Kinin-Kallikrein pathway (Homo sapiens)

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1, 2Blood vesselSERPING1F12KLKB1BradykininCPN1Des-arg(9)-bradykininBDKRB1BDKRB2KNG1


Description

Kinin-Kallikrein pathway that leads to bradykinin receptor 1 (BDKRB1) and receptor 2 (BDKRB2) activation in Homo sapiens starting from FXII.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bryant JW, Shariat-Madar Z; ''Human plasma kallikrein-kinin system: physiological and biochemical parameters.''; Cardiovasc Hematol Agents Med Chem, 2009 PubMed Europe PMC Scholia
  2. Garvin MR, Alvarez C, Miller JI, Prates ET, Walker AM, Amos BK, Mast AE, Justice A, Aronow B, Jacobson D; ''A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm.''; Elife, 2020 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129066view02:53, 10 March 2024EweitzUse gene symbols, standardize case
129063view02:14, 10 March 2024EweitzModified description
129062view02:13, 10 March 2024EweitzEconomize layout
118192view11:43, 25 May 2021AriajadhavUpdated pathway data nodes
117971view11:02, 23 May 2021EweitzModified title
116322view11:37, 30 April 2021Marvin M2Ontology Term : 'kallikrein-kinin cascade pathway' added !
116313view15:13, 29 April 2021AriajadhavNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BDKRB1ProteinG3V4Y2 (Uniprot-TrEMBL)
BDKRB2Protein624 (Entrez Gene)
BradykininProtein9606 (NCBI Protein)
CPN1GeneProductENSG00000120054 (Ensembl)
Des-arg(9)-bradykininMetabolite133068 (ChEBI)
F12GeneProductENSG00000131187 (Ensembl)
KLKB1GeneProductENSG00000164344 (Ensembl)
KNG1GeneProductENSG00000113889 (Ensembl)
SERPING1GeneProductENSG00000149131 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP5089"
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