Pleural mesothelioma (Homo sapiens)

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Bibliography

1. Chu GJ, van Zandwijk N, Rasko JEJ; ''The Immune Microenvironment in Mesothelioma: Mechanisms of Resistance to Immunotherapy.''; Front Oncol, 2019 PubMed Europe PMC Scholia
2. Mossman BT, Shukla A, Heintz NH, Verschraegen CF, Thomas A, Hassan R; ''New insights into understanding the mechanisms, pathogenesis, and management of malignant mesotheliomas.''; Am J Pathol, 2013 PubMed Europe PMC Scholia
3. Bitra A, Sistla S, Mariam J, Malvi H, Anand R; ''Rassf Proteins as Modulators of Mst1 Kinase Activity.''; Sci Rep, 2017 PubMed Europe PMC Scholia
4. Hylebos M, Van Camp G, Vandeweyer G, Fransen E, Beyens M, Cornelissen R, Suls A, Pauwels P, van Meerbeeck JP, Op de Beeck K; ''Large-scale copy number analysis reveals variations in genes not previously associated with malignant pleural mesothelioma.''; Oncotarget, 2017 PubMed Europe PMC Scholia
5. Liu XL, Zuo R, Ou WB; ''The hippo pathway provides novel insights into lung cancer and mesothelioma treatment.''; J Cancer Res Clin Oncol, 2018 PubMed Europe PMC Scholia
6. Yuan X, Dai M, Xu D; ''TERT promoter mutations and GABP transcription factors in carcinogenesis: More foes than friends.''; Cancer Lett, 2020 PubMed Europe PMC Scholia
7. Dratwa M, Wysoczańska B, Łacina P, Kubik T, Bogunia-Kubik K; ''TERT-Regulation and Roles in Cancer Formation.''; Front Immunol, 2020 PubMed Europe PMC Scholia
8. Masclef L, Ahmed O, Estavoyer B, Larrivée B, Labrecque N, Nijnik A, Affar EB; ''Roles and mechanisms of BAP1 deubiquitinase in tumor suppression.''; Cell Death Differ, 2021 PubMed Europe PMC Scholia
9. Sekido Y; ''Targeting the Hippo Pathway Is a New Potential Therapeutic Modality for Malignant Mesothelioma.''; Cancers (Basel), 2018 PubMed Europe PMC Scholia
10. Coleman SJ, Bruce C, Chioni AM, Kocher HM, Grose RP; ''The ins and outs of fibroblast growth factor receptor signalling.''; Clin Sci (Lond), 2014 PubMed Europe PMC Scholia
11. Volodko N, Gordon M, Salla M, Ghazaleh HA, Baksh S; ''RASSF tumor suppressor gene family: biological functions and regulation.''; FEBS Lett, 2014 PubMed Europe PMC Scholia
12. Napoli F, Listì A, Zambelli V, Witel G, Bironzo P, Papotti M, Volante M, Scagliotti G, Righi L; ''Pathological Characterization of Tumor Immune Microenvironment (TIME) in Malignant Pleural Mesothelioma.''; Cancers (Basel), 2021 PubMed Europe PMC Scholia
13. Liu Z, Klominek J; ''Regulation of matrix metalloprotease activity in malignant mesothelioma cell lines by growth factors.''; Thorax, 2003 PubMed Europe PMC Scholia
14. Marie-Claude Jaurand, Didier Jean; ''Biomolecular Pathways and Malignant Pleural Mesothelioma''; Malignant Pleural Mesothelioma: Present Status and Future Directions, 2015 DOI Scholia
15. Zanconato F, Cordenonsi M, Piccolo S; ''YAP/TAZ at the Roots of Cancer.''; Cancer Cell, 2016 PubMed Europe PMC Scholia
16. Kato S, Tomson BN, Buys TP, Elkin SK, Carter JL, Kurzrock R; ''Genomic Landscape of Malignant Mesotheliomas.''; Mol Cancer Ther, 2016 PubMed Europe PMC Scholia
17. Dobrokhotov O, Samsonov M, Sokabe M, Hirata H; ''Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms.''; Clin Transl Med, 2018 PubMed Europe PMC Scholia
18. Carbone M, Yang H, Pass HI, Krausz T, Testa JR, Gaudino G; ''BAP1 and cancer.''; Nat Rev Cancer, 2013 PubMed Europe PMC Scholia
19. Klominek J, Sumitran Karuppan S, Hauzenberger D; ''Differential motile response of human malignant mesothelioma cells to fibronectin, laminin and collagen type IV: the role of beta1 integrins.''; Int J Cancer, 1997 PubMed Europe PMC Scholia
