1	Protein	ENSG00000140992 (Ensembl)
PIK3R1	Protein	ENSG00000145675 (Ensembl)
PIK3R2	Protein	ENSG00000105647 (Ensembl)
PLCG1	Protein	ENSG00000124181 (Ensembl)
PRKCQ	Protein	ENSG00000065675 (Ensembl)
PTPN6	GeneProduct	ENSG00000111679 (Ensembl)
RASA2	GeneProduct	ENSG00000155903 (Ensembl)
RELA	Protein	ENSG00000173039 (Ensembl)
REL	Protein	ENSG00000162924 (Ensembl)
RHOH	GeneProduct	ENSG00000168421 (Ensembl)
RNF7	GeneProduct	ENSG00000114125 (Ensembl)
RPRD1B	GeneProduct	ENSG00000101413 (Ensembl)
SH2B3	Protein	ENSG00000111252 (Ensembl)
SH2D1A	GeneProduct	ENSG00000183918 (Ensembl)
SMARCB1	GeneProduct	ENSG00000099956 (Ensembl)
SOCS1	GeneProduct	ENSG00000185338 (Ensembl)
TCEB2	GeneProduct	ENSG00000103363 (Ensembl)
TMEM222	GeneProduct	ENSG00000186501 (Ensembl)
TNFAIP3	GeneProduct	ENSG00000118503 (Ensembl)
TRA ALPHA	Protein	6955 (Entrez Gene)
TRAF6	Protein	ENSG00000175104 (Ensembl)
TRB BETA	Protein	6957 (Entrez Gene)
UBASH3A	GeneProduct	ENSG00000160185 (Ensembl)
VAV1	Protein	ENSG00000141968 (Ensembl)
ZAP70	Protein	ENSG00000115085 (Ensembl)
ZFP36L1	GeneProduct	ENSG00000185650 (Ensembl)

Annotated Interactions

No annotated interactions