Vasopressin-regulated water reabsorption (Homo sapiens)
From WikiPathways
Description
This pathway describes Vasopressin-regulated water reabsorption from the kidney tubules of the nephrons back into the circulation. Vasopressin, antidiuretic hormone (ADH), is a peptide hormone produced in neurons of the hypothalamus in response to changes in response to extracellular fluid hypertonicity (hyperosmolality), and is secreted into the circulation. When it reaches the kidney, it binds to Vasopressin 2 receptors, triggering an intracellular signaling cascade that ultimately leads to aquaporin 2 (AQP2) vesicles inserted in the apical membrane. This increases the water permeability of the membrane. An osmotic gradient then drives water transport from the collecting duct through AQP2, and water exits the cell on the basolateral side, and back into the circulation.
This description was adapted from Wikipedia and KEGG.
This pathway was modeled from KEGG.Quality Tags
Ontology Terms
Bibliography
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- Boone M, Deen PM; ''Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption.''; Pflugers Arch, 2008 PubMed Europe PMC Scholia
- Takata K, Matsuzaki T, Tajika Y, Ablimit A, Hasegawa T; ''Localization and trafficking of aquaporin 2 in the kidney.''; Histochem Cell Biol, 2008 PubMed Europe PMC Scholia
- Nielsen S, Kwon TH, Christensen BM, Promeneur D, Frøkiaer J, Marples D; ''Physiology and pathophysiology of renal aquaporins.''; J Am Soc Nephrol, 1999 PubMed Europe PMC Scholia
- Marples D, Frøkiaer J, Nielsen S; ''Long-term regulation of aquaporins in the kidney.''; Am J Physiol, 1999 PubMed Europe PMC Scholia
- Ward DT, Hammond TG, Harris HW; ''Modulation of vasopressin-elicited water transport by trafficking of aquaporin2-containing vesicles.''; Annu Rev Physiol, 1999 PubMed Europe PMC Scholia
- Fenton RA, Moeller HB; ''Recent discoveries in vasopressin-regulated aquaporin-2 trafficking.''; Prog Brain Res, 2008 PubMed Europe PMC Scholia
- Nielsen S, Frøkiaer J, Marples D, Kwon TH, Agre P, Knepper MA; ''Aquaporins in the kidney: from molecules to medicine.''; Physiol Rev, 2002 PubMed Europe PMC Scholia
- Deen PM, van Balkom BW, Kamsteeg EJ; ''Routing of the aquaporin-2 water channel in health and disease.''; Eur J Cell Biol, 2000 PubMed Europe PMC Scholia
- Bonilla-Felix M; ''Development of water transport in the collecting duct.''; Am J Physiol Renal Physiol, 2004 PubMed Europe PMC Scholia
- Uawithya P, Pisitkun T, Ruttenberg BE, Knepper MA; ''Transcriptional profiling of native inner medullary collecting duct cells from rat kidney.''; Physiol Genomics, 2008 PubMed Europe PMC Scholia
- Nguyen MK, Nielsen S, Kurtz I; ''Molecular pathogenesis of nephrogenic diabetes insipidus.''; Clin Exp Nephrol, 2003 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
ADCY3 | GeneProduct | ENSG00000138031 (Ensembl) | |
ADCY6 | GeneProduct | ENSG00000174233 (Ensembl) | |
ADCY9 | GeneProduct | ENSG00000162104 (Ensembl) | |
AQP2 | GeneProduct | ENSG00000167580 (Ensembl) | |
AQP3 | GeneProduct | ENSG00000165272 (Ensembl) | |
AQP4 | GeneProduct | ENSG00000171885 (Ensembl) | |
ARHGDIA | GeneProduct | ENSG00000141522 (Ensembl) | |
ARHGDIB | GeneProduct | ENSG00000111348 (Ensembl) | |
ARHGDIG | GeneProduct | ENSG00000242173 (Ensembl) | |
AVP | GeneProduct | ENSG00000101200 (Ensembl) | |
AVPR2 | GeneProduct | ENSG00000126895 (Ensembl) | |
CREB1 | GeneProduct | ENSG00000118260 (Ensembl) | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12912 |
CREB3 | GeneProduct | ENSG00000107175 (Ensembl) | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12913 |
CREB3L1 | GeneProduct | ENSG00000157613 (Ensembl) | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:26427 |
CREB3L2 | GeneProduct | ENSG00000182158 (Ensembl) | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208647 |
CREB3L3 | GeneProduct | ENSG00000060566 (Ensembl) | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208677 |
CREB3L4 | GeneProduct | ENSG00000143578 (Ensembl) | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:78284 |
CREB5 | GeneProduct | ENSG00000146592 (Ensembl) | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:231991 |
DCTN1 | GeneProduct | ENSG00000204843 (Ensembl) | |
DCTN2 | GeneProduct | ENSG00000175203 (Ensembl) | |
DCTN4 | GeneProduct | ENSG00000132912 (Ensembl) | |
DCTN5 | GeneProduct | ENSG00000166847 (Ensembl) | |
DCTN6 | GeneProduct | ENSG00000104671 (Ensembl) | |
DYNC1H1 | GeneProduct | ENSG00000197102 (Ensembl) | |
DYNC1I1 | GeneProduct | ENSG00000158560 (Ensembl) | |
DYNC1I2 | GeneProduct | ENSG00000077380 (Ensembl) | |
DYNC1LI1 | GeneProduct | ENSG00000144635 (Ensembl) | |
DYNC1LI2 | GeneProduct | ENSG00000135720 (Ensembl) | |
DYNC2H1 | GeneProduct | ENSG00000187240 (Ensembl) | |
DYNC2LI1 | GeneProduct | ENSG00000138036 (Ensembl) | |
DYNLL1 | GeneProduct | ENSG00000088986 (Ensembl) | |
DYNLL2 | GeneProduct | ENSG00000264364 (Ensembl) | |
GNAS | GeneProduct | ENSG00000087460 (Ensembl) | |
NSF | GeneProduct | ENSG00000073969 (Ensembl) | |
PRKACA | GeneProduct | ENSG00000072062 (Ensembl) | |
PRKACB | GeneProduct | ENSG00000142875 (Ensembl) | |
PRKACG | GeneProduct | ENSG00000165059 (Ensembl) | |
RAB11A | GeneProduct | ENSG00000103769 (Ensembl) | |
RAB11B | GeneProduct | ENSG00000185236 (Ensembl) | |
RAB5A | GeneProduct | ENSG00000144566 (Ensembl) | |
RAB5B | GeneProduct | ENSG00000111540 (Ensembl) | |
RAB5C | GeneProduct | ENSG00000108774 (Ensembl) | |
STX4 | GeneProduct | ENSG00000103496 (Ensembl) | |
VAMP2 | GeneProduct | ENSG00000220205 (Ensembl) | |
Water | Metabolite | HMDB02111 (HMDB) | |
cAMP | Metabolite | HMDB00058 (HMDB) |
Annotated Interactions
No annotated interactions