20. Pirker C, Bilecz A, Grusch M, Mohr T, Heidenreich B, Laszlo V, Stockhammer P, Lötsch-Gojo D, Gojo J, Gabler L, Spiegl-Kreinecker S, Dome B, Steindl A, Klikovits T, Hoda MA, Jakopovic M, Samarzija M, Mohorcic K, Kern I, Kiesel B, Brcic L, Oberndorfer F, Müllauer L, Klepetko W, Schmidt WM, Kumar R, Hegedus B, Berger W; ''Telomerase Reverse Transcriptase Promoter Mutations Identify a Genomically Defined and Highly Aggressive Human Pleural Mesothelioma Subgroup.''; Clin Cancer Res, 2020 PubMed Europe PMC Scholia
21. Illei PB, Ladanyi M, Rusch VW, Zakowski MF; ''The use of CDKN2A deletion as a diagnostic marker for malignant mesothelioma in body cavity effusions.''; Cancer, 2003 PubMed Europe PMC Scholia
22. Yuan X, Larsson C, Xu D; ''Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players.''; Oncogene, 2019 PubMed Europe PMC Scholia
23. Hylebos M, Van Camp G, van Meerbeeck JP, Op de Beeck K; ''The Genetic Landscape of Malignant Pleural Mesothelioma: Results from Massively Parallel Sequencing.''; J Thorac Oncol, 2016 PubMed Europe PMC Scholia
24. Bononi A, Giorgi C, Patergnani S, Larson D, Verbruggen K, Tanji M, Pellegrini L, Signorato V, Olivetto F, Pastorino S, Nasu M, Napolitano A, Gaudino G, Morris P, Sakamoto G, Ferris LK, Danese A, Raimondi A, Tacchetti C, Kuchay S, Pass HI, Affar EB, Yang H, Pinton P, Carbone M; ''BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation.''; Nature, 2017 PubMed Europe PMC Scholia
25. Benedetti S, Nuvoli B, Catalani S, Galati R; ''Reactive oxygen species a double-edged sword for mesothelioma.''; Oncotarget, 2015 PubMed Europe PMC Scholia
26. Morani F, Bisceglia L, Rosini G, Mutti L, Melaiu O, Landi S, Gemignani F; ''Identification of Overexpressed Genes in Malignant Pleural Mesothelioma.''; Int J Mol Sci, 2021 PubMed Europe PMC Scholia
27. Obacz J, Yung H, Shamseddin M, Linnane E, Liu X, Azad AA, Rassl DM, Fairen-Jimenez D, Rintoul RC, Nikolić MZ, Marciniak SJ; ''Biological basis for novel mesothelioma therapies.''; Br J Cancer, 2021 PubMed Europe PMC Scholia
28. Yap TA, Aerts JG, Popat S, Fennell DA; ''Novel insights into mesothelioma biology and implications for therapy.''; Nat Rev Cancer, 2017 PubMed Europe PMC Scholia
29. Cakiroglu E, Senturk S; ''Genomics and Functional Genomics of Malignant Pleural Mesothelioma.''; Int J Mol Sci, 2020 PubMed Europe PMC Scholia
30. Tallet A, Nault JC, Renier A, Hysi I, Galateau-Sallé F, Cazes A, Copin MC, Hofman P, Andujar P, Le Pimpec-Barthes F, Zucman-Rossi J, Jaurand MC, Jean D; ''Overexpression and promoter mutation of the TERT gene in malignant pleural mesothelioma.''; Oncogene, 2014 PubMed Europe PMC Scholia
31. Eletr ZM, Wilkinson KD; ''An emerging model for BAP1's role in regulating cell cycle progression.''; Cell Biochem Biophys, 2011 PubMed Europe PMC Scholia
32. Carbone M, Adusumilli PS, Alexander HR Jr, Baas P, Bardelli F, Bononi A, Bueno R, Felley-Bosco E, Galateau-Salle F, Jablons D, Mansfield AS, Minaai M, de Perrot M, Pesavento P, Rusch V, Severson DT, Taioli E, Tsao A, Woodard G, Yang H, Zauderer MG, Pass HI; ''Mesothelioma: Scientific clues for prevention, diagnosis, and therapy.''; CA Cancer J Clin, 2019 PubMed Europe PMC Scholia
33. Chapel DB, Churg A, Santoni-Rugiu E, Tsujimura T, Hiroshima K, Husain AN; ''Molecular pathways and diagnosis in malignant mesothelioma: A review of the 14th International Conference of the International Mesothelioma Interest Group.''; Lung Cancer, 2019 PubMed Europe PMC Scholia
34. Urso L, Calabrese F, Favaretto A, Conte P, Pasello G; ''Critical review about MDM2 in cancer: Possible role in malignant mesothelioma and implications for treatment.''; Crit Rev Oncol Hematol, 2016 PubMed Europe PMC Scholia
35. Nusse R; ''Wnt signaling in disease and in development.''; Cell Res, 2005 PubMed Europe PMC Scholia
