PPAR Beta/Delta pathway (Homo sapiens)

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1-3DNA bindingIL1RNLPLPDK4PPARdelta agonistBCL6UCP1VCAM1PPARDPLIN2MMP9CCL2CPT1ARELANFKB1RELEP300CREBBPRXRANCOA1RXRBRXRGRXRAPPARDRXRBRXRGPTGS2IL1ATNFIL1BDNA bindingDNA bindingUCP2UCP3


Description

The Peroxisome Proliferator-Activated Receptor Delta forms a complex with the transcription factor BCL6, which prevents BCL6 from repressing proinflammatory cytokine genes. When a ligand binds to PPARD, the complex separates. PPARD can form a complex with NFkB or with RXRs to have varying effects.This pathway is based on the entry on the PPARG pathway on Nuclear Receptor Resource (https://nrresource.org/nuclear_receptors/peroxisome-proliferator-activated-receptor-delta-ppard-nr1c2/).

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Ontology Terms

 

Bibliography

  1. Liu Y, Colby JK, Zuo X, Jaoude J, Wei D, Shureiqi I; ''The Role of PPAR-δ in Metabolism, Inflammation, and Cancer: Many Characters of a Critical Transcription Factor.''; Int J Mol Sci, 2018 PubMed Europe PMC Scholia
  2. Wolf G; ''The function of the nuclear receptor peroxisome proliferator-activated receptor delta in energy homeostasis.''; Nutr Rev, 2003 PubMed Europe PMC Scholia
  3. Kadayat TM, Shrestha A, Jeon YH, An H, Kim J, Cho SJ, Chin J; ''Targeting Peroxisome Proliferator-Activated Receptor Delta (PPARδ): A Medicinal Chemistry Perspective.''; J Med Chem, 2020 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
115726view08:39, 9 March 2021Marvin M2Changed ChEBI ID to primary ID
115725view08:36, 9 March 2021Marvin M2Ontology Term : 'signaling pathway' added !
115724view08:35, 9 March 2021Marvin M2Ontology Term : 'peroxisome proliferator-activated receptor signaling pathway' added !
115723view08:34, 9 March 2021Marvin M2New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BCL6GeneProductENSG00000113916 (Ensembl)
CCL2GeneProductENSG00000108691 (Ensembl)
CPT1AGeneProductENSG00000110090 (Ensembl)
CREBBPGeneProductENSG00000005339 (Ensembl)
EP300GeneProductEP300 (HGNC)
IL1AGeneProductENSG00000115008 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL1RNGeneProductENSG00000136689 (Ensembl)
LPLGeneProductENSG00000175445 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
NCOA1GeneProductENSG00000084676 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
PDK4GeneProductENSG00000004799 (Ensembl)
PLIN2GeneProductENSG00000147872 (Ensembl)
PPARDGeneProductENSG00000112033 (Ensembl)
PPARdelta agonistMetaboliteCHEBI:73730 (ChEBI)
PTGS2GeneProductENSG00000073756 (Ensembl)
RELAGeneProductENSG00000173039 (Ensembl)
RELGeneProductENSG00000162924 (Ensembl)
RXRAGeneProductENSG00000186350 (Ensembl)
RXRBGeneProductENSG00000204231 (Ensembl)
RXRGGeneProductENSG00000143171 (Ensembl)
TNFGeneProductTNF (HGNC)
UCP1GeneProductENSG00000109424 (Ensembl)
UCP2GeneProductENSG00000175567 (Ensembl)
UCP3GeneProductENSG00000175564 (Ensembl)
VCAM1GeneProductENSG00000162692 (Ensembl)

Annotated Interactions

No annotated interactions

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