36. Crispi S, Calogero RA, Santini M, Mellone P, Vincenzi B, Citro G, Vicidomini G, Fasano S, Meccariello R, Cobellis G, Menegozzo S, Pierantoni R, Facciolo F, Baldi A, Menegozzo M; ''Global gene expression profiling of human pleural mesotheliomas: identification of matrix metalloproteinase 14 (MMP-14) as potential tumour target.''; PLoS One, 2009 PubMed Europe PMC Scholia
37. Edwards JG, McLaren J, Jones JL, Waller DA, O'Byrne KJ; ''Matrix metalloproteinases 2 and 9 (gelatinases A and B) expression in malignant mesothelioma and benign pleura.''; Br J Cancer, 2003 PubMed Europe PMC Scholia
38. Ghareghomi S, Ahmadian S, Zarghami N, Kahroba H; ''Fundamental insights into the interaction between telomerase/TERT and intracellular signaling pathways.''; Biochimie, 2021 PubMed Europe PMC Scholia
39. Whitson BA, Kratzke RA; ''Molecular pathways in malignant pleural mesothelioma.''; Cancer Lett, 2006 PubMed Europe PMC Scholia

History

External references

DataNodes

Name	Type	Database reference	Comment
14-3-3	Protein	A0A0J9YWE8 (Uniprot-TrEMBL)
26S Proteasome Degradation	Pathway	WP183 (WikiPathways)
4E-BP	GeneProduct	ENSG00000187840 (Ensembl)
ACTA1	GeneProduct	ENSG00000143632 (Ensembl)
ACTA2	GeneProduct	ENSG00000107796 (Ensembl)
ACTB	GeneProduct	ENSG00000075624 (Ensembl)
ACTC1	GeneProduct	ENSG00000159251 (Ensembl)
ACTG1	GeneProduct	ENSG00000184009 (Ensembl)
ACTG2	GeneProduct	ENSG00000163017 (Ensembl)
ADAMTS1	GeneProduct	ENSG00000154734 (Ensembl)
AJUBA	GeneProduct	ENSG00000129474 (Ensembl)
AKT1	GeneProduct	ENSG00000142208 (Ensembl)
AKT2	GeneProduct	ENSG00000105221 (Ensembl)
AKT3	GeneProduct	ENSG00000117020 (Ensembl)
AMOT	GeneProduct	ENSG00000126016 (Ensembl)
ANGPT1	GeneProduct	ENSG00000154188 (Ensembl)
ANGPT2	GeneProduct	ENSG00000091879 (Ensembl)
ANGPT4	GeneProduct	ENSG00000101280 (Ensembl)
AP2	GeneProduct	ENSG00000170323 (Ensembl)
APC	GeneProduct	ENSG00000134982 (Ensembl)
AREG	GeneProduct	ENSG00000109321 (Ensembl)
ASXL1	GeneProduct	ENSG00000171456 (Ensembl)
ATF2	GeneProduct	ENSG00000115966 (Ensembl)
ATF3	GeneProduct	ENSG00000162772 (Ensembl)
ATG13	GeneProduct	ENSG00000175224 (Ensembl)
ATM	GeneProduct	ENSG00000149311 (Ensembl)
AXIN1	GeneProduct	ENSG00000103126 (Ensembl)
Angiogenesis	Pathway	WP1993 (WikiPathways)
Apoptosis	Pathway	WP1772 (WikiPathways)
Arginine	Metabolite	CHEBI:29016 (ChEBI)
Autophagy	Pathway	WP4923 (WikiPathways)
BAG2	GeneProduct	ENSG00000112208 (Ensembl)
BAK	GeneProduct	ENSG00000030110 (Ensembl)
BAP1	GeneProduct	ENSG00000163930 (Ensembl)	The Cancer Genome Atlas Data Portal entry for BAP1: https://portal.gdc.cancer.gov/genes/ENSG00000163930 Onco KnowledgeBase entry for BAP1: https://www.oncokb.org/gene/BAP1 neXtProt entry for BAP1: https://www.nextprot.org/entry/NX_Q92560/
BARD1	GeneProduct	ENSG00000138376 (Ensembl)
BAX	GeneProduct	ENSG00000087088 (Ensembl)
BCL2	GeneProduct	ENSG00000171791 (Ensembl)
BCLXL	GeneProduct	ENSG00000171791 (Ensembl)
BDNF	GeneProduct	ENSG00000176697 (Ensembl)
BECLIN1	GeneProduct	ENSG00000126581 (Ensembl)
BMI1	GeneProduct	ENSG00000168283 (Ensembl)
BRCA1	GeneProduct	ENSG00000012048 (Ensembl)
BTC	GeneProduct	ENSG00000174808 (Ensembl)
BTRC	GeneProduct	ENSG00000166167 (Ensembl)
CASPASE-1	GeneProduct	ENSG00000137752 (Ensembl)
CCL2	GeneProduct	ENSG00000108691 (Ensembl)
CCL4	GeneProduct	ENSG00000275302 (Ensembl)
CCL5	GeneProduct	ENSG00000271503 (Ensembl)
CCND1	GeneProduct	ENSG00000110092 (Ensembl)
CCND2	GeneProduct	ENSG00000118971 (Ensembl)
CCND3	GeneProduct	ENSG00000112576 (Ensembl)
CD44	GeneProduct	ENSG00000026508 (Ensembl)
CD47	GeneProduct	ENSG00000196776 (Ensembl)
CDH10	GeneProduct	ENSG00000040731 (Ensembl)
CDH11	GeneProduct	ENSG00000140937 (Ensembl)
CDH12	GeneProduct	ENSG00000154162 (Ensembl)
CDH13	GeneProduct	ENSG00000140945 (Ensembl)
CDH15	GeneProduct	ENSG00000129910 (Ensembl)
CDH16	GeneProduct	ENSG00000166589 (Ensembl)
CDH17	GeneProduct	ENSG00000079112 (Ensembl)
CDH18	GeneProduct	ENSG00000145526 (Ensembl)
CDH19	GeneProduct	ENSG00000071991 (Ensembl)
CDH1	GeneProduct	ENSG00000039068 (Ensembl)
CDH20	GeneProduct	ENSG00000101542 (Ensembl)
CDH22	GeneProduct	ENSG00000149654 (Ensembl)
CDH24	GeneProduct	ENSG00000139880 (Ensembl)
CDH2	GeneProduct	ENSG00000170558 (Ensembl)
CDH3	GeneProduct	ENSG00000062038 (Ensembl)
CDH4	GeneProduct	ENSG00000179242 (Ensembl)
CDH5	GeneProduct	ENSG00000179776 (Ensembl)
CDH6	GeneProduct	ENSG00000113361 (Ensembl)
CDH7	GeneProduct	ENSG00000081138 (Ensembl)
CDH8	GeneProduct	ENSG00000150394 (Ensembl)
CDH9	GeneProduct	ENSG00000113100 (Ensembl)
CDK2	GeneProduct	ENSG00000123374 (Ensembl)
CDK4	GeneProduct	ENSG00000135446 (Ensembl)
CDK7	GeneProduct	ENSG00000134058 (Ensembl)
CDKN1A	GeneProduct	ENSG00000124762 (Ensembl)	P21
CDKN2A	GeneProduct	ENSG00000147889 (Ensembl)
CER1	GeneProduct	ENSG00000147869 (Ensembl)
CHD8	GeneProduct	ENSG00000100888 (Ensembl)
CIT	GeneProduct	ENSG00000122966 (Ensembl)
CNNE1	GeneProduct	ENSG00000105173 (Ensembl)
COL4A1	GeneProduct	ENSG00000187498 (Ensembl)
COL4A2	GeneProduct	ENSG00000134871 (Ensembl)
COL4A3	GeneProduct	ENSG00000169031 (Ensembl)
COL4A4	GeneProduct	ENSG00000081052 (Ensembl)
COL4A5	GeneProduct	ENSG00000188153 (Ensembl)
COL4A6	GeneProduct	ENSG00000197565 (Ensembl)
CREB1	GeneProduct	ENSG00000118260 (Ensembl)
CSF1	GeneProduct	ENSG00000184371 (Ensembl)
CSF1R	GeneProduct	ENSG00000182578 (Ensembl)
CSF2	GeneProduct	ENSG00000164400 (Ensembl)
CSF3	GeneProduct	ENSG00000108342 (Ensembl)
CSNK1A1	GeneProduct	ENSG00000113712 (Ensembl)
CSNK1A1L	GeneProduct	ENSG00000180138 (Ensembl)
CSNK1E	GeneProduct	ENSG00000213923 (Ensembl)
CSNK2A1	GeneProduct	ENSG00000101266 (Ensembl)
CSNK2A2	GeneProduct	ENSG00000070770 (Ensembl)
CSNK2A3	GeneProduct	ENSG00000254598 (Ensembl)
CSNK2B	GeneProduct	ENSG00000204435 (Ensembl)
CTBP1	GeneProduct	ENSG00000159692 (Ensembl)
CTBP2	GeneProduct	ENSG00000175029 (Ensembl)
CTGF	GeneProduct	ENSG00000118523 (Ensembl)
CTHRC1	GeneProduct	ENSG00000164932 (Ensembl)
CTNNA1	GeneProduct	ENSG00000044115 (Ensembl)
CTNNA2	GeneProduct	ENSG00000066032 (Ensembl)
CTNNA3	GeneProduct	ENSG00000183230 (Ensembl)
CTNNB1	GeneProduct	ENSG00000168036 (Ensembl)
CUL1	GeneProduct	ENSG00000055130 (Ensembl)
CXCL10	GeneProduct	ENSG00000169245 (Ensembl)
CXCL12	GeneProduct	ENSG00000107562 (Ensembl)
CXCL1	GeneProduct	ENSG00000163739 (Ensembl)
CXCL5	GeneProduct	ENSG00000163735 (Ensembl)
CXXC4	GeneProduct	ENSG00000168772 (Ensembl)
CYCS	GeneProduct	ENSG00000172115 (Ensembl)	Cytochrome C
Ca2+	Metabolite	CHEBI:29108 (ChEBI)
Cell cycle	Pathway	WP179 (WikiPathways)
Cell migration	Pathway	WP4561 (WikiPathways)
Cyclin D	GeneProduct	ENSG00000110092 (Ensembl)
DDIT3	GeneProduct	ENSG00000175197 (Ensembl)
DEPTOR	GeneProduct	ENSG00000155792 (Ensembl)
DKK1	GeneProduct	ENSG00000107984 (Ensembl)
DKK2	GeneProduct	ENSG00000155011 (Ensembl)
DKK4	GeneProduct	ENSG00000104371 (Ensembl)
DNA repair	Pathway	WP4946 (WikiPathways)
DR5	GeneProduct	ENSG00000196363 (Ensembl)
DSC3	GeneProduct	ENSG00000134762 (Ensembl)
DVL1	GeneProduct	ENSG00000107404 (Ensembl)
DVL2	GeneProduct	ENSG00000004975 (Ensembl)
DVL3	GeneProduct	ENSG00000161202 (Ensembl)
E2F1	GeneProduct	ENSG00000101412 (Ensembl)
EED	GeneProduct	ENSG00000074266 (Ensembl)
EFNA1	GeneProduct	ENSG00000169242 (Ensembl)
EFNA2	GeneProduct	ENSG00000099617 (Ensembl)
EFNA3	GeneProduct	ENSG00000143590 (Ensembl)
EFNA4	GeneProduct	ENSG00000243364 (Ensembl)
EFNA5	GeneProduct	ENSG00000184349 (Ensembl)
EGF	GeneProduct	ENSG00000138798 (Ensembl)
EGFR	GeneProduct	ENSG00000146648 (Ensembl)
EIF4B	GeneProduct	ENSG00000063046 (Ensembl)
EIF4	GeneProduct	ENSG00000114867 (Ensembl)
ELK1	GeneProduct	ENSG00000126767 (Ensembl)
EPHA2	GeneProduct	ENSG00000142627 (Ensembl)
ERK1	GeneProduct	ENSG00000102882 (Ensembl)
ERK2	GeneProduct	ENSG00000100030 (Ensembl)
ERK5	GeneProduct	ENSG00000166484 (Ensembl)
EZH2	GeneProduct	ENSG00000106462 (Ensembl)
FAK	GeneProduct	ENSG00000169398 (Ensembl)
FGF10	GeneProduct	ENSG00000070193 (Ensembl)
FGF11	GeneProduct	ENSG00000161958 (Ensembl)
FGF12	GeneProduct	ENSG00000114279 (Ensembl)
FGF13	GeneProduct	ENSG00000129682 (Ensembl)
FGF14	GeneProduct	ENSG00000102466 (Ensembl)
FGF17	GeneProduct	ENSG00000158815 (Ensembl)
FGF18	GeneProduct	ENSG00000156427 (Ensembl)
FGF19	GeneProduct	ENSG00000162344 (Ensembl)
FGF1	GeneProduct	ENSG00000113578 (Ensembl)
FGF20	GeneProduct	ENSG00000078579 (Ensembl)
FGF21	GeneProduct	ENSG00000105550 (Ensembl)
FGF22	GeneProduct	ENSG00000070388 (Ensembl)
FGF23	GeneProduct	ENSG00000118972 (Ensembl)
FGF2	GeneProduct	ENSG00000138685 (Ensembl)
FGF3	GeneProduct	ENSG00000186895 (Ensembl)
FGF4	GeneProduct	ENSG00000075388 (Ensembl)
FGF5	GeneProduct	ENSG00000138675 (Ensembl)
FGF6	GeneProduct	ENSG00000111241 (Ensembl)
FGF7	GeneProduct	ENSG00000140285 (Ensembl)
FGF8	GeneProduct	ENSG00000107831 (Ensembl)
FGF9	GeneProduct	ENSG00000102678 (Ensembl)
FGFR1	GeneProduct	ENSG00000077782 (Ensembl)
FGFR2	GeneProduct	ENSG00000066468 (Ensembl)
FGFR3	GeneProduct	ENSG00000068078 (Ensembl)
FGFR4	GeneProduct	ENSG00000160867 (Ensembl)
FIP200	GeneProduct	ENSG00000023287 (Ensembl)
FLT1	GeneProduct	ENSG00000102755 (Ensembl)
FLT3	GeneProduct	ENSG00000122025 (Ensembl)
FLT3LG	GeneProduct	ENSG00000090554 (Ensembl)
FLT4	GeneProduct	ENSG00000037280 (Ensembl)
FN1	GeneProduct	ENSG00000115414 (Ensembl)
FOSL1	GeneProduct	ENSG00000175592 (Ensembl)
FOXM1	GeneProduct	ENSG00000111206 (Ensembl)
FOXO1	GeneProduct	ENSG00000150907 (Ensembl)
FRAT1	GeneProduct	ENSG00000165879 (Ensembl)
FRAT2	GeneProduct	ENSG00000181274 (Ensembl)
FZD10	GeneProduct	ENSG00000111432 (Ensembl)
FZD1	GeneProduct	ENSG00000157240 (Ensembl)
FZD2	GeneProduct	ENSG00000180340 (Ensembl)
FZD3	GeneProduct	ENSG00000104290 (Ensembl)
FZD4	GeneProduct	ENSG00000106483 (Ensembl)
FZD5	GeneProduct	ENSG00000163251 (Ensembl)
FZD6	GeneProduct	ENSG00000164930 (Ensembl)
FZD7	GeneProduct	ENSG00000155760 (Ensembl)
FZD8	GeneProduct	ENSG00000177283 (Ensembl)
FZD9	GeneProduct	ENSG00000188763 (Ensembl)
GABPA	GeneProduct	ENSG00000154727 (Ensembl)
GDP	Metabolite	CHEBI:17552 (ChEBI)
GRB2	GeneProduct	ENSG00000177885 (Ensembl)
GSK3B	GeneProduct	ENSG00000082701 (Ensembl)
GTP	Metabolite	CHEBI:37565 (ChEBI)
Gluconeogenesis	Pathway	WP534 (WikiPathways)
HBEGF	GeneProduct	ENSG00000113070 (Ensembl)
HCFC1	GeneProduct	ENSG00000172534 (Ensembl)
HGF	GeneProduct	ENSG00000019991 (Ensembl)
HIF1A	GeneProduct	ENSG00000100644 (Ensembl)
HMGB1	GeneProduct	ENSG00000189403 (Ensembl)
HMGN1	GeneProduct	ENSG00000205581 (Ensembl)
Histone modifications	Pathway	WP2369 (WikiPathways)
IDO1	GeneProduct	ENSG00000131203 (Ensembl)
IGF1	GeneProduct	ENSG00000017427 (Ensembl)
IGF1R	GeneProduct	ENSG00000140443 (Ensembl)
IGF2	GeneProduct	ENSG00000167244 (Ensembl)
IL-1B	GeneProduct	ENSG00000125538 (Ensembl)
IL10	GeneProduct	ENSG00000136634 (Ensembl)
IL34	GeneProduct	ENSG00000157368 (Ensembl)
IL6	GeneProduct	ENSG00000136244 (Ensembl)
INS	GeneProduct	ENSG00000254647 (Ensembl)
INSR	GeneProduct	ENSG00000171105 (Ensembl)
ITGA1	GeneProduct	ENSG00000213949 (Ensembl)
ITGA2	GeneProduct	ENSG00000164171 (Ensembl)
ITGA3	GeneProduct	ENSG00000005884 (Ensembl)
ITGA4	GeneProduct	ENSG00000115232 (Ensembl)
ITGA6	GeneProduct	ENSG00000091409 (Ensembl)
ITGAV	GeneProduct	ENSG00000138448 (Ensembl)
ITGB1	GeneProduct	ENSG00000150093 (Ensembl)
ITGB2	GeneProduct	ENSG00000160255 (Ensembl)
ITGB3	GeneProduct	ENSG00000259207 (Ensembl)
ITGB4	GeneProduct	ENSG00000132470 (Ensembl)
ITPR3	GeneProduct	ENSG00000096433 (Ensembl)
JAK/STAT pathway	Pathway	WP2593 (WikiPathways)
JAK	GeneProduct	ENSG00000162434 (Ensembl)
JUN	GeneProduct	ENSG00000177606 (Ensembl)
KDM6A	GeneProduct	ENSG00000147050 (Ensembl)
KDR	GeneProduct	ENSG00000128052 (Ensembl)
KIBRA	GeneProduct	ENSG00000113645 (Ensembl)
KIF23	GeneProduct	ENSG00000137807 (Ensembl)
KIT	GeneProduct	ENSG00000157404 (Ensembl)
KITLG	GeneProduct	ENSG00000049130 (Ensembl)
KMT2C	GeneProduct	ENSG00000055609 (Ensembl)
KREMEN1	GeneProduct	ENSG00000183762 (Ensembl)
Kynurenine	Metabolite	CHEBI:28683 (ChEBI)
LAMA1	GeneProduct	ENSG00000101680 (Ensembl)
LAMA2	GeneProduct	ENSG00000196569 (Ensembl)
LAMA3	GeneProduct	ENSG00000053747 (Ensembl)
LAMA4	GeneProduct	ENSG00000112769 (Ensembl)
LAMA5	GeneProduct	ENSG00000130702 (Ensembl)
LAMB1	GeneProduct	ENSG00000091136 (Ensembl)
LAMB2	GeneProduct	ENSG00000172037 (Ensembl)
LAMB3	GeneProduct	ENSG00000196878 (Ensembl)
LAMC1	GeneProduct	ENSG00000135862 (Ensembl)
LAMC2	GeneProduct	ENSG00000058085 (Ensembl)
LAMC3	GeneProduct	ENSG00000050555 (Ensembl)
LATS1	GeneProduct	ENSG00000131023 (Ensembl)
LATS2	GeneProduct	ENSG00000150457 (Ensembl)
LEF1	GeneProduct	ENSG00000138795 (Ensembl)
LGALS9	GeneProduct	ENSG00000168961 (Ensembl)
LIMD1	GeneProduct	ENSG00000144791 (Ensembl)
LIN28B	GeneProduct	ENSG00000187772 (Ensembl)
LRP5	GeneProduct	ENSG00000162337 (Ensembl)
LRP6	GeneProduct	ENSG00000070018 (Ensembl)
MAD1	GeneProduct	ENSG00000002822 (Ensembl)
MAD2L1	GeneProduct	ENSG00000164109 (Ensembl)
MAP2K1	GeneProduct	ENSG00000169032 (Ensembl)
MAP2K2	GeneProduct	ENSG00000126934 (Ensembl)
MAP2K3	GeneProduct	ENSG00000034152 (Ensembl)
MAP2K4	GeneProduct	ENSG00000065559 (Ensembl)
MAP2K6	GeneProduct	ENSG00000108984 (Ensembl)
MAP2K7	GeneProduct	ENSG00000076984 (Ensembl)
MAP3K10	GeneProduct	ENSG00000130758 (Ensembl)
MAP3K11	GeneProduct	ENSG00000173327 (Ensembl)
MAP3K1	GeneProduct	ENSG00000095015 (Ensembl)
MAP3K2	GeneProduct	ENSG00000169967 (Ensembl)
MAP3K3	GeneProduct	ENSG00000198909 (Ensembl)
MAP3K4	GeneProduct	ENSG00000085511 (Ensembl)
MAP3K5	GeneProduct	ENSG00000197442 (Ensembl)
MAP3K6	GeneProduct	ENSG00000142733 (Ensembl)
MAP3K9	GeneProduct	ENSG00000006432 (Ensembl)
MAP4K1	GeneProduct	ENSG00000104814 (Ensembl)
MAP4K2	GeneProduct	ENSG00000168067 (Ensembl)
MAP4K3	GeneProduct	ENSG00000011566 (Ensembl)
MAP4K4	GeneProduct	ENSG00000071054 (Ensembl)
MAPK signaling pathway	Pathway	WP382 (WikiPathways)
MAPK10	GeneProduct	ENSG00000109339 (Ensembl)
MAPK14	GeneProduct	ENSG00000112062 (Ensembl)
MAPK8	GeneProduct	ENSG00000107643 (Ensembl)
MAPK9	GeneProduct	ENSG00000050748 (Ensembl)
MAPKAPK2	GeneProduct	ENSG00000162889 (Ensembl)
MAX	GeneProduct	ENSG00000125952 (Ensembl)
MCL1	GeneProduct	ENSG00000143384 (Ensembl)
MCU	GeneProduct	ENSG00000156026 (Ensembl)
MDK	GeneProduct	ENSG00000110492 (Ensembl)
MDM2	GeneProduct	ENSG00000135679 (Ensembl)
MDM4	GeneProduct	ENSG00000198625 (Ensembl)
MEF2D	GeneProduct	ENSG00000116604 (Ensembl)
MEK5	GeneProduct	ENSG00000137764 (Ensembl)
MET	GeneProduct	ENSG00000105976 (Ensembl)
MINK1	GeneProduct	ENSG00000141503 (Ensembl)
MKNK1	GeneProduct	ENSG00000079277 (Ensembl)
MKNK2	GeneProduct	ENSG00000099875 (Ensembl)
MLST8	GeneProduct	ENSG00000167965 (Ensembl)
MMP14	GeneProduct	ENSG00000157227 (Ensembl)
MMP2	GeneProduct	ENSG00000087245 (Ensembl)
MMP3	GeneProduct	ENSG00000149968 (Ensembl)
MMP9	GeneProduct	ENSG00000100985 (Ensembl)
MOB1A	GeneProduct	ENSG00000114978 (Ensembl)
MOB1B	GeneProduct	ENSG00000173542 (Ensembl)
MST1	GeneProduct	ENSG00000173531 (Ensembl)
MTOR	GeneProduct	ENSG00000198793 (Ensembl)
MYC	GeneProduct	ENSG00000136997 (Ensembl)
NDRG1	GeneProduct	ENSG00000104419 (Ensembl)	NDR1/2
NF-KB	GeneProduct	ENSG00000109320 (Ensembl)
NF2	GeneProduct	ENSG00000186575 (Ensembl)
NGF	GeneProduct	ENSG00000134259 (Ensembl)
NGFR	GeneProduct	ENSG00000064300 (Ensembl)
NLRP3	GeneProduct	ENSG00000162711 (Ensembl)
NOTUM	GeneProduct	ENSG00000185269 (Ensembl)
NTF3	GeneProduct	ENSG00000185652 (Ensembl)
NTF4	GeneProduct	ENSG00000225950 (Ensembl)
NTRK1	GeneProduct	ENSG00000198400 (Ensembl)
NTRK2	GeneProduct	ENSG00000148053 (Ensembl)	Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
OGT	GeneProduct	ENSG00000147162 (Ensembl)
P21	GeneProduct	ENSG00000124762 (Ensembl)
PAK1	GeneProduct	ENSG00000149269 (Ensembl)
PAK2	GeneProduct	ENSG00000180370 (Ensembl)
PAK3	GeneProduct	ENSG00000077264 (Ensembl)
PAK4	GeneProduct	ENSG00000130669 (Ensembl)
PAK5	GeneProduct	ENSG00000101349 (Ensembl)
PAK6	GeneProduct	ENSG00000137843 (Ensembl)
PD-L1	GeneProduct	ENSG00000120217 (Ensembl)
PDGFA	GeneProduct	ENSG00000197461 (Ensembl)
PDGFB	GeneProduct	ENSG00000100311 (Ensembl)
PDGFC	GeneProduct	ENSG00000145431 (Ensembl)
PDGFD	GeneProduct	ENSG00000170962 (Ensembl)
PDGF	GeneProduct	ENSG00000197461 (Ensembl)
PDGFRA	GeneProduct	ENSG00000134853 (Ensembl)
PDGFRB	GeneProduct	ENSG00000113721 (Ensembl)
PDK1	GeneProduct	ENSG00000152256 (Ensembl)
PGF	GeneProduct	ENSG00000119630 (Ensembl)
PHC1	GeneProduct	ENSG00000111752 (Ensembl)
PI3K-Akt signaling pathway	Pathway	WP4172 (WikiPathways)
PIGF	GeneProduct	ENSG00000151665 (Ensembl)
PIK3CA	GeneProduct	ENSG00000121879 (Ensembl)
PIK3CB	GeneProduct	ENSG00000051382 (Ensembl)
PIK3CD	GeneProduct	ENSG00000171608 (Ensembl)
PIK3CG	GeneProduct	ENSG00000105851 (Ensembl)
PIP2	Metabolite	CHEBI:18348 (ChEBI)
PIP3	Metabolite	CHEBI:16618 (ChEBI)
PLAU	GeneProduct	ENSG00000122861 (Ensembl)
PLCB4	GeneProduct	ENSG00000101333 (Ensembl)
PODXL	GeneProduct	ENSG00000128567 (Ensembl)
PORCN	GeneProduct	ENSG00000102312 (Ensembl)
PPARGC1A	GeneProduct	ENSG00000109819 (Ensembl)
PRAS40	GeneProduct	ENSG00000204673 (Ensembl)
PRB1	GeneProduct	ENSG00000251655 (Ensembl)
PRKAA1	GeneProduct	ENSG00000132356 (Ensembl)
PRKAA2	GeneProduct	ENSG00000162409 (Ensembl)
PRKAB1	GeneProduct	ENSG00000111725 (Ensembl)
PRKAB2	GeneProduct	ENSG00000131791 (Ensembl)
PRKAG1	GeneProduct	ENSG00000181929 (Ensembl)
PRKAG2	GeneProduct	ENSG00000106617 (Ensembl)
PRKAG3	GeneProduct	ENSG00000115592 (Ensembl)
PRSS23	GeneProduct	ENSG00000150687 (Ensembl)
PTEN	GeneProduct	ENSG00000171862 (Ensembl)
PUMA	GeneProduct	ENSG00000105327 (Ensembl)
Pro IL-1B	GeneProduct	ENSG00000125538 (Ensembl)
RAF	GeneProduct	ENSG00000132155 (Ensembl)
RAGE	GeneProduct	ENSG00000204305 (Ensembl)
RAS	GeneProduct	ENSG00000174775 (Ensembl)
RASSF1	GeneProduct	ENSG00000068028 (Ensembl)
RASSF2	GeneProduct	ENSG00000101265 (Ensembl)
RASSF3	GeneProduct	ENSG00000153179 (Ensembl)
RASSF4	GeneProduct	ENSG00000107551 (Ensembl)
RASSF5	GeneProduct	ENSG00000266094 (Ensembl)
RASSF6	GeneProduct	ENSG00000169435 (Ensembl)
RASSF7	GeneProduct	ENSG00000099849 (Ensembl)
RBBP4	GeneProduct	ENSG00000162521 (Ensembl)
RHEB	GeneProduct	ENSG00000106615 (Ensembl)
RING1	GeneProduct	ENSG00000204227 (Ensembl)
RNF2	GeneProduct	ENSG00000121481 (Ensembl)
RNS	Metabolite	Q225595 (Wikidata)
ROR1	GeneProduct	ENSG00000185483 (Ensembl)
ROR2	GeneProduct	ENSG00000169071 (Ensembl)
ROS	Metabolite	CHEBI:70982 (ChEBI)
RPS6	GeneProduct	ENSG00000137154 (Ensembl)
RPS6KA1	GeneProduct	ENSG00000117676 (Ensembl)
RPS6KA3	GeneProduct	ENSG00000177189 (Ensembl)
RPS6KA5	GeneProduct	ENSG00000100784 (Ensembl)
RPS6KB1	GeneProduct	ENSG00000108443 (Ensembl)
RPS6KB2	GeneProduct	ENSG00000175634 (Ensembl)
RPTOR	GeneProduct	ENSG00000141564 (Ensembl)
RYK	GeneProduct	ENSG00000163785 (Ensembl)
SAV1	GeneProduct	ENSG00000151748 (Ensembl)
SELE	GeneProduct	ENSG00000007908 (Ensembl)
SENP2	GeneProduct	ENSG00000163904 (Ensembl)
SERPINF1	GeneProduct	ENSG00000132386 (Ensembl)
SETD2	GeneProduct	ENSG00000181555 (Ensembl)
SETD5	GeneProduct	ENSG00000168137 (Ensembl)
SETDB1	GeneProduct	ENSG00000143379 (Ensembl)
SFRP1	GeneProduct	ENSG00000104332 (Ensembl)
SFRP2	GeneProduct	ENSG00000145423 (Ensembl)
SFRP4	GeneProduct	ENSG00000106483 (Ensembl)
SFRP5	GeneProduct	ENSG00000120057 (Ensembl)
SHC	GeneProduct	ENSG00000160691 (Ensembl)
SLC2A1	GeneProduct	ENSG00000117394 (Ensembl)
SLC3A2	GeneProduct	ENSG00000168003 (Ensembl)
SLC7A5	GeneProduct	ENSG00000103257 (Ensembl)
SOS	GeneProduct	ENSG00000115904 (Ensembl)
SOST	GeneProduct	ENSG00000167941 (Ensembl)
SOX17	GeneProduct	ENSG00000164736 (Ensembl)
SP1	GeneProduct	ENSG00000185591 (Ensembl)
SPARC	GeneProduct	ENSG00000113140 (Ensembl)
SRC	GeneProduct	ENSG00000197122 (Ensembl)
STAT1	GeneProduct	ENSG00000115415 (Ensembl)
STAT	GeneProduct	ENSG00000115415 (Ensembl)
STK38L	GeneProduct	ENSG00000211455 (Ensembl)	NDR1/2
STK3	GeneProduct	ENSG00000104375 (Ensembl)
SUZ12	GeneProduct	ENSG00000178691 (Ensembl)
TCA cycle	Pathway	WP78 (WikiPathways)	Also known as Krebs or citric acid cycle
TCF7	GeneProduct	ENSG00000081059 (Ensembl)
TCF7L1	GeneProduct	ENSG00000152284 (Ensembl)
TCF7L2	GeneProduct	ENSG00000148737 (Ensembl)
TEAD1	GeneProduct	ENSG00000187079 (Ensembl)
TEAD2	GeneProduct	ENSG00000074219 (Ensembl)
TEAD3	GeneProduct	ENSG00000007866 (Ensembl)
TEAD4	GeneProduct	ENSG00000197905 (Ensembl)
TEK	GeneProduct	ENSG00000120156 (Ensembl)
TEL2	GeneProduct	ENSG00000100726 (Ensembl)
TERT	GeneProduct	ENSG00000164362 (Ensembl)
TGFA	GeneProduct	ENSG00000163235 (Ensembl)
TGFB1	GeneProduct	ENSG00000105329 (Ensembl)
TNIK	GeneProduct	ENSG00000154310 (Ensembl)
TNNT1	GeneProduct	ENSG00000105048 (Ensembl)
TP53	GeneProduct	ENSG00000141510 (Ensembl)
TRAF2	GeneProduct	ENSG00000127191 (Ensembl)
TSC1	GeneProduct	ENSG00000165699 (Ensembl)
TSC2	GeneProduct	ENSG00000103197 (Ensembl)
TTI1	GeneProduct	ENSG00000101407 (Ensembl)
Tryptophan	Metabolite	CHEBI:16828 (ChEBI)
UHRF1	GeneProduct	ENSG00000276043 (Ensembl)
ULK1	GeneProduct	ENSG00000177169 (Ensembl)
ULK2	GeneProduct	ENSG00000083290 (Ensembl)
Unfolded protein response	Pathway	WP4925 (WikiPathways)
VEGFA	GeneProduct	ENSG00000112715 (Ensembl)
VEGFB	GeneProduct	ENSG00000173511 (Ensembl)
VEGFC	GeneProduct	ENSG00000150630 (Ensembl)
VEGFD	GeneProduct	ENSG00000165197 (Ensembl)
VEGF	GeneProduct	ENSG00000112715 (Ensembl)
VGLL4	GeneProduct	ENSG00000144560 (Ensembl)
WIF1	GeneProduct	ENSG00000156076 (Ensembl)
WNT10A	GeneProduct	ENSG00000135925 (Ensembl)
WNT10B	GeneProduct	ENSG00000169884 (Ensembl)
WNT11	GeneProduct	ENSG00000085741 (Ensembl)
WNT16	GeneProduct	ENSG00000002745 (Ensembl)
WNT1	GeneProduct	ENSG00000125084 (Ensembl)
WNT2B	GeneProduct	ENSG00000134245 (Ensembl)
WNT2	GeneProduct	ENSG00000105989 (Ensembl)
WNT3A	GeneProduct	ENSG00000154342 (Ensembl)
WNT3	GeneProduct	ENSG00000108379 (Ensembl)
WNT4	GeneProduct	ENSG00000162552 (Ensembl)
WNT5A	GeneProduct	ENSG00000114251 (Ensembl)
WNT5B	GeneProduct	ENSG00000111186 (Ensembl)
WNT6	GeneProduct	ENSG00000115596 (Ensembl)
WNT7A	GeneProduct	ENSG00000154764 (Ensembl)
WNT7B	GeneProduct	ENSG00000188064 (Ensembl)
WWTR1	GeneProduct	ENSG00000018408 (Ensembl)
Wnt signaling	Pathway	WP428 (WikiPathways)
YAP	GeneProduct	ENSG00000137693 (Ensembl)
YY1	GeneProduct	ENSG00000100811 (Ensembl)
c-fos	Metabolite	CHEBI:62519 (ChEBI)
c-jun	GeneProduct	ENSG00000177606 (Ensembl)
fra-1	GeneProduct	ENSG00000175592 (Ensembl)
glucose	Metabolite	CHEBI:17234 (ChEBI)
let-7	Rna	ENSG00000284520 (Ensembl)
p14ARF	Protein	Q8N726 (Uniprot-TrEMBL)
p16INK4A	GeneProduct	P42771 (Uniprot-TrEMBL)
prostaglandin E2	Metabolite	CHEBI:15551 (ChEBI)